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Study · Measured the body's own peptide · 2025

2 results

Epimedin C promotes mitochondrial transfer and delays thymus atrophy in 4-VCD induced mimetic-menopausal mice.

Ying Y, Hu S, Shu Y, He B, Cheng G, Wang H, Tao N, Hoffman R, Shi D, Chen Z, Chen X, Gao J

Phytomedicine : international journal of phytotherapy and phytopharmacology3 Feb 2025Cited by 6 (Europe PMC)

PMID39919331 (opens in a new tab)DOI10.1016/j.phymed.2025.156452 (opens in a new tab)PepBankPUB-39919331
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In mimetic-menopausal mice, Epimedin C treatment was linked to lower Tβ4 expression in the thymus.

    In plain wordsIn mice with menopause-like changes, Epimedin C lowered the body's own thymosin beta‑4 in the thymus.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseThymic Tβ4 expression after Epimedin C
    Study

    mousen: not reported in source

    4-VCD induced mimetic-menopausal mice
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    which related with the downregulation of Tβ4 and obstruction to the formation of Tβ4-G-actin complex.
    1 context sentence
    Summary · context
    Epimedin C can promote TEC activity in 4-VCD induced mimetic-menopausal mice by decreasing the expression of Tβ4, inhibiting the binding of Tβ4 to G-actin, promoting the F-actin polymerization and the TNTs-depended MitoT.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone1

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 02AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Mechanism

    In mimetic-menopausal mice, Epimedin C obstructed the formation of the Tβ4-G-actin complex.

    In plain wordsIn mice with menopause-like changes, Epimedin C blocked the body's own thymosin beta‑4 from binding G-actin.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseTβ4-G-actin complex formation
    Study

    mousen: not reported in source

    4-VCD induced mimetic-menopausal mice
    Outcome group
    Receptor activity and mechanism · Immune and inflammation

    Source sentences

    Summary
    obstruction to the formation of Tβ4-G-actin complex.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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