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Study · Animal study (in vivo) · 2025

4 results

Glepaglutide-Loaded Foam for the Induction of Mucosal Healing in the Treatment of Inflammatory Bowel Disease.

Zhang W, Van den Bossche W, Yagoubi H, Kambale EK, Wahni K, Saxena T, Guilbaud L, Moreels TG, Messens J, Beloqui A

Advanced healthcare materials5 Feb 2025Cited by 2 (Europe PMC)

PMID39905897 (opens in a new tab)PMCIDPMC11912111 (opens in a new tab)DOI10.1002/adhm.202403497 (opens in a new tab)PepBankPUB-39905897
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In a DSS-induced colitis model, glepaglutide-loaded foam significantly reduced colitis severity.

    In plain wordsIn animals with DSS-induced colitis, glepaglutide-loaded foam significantly reduced disease severity.

    Peptide
    Glepaglutide
    Outcome
    DecreaseColitis severity
    Study

    n: not reported in source

    Dextran sodium sulfate-induced colitis
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated · rectal foamAs given in this study.

    Source sentences

    Summary
    In a dextran sodium sulfate (DSS)-induced colitis model, the GL-loaded foam (GLF) significantly mitigated the severity of colitis.
    1 context sentence
    Summary · context
    To address this challenge, GL was loaded into a rectal foam formulation using CO2 as a permeation enhancer to combine both the local and systemic effects of the GLP-2 analog.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In a DSS-induced colitis model, glepaglutide-loaded foam facilitated mucosal healing, as shown by colonoscopy images.

    In plain wordsIn animals with DSS-induced colitis, colonoscopy images showed that glepaglutide-loaded foam helped the intestinal lining heal.

    Peptide
    Glepaglutide
    Outcome
    IncreaseMucosal healing on colonoscopy
    Study

    n: not reported in source

    Dextran sodium sulfate-induced colitis
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated · rectal foamAs given in this study.

    Source sentences

    Summary
    GLF facilitated mucosal healing, as evidenced by colonoscopy images, increased plasma markers of mucosal healing, and increased crypt depth.
    2 context sentences
    Summary · context
    In a dextran sodium sulfate (DSS)-induced colitis model, the GL-loaded foam (GLF) significantly mitigated the severity of colitis.
    Summary · context
    To address this challenge, GL was loaded into a rectal foam formulation using CO2 as a permeation enhancer to combine both the local and systemic effects of the GLP-2 analog.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In a DSS-induced colitis model, glepaglutide-loaded foam increased plasma markers of mucosal healing.

    In plain wordsIn animals with DSS-induced colitis, glepaglutide-loaded foam increased blood markers of intestinal lining healing.

    Peptide
    Glepaglutide
    Outcome
    IncreasePlasma markers of mucosal healing
    Study

    n: not reported in source

    Dextran sodium sulfate-induced colitis
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated · rectal foamAs given in this study.

    Source sentences

    Summary
    GLF facilitated mucosal healing, as evidenced by colonoscopy images, increased plasma markers of mucosal healing, and increased crypt depth.
    2 context sentences
    Summary · context
    In a dextran sodium sulfate (DSS)-induced colitis model, the GL-loaded foam (GLF) significantly mitigated the severity of colitis.
    Summary · context
    To address this challenge, GL was loaded into a rectal foam formulation using CO2 as a permeation enhancer to combine both the local and systemic effects of the GLP-2 analog.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In a DSS-induced colitis model, glepaglutide-loaded foam increased crypt depth.

    In plain wordsIn animals with DSS-induced colitis, glepaglutide-loaded foam increased intestinal crypt depth.

    Peptide
    Glepaglutide
    Outcome
    IncreaseCrypt depth
    Study

    n: not reported in source

    Dextran sodium sulfate-induced colitis
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated · rectal foamAs given in this study.

    Source sentences

    Summary
    GLF facilitated mucosal healing, as evidenced by colonoscopy images, increased plasma markers of mucosal healing, and increased crypt depth.
    2 context sentences
    Summary · context
    In a dextran sodium sulfate (DSS)-induced colitis model, the GL-loaded foam (GLF) significantly mitigated the severity of colitis.
    Summary · context
    To address this challenge, GL was loaded into a rectal foam formulation using CO2 as a permeation enhancer to combine both the local and systemic effects of the GLP-2 analog.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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