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Study · Randomized controlled trial · n = 13 · 2025

2 results

Effect of a GnRH injection on kisspeptin levels in girls with suspected precocious puberty: a randomized-controlled pilot study.

Rodanaki M, Rask E, Lodefalk M

Journal of pediatric endocrinology & metabolism : JPEM24 Jan 2025

PMID39847034 (opens in a new tab)DOI10.1515/jpem-2024-0606 (opens in a new tab)PepBankPUB-39847034
Publisher pagePubMedAsk about this study
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Summary

ObjectivesKisspeptin plays a major role in the onset of puberty by stimulating the gonadotropin-releasing hormone (GnRH) neurons. The aim of this study was to investigate whether GnRH inhibits kisspeptin secretion via a negative feedback mechanism and potential associations between kisspeptin levels and other hormones of importance for pubertal onset.MethodsThirteen girls with suspected central precocious puberty underwent a GnRH stimulation test twice in a randomized, placebo-controlled manner. Blood was sampled up to 150 min after an IV injection of either Relefact LHRH® or saline. The levels of kisspeptin, acylated ghrelin, ultrasensitive oestradiol, luteinizing hormone (LH), follicle-stimulating hormone (FSH), insulin and glucose were analysed.ResultsBaseline kisspeptin levels ranged from 9.9 to 201.6 pg/mL. Neither area under the curve for kisspeptin levels nor peaks were significantly lower after the GnRH injection compared to placebo. Baseline kisspeptin and glucose levels tended to be associated (rho=0.55, p=0.051) but no other associations were found between kisspeptin and other hormones.ConclusionsBasal levels of kisspeptin vary widely in young girls. We found no evidence of a negative feedback mechanism of GnRH on kisspeptin in this small pilot study. The suggested association between kisspeptin and glucose levels needs further investigations.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In girls with suspected central precocious puberty, the area under the curve for kisspeptin was not significantly lower after GnRH injection than after placebo.

    In plain wordsIn girls with suspected early puberty, a GnRH injection did not lower kisspeptin levels compared with placebo.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    No significant changeKisspeptin area under the curve after GnRH injection
    Study

    n = 13

    Comparator
    Saline placebo
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Source sentences

    Summary
    Neither area under the curve for kisspeptin levels nor peaks were significantly lower after the GnRH injection compared to placebo.
    2 context sentences
    Summary · context
    Thirteen girls with suspected central precocious puberty underwent a GnRH stimulation test twice in a randomized, placebo-controlled manner.
    Summary · context
    Blood was sampled up to 150 min after an IV injection of either Relefact LHRH® or saline.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In girls with suspected central precocious puberty, kisspeptin peaks were not significantly lower after GnRH injection than after placebo.

    In plain wordsIn girls with suspected early puberty, kisspeptin peaks were not lower after a GnRH injection than after placebo.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    No significant changeKisspeptin peak after GnRH injection
    Study

    n = 13

    Comparator
    Saline placebo
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Source sentences

    Summary
    Neither area under the curve for kisspeptin levels nor peaks were significantly lower after the GnRH injection compared to placebo.
    2 context sentences
    Summary · context
    Thirteen girls with suspected central precocious puberty underwent a GnRH stimulation test twice in a randomized, placebo-controlled manner.
    Summary · context
    Blood was sampled up to 150 min after an IV injection of either Relefact LHRH® or saline.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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