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Study · Measured the body's own peptide · 2025

2 results

Plasma Humanin and Non-Coding RNAs as Biomarkers of Endothelial Dysfunction in Rheumatoid Arthritis: A Pilot Study.

Coradduzza D, Cruciani S, Di Lorenzo B, De Miglio MR, Zinellu A, Maioli M, Medici S, Erre GL, Carru C

Non-coding RNA14 Jan 2025Cited by 2 (Europe PMC)

PMID39846683 (opens in a new tab)PMCIDPMC11755443 (opens in a new tab)DOI10.3390/ncrna11010005 (opens in a new tab)PepBankPUB-39846683
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Summary

Background: Rheumatoid arthritis (RA) is a chronic autoimmune disorder associated with an increased risk of cardiovascular disease (CVD), largely driven by peripheral endothelial dysfunction (ED). Humanin, a mitochondrial-derived peptide, has been suggested to play a protective role in endothelial function. However, the relationship between Humanin levels and ED in RA, as well as the interaction between Humanin and non-coding RNAs such as Long Non-Coding RNA GAS5, microRNA-21 (miR-21), and microRNA-103 (miR-103), remains unclear. Objective: This study aimed to investigate the relationship between circulating Humanin levels, non-coding RNAs (GAS5, miR-21, miR-103), and endothelial dysfunction (ED) in patients with RA. Additionally, we explored the correlation between Humanin expression and specific non-coding RNAs (GAS5, miR-21, and miR-103) to better understand their potential role in vascular health. Methods: Peripheral ED was assessed using flow-mediated pulse amplitude tonometry, with Ln-RHI values Results: Higher Humanin levels were significantly associated with better endothelial function (OR = 0.9774, p = 0.0196). Kaplan-Meier analysis demonstrated that higher Humanin levels correlated with improved survival (p < 0.0001). The non-coding RNAs (GAS5, miR-21, and miR-103) did not show significant associations with ED. Conclusions: Humanin is a potential protective biomarker for endothelial dysfunction and survival in RA patients. Further research is needed to explore the interaction between Humanin and non-coding RNAs in the context of vascular health.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In patients with rheumatoid arthritis, higher circulating Humanin levels were associated with lower odds of endothelial dysfunction.

    In plain wordsIn people with rheumatoid arthritis, higher levels of the body's own Humanin were linked to better blood vessel function.

    Peptide
    Humanin
    Outcome
    DecreaseEndothelial dysfunction, association with plasma Humanin
    Study

    n: not reported in source

    Outcome group
    Lung injury and fibrosis · Cardiovascular

    Measurements

    OR
    0.9774 ratio
    endothelial dysfunction

    Source sentences

    Summary
    Higher Humanin levels were significantly associated with better endothelial function (OR = 0.9774, p = 0.0196).
    1 context sentence
    Summary · context
    This study aimed to investigate the relationship between circulating Humanin levels, non-coding RNAs (GAS5, miR-21, miR-103), and endothelial dysfunction (ED) in patients with RA.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In patients with rheumatoid arthritis, higher circulating Humanin levels correlated with improved survival in Kaplan-Meier analysis.

    In plain wordsIn people with rheumatoid arthritis, higher levels of the body's own Humanin were linked to better survival.

    Peptide
    Humanin
    Outcome
    IncreaseSurvival, association with plasma Humanin
    Study

    n: not reported in source

    Outcome group
    Mortality · Whole body

    Source sentences

    Summary
    Kaplan-Meier analysis demonstrated that higher Humanin levels correlated with improved survival (p < 0.0001).
    1 context sentence
    Summary · context
    This study aimed to investigate the relationship between circulating Humanin levels, non-coding RNAs (GAS5, miR-21, miR-103), and endothelial dysfunction (ED) in patients with RA.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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