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Study · Measured the body's own peptide · 2025

5 results

Hepatic and Pancreatic Cellular Response to Early Life Nutritional Mismatch.

Ghosh S, Ganguly A, Habib M, Shin BC, Thamotharan S, Andersson S, Devaskar SU

Endocrinology1 Feb 2025Cited by 2 (Europe PMC)

PMID39823439 (opens in a new tab)PMCIDPMC11815087 (opens in a new tab)DOI10.1210/endocr/bqaf007 (opens in a new tab)PepBankPUB-39823439
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyMechanism

    In human amniotic fluid from type 1 diabetes mellitus pregnancies, humanin was increased.

    In plain wordsAmniotic fluid from type 1 diabetes pregnancies had higher natural humanin levels.

    Peptide
    Humanin
    Outcome
    IncreaseHumanin in amniotic fluid of type 1 diabetes pregnancies
    Study

    n: not reported in source

    Outcome group
    Glycemic control · Endocrine and hormones

    Source sentences

    Summary
    type 1 diabetes mellitus human amniotic fluid increased humanin.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In male rats with intrauterine growth restriction and postnatal high fat with fructose diet, beta-islet humanin was reduced.

    In plain wordsIn male rats with growth restriction before birth and a high-fat, high-fructose diet, natural humanin in pancreatic islets was lower.

    Peptide
    Humanin
    Outcome
    DecreaseBeta-islet humanin in IUGR-HFhf males
    Study

    ratn: not reported in source

    Prenatal caloric restriction (IUGR) followed by high fat with fructose diet
    Outcome group
    Glycemic control · Endocrine and hormones

    Source sentences

    Summary
    IUGR-HFhf males demonstrated reduced β-islet insulin and humanin, and type 1 diabetes mellitus human amniotic fluid increased humanin.
    1 context sentence
    Summary · context
    In prenatal caloric-restricted rats with intrauterine growth restriction (IUGR) and postnatal exposure to high fat with fructose (HFhf) or high carbohydrate, we investigated male and female IUGR-HFhf and IUGR-high carbohydrate, vs HFhf and control offspring.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone3

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 03LabNot a test of Humanin aloneOther designMechanism

    In beta-islets, humanin suppression disabled glucose stimulated insulin secretion.

    In plain wordsIn lab tests on pancreatic islets, reducing humanin disabled insulin release in response to glucose.

    Peptide
    Humanin
    Outcome
    DecreaseGlucose stimulated insulin secretion with humanin suppression
    Study

    n: not reported in source

    Pancreatic beta-islets with humanin suppression
    Outcome group
    Glycemic control · Endocrine and hormones

    Source sentences

    Summary
    Humanin suppression disabled glucose stimulated insulin, ATP production, with apoptotic diminished β-islet viability.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 04LabNot a test of Humanin aloneOther designMechanism

    In beta-islets, humanin suppression disabled ATP production.

    In plain wordsIn lab tests on pancreatic islets, reducing humanin disabled energy (ATP) production.

    Peptide
    Humanin
    Outcome
    DecreaseATP production with humanin suppression
    Study

    n: not reported in source

    Pancreatic beta-islets with humanin suppression
    Outcome group
    Mitochondrial function · Endocrine and hormones

    Source sentences

    Summary
    Humanin suppression disabled glucose stimulated insulin, ATP production, with apoptotic diminished β-islet viability.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 05LabNot a test of Humanin aloneOther designMechanism

    In beta-islets, humanin suppression diminished viability, with apoptosis.

    In plain wordsIn lab tests on pancreatic islets, reducing humanin lowered islet cell survival.

    Peptide
    Humanin
    Outcome
    DecreaseBeta-islet viability with humanin suppression
    Study

    n: not reported in source

    Pancreatic beta-islets with humanin suppression
    Outcome group
    Glycemic control · Endocrine and hormones

    Source sentences

    Summary
    Humanin suppression disabled glucose stimulated insulin, ATP production, with apoptotic diminished β-islet viability.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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