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Study · Animal study (in vivo) · mouse · 2025

9 results

Humanin alone and in combination with GnRHa therapy attenuates ovarian dysfunction induced by prepubertal cyclophosphamide chemotherapy in female mice.

Liu L, Wang H, Wen W, Wang S, Zuo L, Cheng Y, Rao M, Ma Y, Tang L

Reproductive toxicology (Elmsford, N.Y.)8 Jan 2025

PMID39793741 (opens in a new tab)DOI10.1016/j.reprotox.2024.108824 (opens in a new tab)PepBankPUB-39793741
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In female mice with cyclophosphamide-induced ovarian damage, HNG alone significantly mitigated the reduction in follicles.

    In plain wordsIn female mice with chemotherapy-induced ovary damage, humanin alone limited the loss of follicles.

    Peptide
    Humanin
    Outcome
    IncreaseFollicle number
    Study

    mousen: not reported in source

    Prepubertal cyclophosphamide-induced ovarian damage in female mice
    Comparator
    CP model
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Notably, HNG treatment, both alone and in conjunction with GnRHa, significantly mitigated these adverse effects, however the combination did not provide additional benefits over HNG alone regarding follicles preservation and antioxidant capacity.
    2 context sentences
    Summary · context
    evidenced by reduced follicles
    Summary · context
    The 21-day-old C57BL/6 J female mice were randomly assigned to six groups: Control, CP model, HNG, HNG+CP, GnRHa+CP, and HNG+GnRHa+CP.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In female mice with cyclophosphamide-induced ovarian damage, HNG alone significantly mitigated the hormonal imbalances.

    In plain wordsIn female mice with chemotherapy-induced ovary damage, humanin alone limited the changes in sex hormone levels.

    Peptide
    Humanin
    Outcome
    MixedSerum sex hormone levels
    Study

    mousen: not reported in source

    Prepubertal cyclophosphamide-induced ovarian damage in female mice
    Comparator
    CP model
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Notably, HNG treatment, both alone and in conjunction with GnRHa, significantly mitigated these adverse effects, however the combination did not provide additional benefits over HNG alone regarding follicles preservation and antioxidant capacity.
    2 context sentences
    Summary · context
    hormonal imbalances
    Summary · context
    The 21-day-old C57BL/6 J female mice were randomly assigned to six groups: Control, CP model, HNG, HNG+CP, GnRHa+CP, and HNG+GnRHa+CP.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In female mice with cyclophosphamide-induced ovarian damage, HNG alone significantly mitigated the prolonged estrous cycles.

    In plain wordsIn female mice with chemotherapy-induced ovary damage, humanin alone limited the lengthening of the reproductive cycle.

    Peptide
    Humanin
    Outcome
    DecreaseEstrous cycle length
    Study

    mousen: not reported in source

    Prepubertal cyclophosphamide-induced ovarian damage in female mice
    Comparator
    CP model
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Notably, HNG treatment, both alone and in conjunction with GnRHa, significantly mitigated these adverse effects, however the combination did not provide additional benefits over HNG alone regarding follicles preservation and antioxidant capacity.
    2 context sentences
    Summary · context
    prolonged estrous cycles
    Summary · context
    The 21-day-old C57BL/6 J female mice were randomly assigned to six groups: Control, CP model, HNG, HNG+CP, GnRHa+CP, and HNG+GnRHa+CP.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In female mice with cyclophosphamide-induced ovarian damage, HNG alone significantly mitigated the reduction in body weight.

    In plain wordsIn female mice with chemotherapy-induced ovary damage, humanin alone limited the loss of body weight.

    Peptide
    Humanin
    Outcome
    IncreaseBody weight
    Study

    mousen: not reported in source

    Prepubertal cyclophosphamide-induced ovarian damage in female mice
    Comparator
    CP model
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Notably, HNG treatment, both alone and in conjunction with GnRHa, significantly mitigated these adverse effects, however the combination did not provide additional benefits over HNG alone regarding follicles preservation and antioxidant capacity.
    2 context sentences
    Summary · context
    reduced body weight
    Summary · context
    The 21-day-old C57BL/6 J female mice were randomly assigned to six groups: Control, CP model, HNG, HNG+CP, GnRHa+CP, and HNG+GnRHa+CP.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In female mice with cyclophosphamide-induced ovarian damage, HNG alone significantly mitigated the reduction in ovarian and uterine weights.

    In plain wordsIn female mice with chemotherapy-induced ovary damage, humanin alone limited the shrinking of ovary and womb weight.

    Peptide
    Humanin
    Outcome
    IncreaseOvarian and uterine weights
    Study

    mousen: not reported in source

    Prepubertal cyclophosphamide-induced ovarian damage in female mice
    Comparator
    CP model
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Notably, HNG treatment, both alone and in conjunction with GnRHa, significantly mitigated these adverse effects, however the combination did not provide additional benefits over HNG alone regarding follicles preservation and antioxidant capacity.
    2 context sentences
    Summary · context
    diminished ovarian and uterine weights
    Summary · context
    The 21-day-old C57BL/6 J female mice were randomly assigned to six groups: Control, CP model, HNG, HNG+CP, GnRHa+CP, and HNG+GnRHa+CP.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In female mice with cyclophosphamide-induced ovarian damage, HNG treatment was followed by significant enrichment of inflammation and immune response pathways in the transcriptome.

    In plain wordsIn female mice with chemotherapy-induced ovary damage, humanin treatment changed gene activity in inflammation and immune pathways.

    Peptide
    Humanin
    Outcome
    Not applicableOvarian transcriptome pathways after HNG
    Study

    mousen: not reported in source

    Prepubertal cyclophosphamide-induced ovarian damage in female mice
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Transcriptomic analysis revealed significant enrichment in inflammation and immune response pathways following HNG treatment.
    1 context sentence
    Summary · context
    The 21-day-old C57BL/6 J female mice were randomly assigned to six groups: Control, CP model, HNG, HNG+CP, GnRHa+CP, and HNG+GnRHa+CP.

Studies that did not test the peptide alone3

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 07AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In female mice with cyclophosphamide-induced ovarian damage, HNG combined with GnRHa significantly mitigated the adverse effects of cyclophosphamide.

    In plain wordsIn female mice with chemotherapy-induced ovary damage, humanin plus a GnRH agonist limited the harm from chemotherapy.

    Peptide
    Humanin
    Outcome
    DecreaseAdverse effects of cyclophosphamide with HNG plus GnRHa
    Study

    mousen: not reported in source

    Prepubertal cyclophosphamide-induced ovarian damage in female mice
    Comparator
    CP model
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Notably, HNG treatment, both alone and in conjunction with GnRHa, significantly mitigated these adverse effects, however the combination did not provide additional benefits over HNG alone regarding follicles preservation and antioxidant capacity.
    1 context sentence
    Summary · context
    The 21-day-old C57BL/6 J female mice were randomly assigned to six groups: Control, CP model, HNG, HNG+CP, GnRHa+CP, and HNG+GnRHa+CP.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 08AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In female mice with cyclophosphamide-induced ovarian damage, HNG plus GnRHa did not preserve follicles better than HNG alone.

    In plain wordsIn female mice with chemotherapy-induced ovary damage, adding a GnRH agonist to humanin did not protect follicles more than humanin alone.

    Peptide
    Humanin
    Outcome
    No significant changeFollicle preservation, HNG plus GnRHa versus HNG alone
    Study

    mousen: not reported in source

    Prepubertal cyclophosphamide-induced ovarian damage in female mice
    Comparator
    HNG alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    however the combination did not provide additional benefits over HNG alone regarding follicles preservation and antioxidant capacity.
    1 context sentence
    Summary · context
    The 21-day-old C57BL/6 J female mice were randomly assigned to six groups: Control, CP model, HNG, HNG+CP, GnRHa+CP, and HNG+GnRHa+CP.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 09AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In female mice with cyclophosphamide-induced ovarian damage, HNG plus GnRHa did not improve antioxidant capacity more than HNG alone.

    In plain wordsIn female mice with chemotherapy-induced ovary damage, adding a GnRH agonist to humanin did not raise antioxidant capacity more than humanin alone.

    Peptide
    Humanin
    Outcome
    No significant changeAntioxidant capacity, HNG plus GnRHa versus HNG alone
    Study

    mousen: not reported in source

    Prepubertal cyclophosphamide-induced ovarian damage in female mice
    Comparator
    HNG alone
    Outcome group
    Inflammation markers · Reproductive and sexual health

    Source sentences

    Summary
    however the combination did not provide additional benefits over HNG alone regarding follicles preservation and antioxidant capacity.
    1 context sentence
    Summary · context
    The 21-day-old C57BL/6 J female mice were randomly assigned to six groups: Control, CP model, HNG, HNG+CP, GnRHa+CP, and HNG+GnRHa+CP.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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