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Study · Animal study (in vivo) · mouse · 2025

3 results

Administration of nicotinamide mononucleotide suppresses the progression of age-related hearing loss in mice.

Hattori K, Hamaguchi T, Azuma-Suzuki R, Higashi S, Manji A, Morifuji M

Hearing research5 Jan 2025Cited by 2 (Europe PMC)

PMID39778468 (opens in a new tab)DOI10.1016/j.heares.2025.109182 (opens in a new tab)PepBankPUB-39778468
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In C57BL/6J mice, oral NMN suppressed development of age-related hearing loss.

    In plain wordsIn mice, oral NMN reduced the development of age-related hearing loss.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseAge-related hearing loss
    Study

    mousen: not reported in source

    C57BL/6J age-related hearing loss
    Outcome group
    Sensory perception · Nervous system and cognition
    Studied dose
    500 mg/kg/day · oralAs given in this study (mouse).

    Source sentences

    Summary
    Oral administration of NMN at 500 mg/kg/day effectively suppressed the development of ARHL in C57BL/6J mice.
    1 context sentence
    Summary · context
    To clarify the effect of NAD+ supplementation on ARHL, C57BL/6J mice used as an animal model of ARHL were treated with nicotinamide mononucleotide (NMN), a precursor of NAD+.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice, NMN increased inner ear NAD+ levels.

    In plain wordsIn mice, NMN increased NAD+ levels in the inner ear.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseInner ear NAD+
    Study

    mousen: not reported in source

    C57BL/6J age-related hearing loss
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    500 mg/kg/day · oralAs given in this study (mouse).

    Source sentences

    Summary
    NMN administration resulted in increased NAD+ levels in inner ear tissues and induced changes in the transcriptome, specifically in genes related to metal ion metabolism.
    1 context sentence
    Summary · context
    To clarify the effect of NAD+ supplementation on ARHL, C57BL/6J mice used as an animal model of ARHL were treated with nicotinamide mononucleotide (NMN), a precursor of NAD+.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice, NMN changed inner ear expression of genes related to metal ion metabolism.

    In plain wordsIn mice, NMN changed inner ear gene expression related to metal ion metabolism.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    MixedMetal ion metabolism gene expression
    Study

    mousen: not reported in source

    C57BL/6J age-related hearing loss
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    500 mg/kg/day · oralAs given in this study (mouse).

    Source sentences

    Summary
    NMN administration resulted in increased NAD+ levels in inner ear tissues and induced changes in the transcriptome, specifically in genes related to metal ion metabolism.
    1 context sentence
    Summary · context
    To clarify the effect of NAD+ supplementation on ARHL, C57BL/6J mice used as an animal model of ARHL were treated with nicotinamide mononucleotide (NMN), a precursor of NAD+.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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