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Study · Animal study (in vivo) · mouse · 2024

7 results

Nicotinamide Mononucleotide Alleviates Bile Acid Metabolism and Hormonal Dysregulation in Letrozole-Induced PCOS Mice.

Ren C, Zhang S, Ma J, Huang J, Huang P, Qu M, Zhao H, Zhou Z, Gong A

Biology8 Dec 2024Cited by 10 (Europe PMC)

PMID39765695 (opens in a new tab)PMCIDPMC11673032 (opens in a new tab)DOI10.3390/biology13121028 (opens in a new tab)PepBankPUB-39765695
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Summary

Polycystic ovary syndrome (PCOS) involves complex genetic, metabolic, endocrine, and environmental factors. This study explores the effects of nicotinamide mononucleotide (NMN) in a letrozole-induced PCOS mouse model, focusing on metabolic regulation. Letrozole-induced aromatase inhibition elevated androgen and reduced bile acid levels, linking liver dysfunction and gut imbalance to PCOS. Letrozole-treated mice exhibited disrupted estrous cycles, ovarian congestion, and elevated testosterone. NMN intervention alleviated hyperandrogenism, ovarian abnormalities, and bile acid decline but did not fully restore the estrous cycle or improve lipid profiles. Metabolomic analysis showed that NMN partially reversed bile acid and lipid metabolism disturbances. These findings highlight NMN's protective role in reducing hyperandrogenism and ovarian cyst formation. However, effective PCOS treatment should target liver and gut metabolism, not just ovarian symptoms, to mitigate systemic effects. Bile acid dysregulation may play a key role in PCOS progression and warrants further investigation.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In PCOS mice, NMN alleviated hyperandrogenism.

    In plain wordsIn mice with PCOS, NMN reduced excessive androgen levels compared with PCOS without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseHyperandrogenism
    Study

    mousen: not reported in source

    Letrozole-induced PCOS
    Comparator
    Letrozole-induced PCOS without NMN
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN intervention alleviated hyperandrogenism, ovarian abnormalities, and bile acid decline but did not fully restore the estrous cycle or improve lipid profiles.
    1 context sentence
    Summary · context
    This study explores the effects of nicotinamide mononucleotide (NMN) in a letrozole-induced PCOS mouse model, focusing on metabolic regulation.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In PCOS mice, NMN alleviated ovarian abnormalities.

    In plain wordsIn mice with PCOS, NMN reduced ovarian abnormalities compared with PCOS without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseOvarian abnormalities
    Study

    mousen: not reported in source

    Letrozole-induced PCOS
    Comparator
    Letrozole-induced PCOS without NMN
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN intervention alleviated hyperandrogenism, ovarian abnormalities, and bile acid decline but did not fully restore the estrous cycle or improve lipid profiles.
    1 context sentence
    Summary · context
    This study explores the effects of nicotinamide mononucleotide (NMN) in a letrozole-induced PCOS mouse model, focusing on metabolic regulation.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In PCOS mice, NMN alleviated the decline in bile acid levels.

    In plain wordsIn mice with PCOS, NMN reduced the decline in bile acid levels compared with PCOS without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseBile acid levels
    Study

    mousen: not reported in source

    Letrozole-induced PCOS
    Comparator
    Letrozole-induced PCOS without NMN
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN intervention alleviated hyperandrogenism, ovarian abnormalities, and bile acid decline but did not fully restore the estrous cycle or improve lipid profiles.
    1 context sentence
    Summary · context
    This study explores the effects of nicotinamide mononucleotide (NMN) in a letrozole-induced PCOS mouse model, focusing on metabolic regulation.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In PCOS mice, NMN did not fully restore the estrous cycle.

    In plain wordsIn mice with PCOS, NMN did not fully restore reproductive cycles compared with PCOS without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Direction not reportedEstrous cycle restoration
    Study

    mousen: not reported in source

    Letrozole-induced PCOS
    Comparator
    Letrozole-induced PCOS without NMN
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN intervention alleviated hyperandrogenism, ovarian abnormalities, and bile acid decline but did not fully restore the estrous cycle or improve lipid profiles.
    1 context sentence
    Summary · context
    This study explores the effects of nicotinamide mononucleotide (NMN) in a letrozole-induced PCOS mouse model, focusing on metabolic regulation.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In PCOS mice, NMN did not improve lipid profiles.

    In plain wordsIn mice with PCOS, NMN did not improve lipid profiles compared with PCOS without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    No significant changeLipid profiles
    Study

    mousen: not reported in source

    Letrozole-induced PCOS
    Comparator
    Letrozole-induced PCOS without NMN
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN intervention alleviated hyperandrogenism, ovarian abnormalities, and bile acid decline but did not fully restore the estrous cycle or improve lipid profiles.
    1 context sentence
    Summary · context
    This study explores the effects of nicotinamide mononucleotide (NMN) in a letrozole-induced PCOS mouse model, focusing on metabolic regulation.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In PCOS mice, NMN partially reversed bile acid metabolism disturbances.

    In plain wordsIn mice with PCOS, NMN partly reversed bile acid metabolism disturbances compared with PCOS without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseBile acid metabolism disturbances
    Study

    mousen: not reported in source

    Letrozole-induced PCOS
    Comparator
    Letrozole-induced PCOS without NMN
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Metabolomic analysis showed that NMN partially reversed bile acid and lipid metabolism disturbances.
    1 context sentence
    Summary · context
    This study explores the effects of nicotinamide mononucleotide (NMN) in a letrozole-induced PCOS mouse model, focusing on metabolic regulation.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In PCOS mice, NMN partially reversed lipid metabolism disturbances.

    In plain wordsIn mice with PCOS, NMN partly reversed lipid metabolism disturbances compared with PCOS without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseLipid metabolism disturbances
    Study

    mousen: not reported in source

    Letrozole-induced PCOS
    Comparator
    Letrozole-induced PCOS without NMN
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Metabolomic analysis showed that NMN partially reversed bile acid and lipid metabolism disturbances.
    1 context sentence
    Summary · context
    This study explores the effects of nicotinamide mononucleotide (NMN) in a letrozole-induced PCOS mouse model, focusing on metabolic regulation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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