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Study · Other design · 2025

7 results

Enhancing fat graft survival: thymosin beta-4 facilitates mitochondrial transfer from ADSCs via tunneling nanotubes by upregulating the Rac/F-actin pathway.

Zhang X, Lin Y, Li H, Wang Q, Mu D

Free radical biology & medicine4 Jan 2025Cited by 7 (Europe PMC)

PMID39761767 (opens in a new tab)DOI10.1016/j.freeradbiomed.2024.12.061 (opens in a new tab)PepBankPUB-39761767
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalOther designMechanism

    In an adipose graft model, Tβ4 upregulated the Rac/F-actin pathway in adipose-derived stem cells.

    In plain wordsIn a fat graft model, thymosin beta‑4 increased activity of the Rac/F-actin pathway in fat stem cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseRac/F-actin pathway activity
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We demonstrate that Tβ4 upregulates the Rac/F-actin pathway, leading to an increased formation of TNTs and subsequent transfer of mitochondria from ADSCs.
  2. 02AnimalOther designMechanism

    In an adipose graft model, Tβ4 increased the formation of tunneling nanotubes.

    In plain wordsIn a fat graft model, thymosin beta‑4 increased formation of tunneling nanotubes between cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseTunneling nanotube formation
    Study

    n: not reported in source

    Outcome group
    Mitochondrial function · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We demonstrate that Tβ4 upregulates the Rac/F-actin pathway, leading to an increased formation of TNTs and subsequent transfer of mitochondria from ADSCs.
  3. 03AnimalOther designMechanism

    In an adipose graft model, Tβ4 increased the transfer of mitochondria from adipose-derived stem cells.

    In plain wordsIn a fat graft model, thymosin beta‑4 increased transfer of mitochondria out of fat stem cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseMitochondrial transfer from ADSCs
    Study

    n: not reported in source

    Outcome group
    Mitochondrial function · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We demonstrate that Tβ4 upregulates the Rac/F-actin pathway, leading to an increased formation of TNTs and subsequent transfer of mitochondria from ADSCs.
  4. 04AnimalOther designEfficacy outcome

    In an adipose graft model, the Tβ4-driven mitochondrial transfer mitigated oxidative stress.

    In plain wordsIn a fat graft model, the thymosin beta‑4 process reduced oxidative stress.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseOxidative stress in fat grafts
    Study

    n: not reported in source

    Outcome group
    Aging markers · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This process mitigates oxidative stress, reduces apoptosis, and promotes revascularization, thereby improving the quality and volume retention of fat grafts.
  5. 05AnimalOther designEfficacy outcome

    In an adipose graft model, the Tβ4-driven mitochondrial transfer reduced apoptosis.

    In plain wordsIn a fat graft model, the thymosin beta‑4 process reduced cell death.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseApoptosis in fat grafts
    Study

    n: not reported in source

    Outcome group
    Aging markers · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This process mitigates oxidative stress, reduces apoptosis, and promotes revascularization, thereby improving the quality and volume retention of fat grafts.
  6. 06AnimalOther designEfficacy outcome

    In an adipose graft model, the Tβ4-driven mitochondrial transfer promoted revascularization.

    In plain wordsIn a fat graft model, the thymosin beta‑4 process promoted new blood vessel growth in the graft.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseRevascularization of fat grafts
    Study

    n: not reported in source

    Outcome group
    Wound healing · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This process mitigates oxidative stress, reduces apoptosis, and promotes revascularization, thereby improving the quality and volume retention of fat grafts.
  7. 07AnimalOther designEfficacy outcome

    In an adipose graft model, the Tβ4-driven mitochondrial transfer improved the quality and volume retention of fat grafts.

    In plain wordsIn a fat graft model, the thymosin beta‑4 process improved graft quality and volume retention.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseFat graft quality and volume retention
    Study

    n: not reported in source

    Outcome group
    Wound healing · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This process mitigates oxidative stress, reduces apoptosis, and promotes revascularization, thereby improving the quality and volume retention of fat grafts.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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