[Gly14]-Humanin ameliorates high glucose-induced endothelial senescence via SIRT6.

Li M, Liu Z, Cao X, Xiao W, Wang S, Zhao C, Zhao Y, Xie Y

Scientific reports28 Dec 2024Cited by 1 (Europe PMC)

PMID39730568PMCIDPMC11681169DOI10.1038/s41598-024-81878-xPepBankPUB-39730568

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In HUVECs exposed to high glucose, pretreatment with [Gly14]-Humanin antagonized the downregulation of SIRT6.
In plain wordsIn cells, [Gly14]-Humanin kept SIRT6 from falling under high glucose.
Peptide
Humanin
Outcome
IncreaseSIRT6 downregulation by high glucose
Study
humann: not reported in source
HUVECs exposed to high glucose
Comparator
High glucose without HNG
Outcome group
Aging markers · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
pretreatment with [Gly14]-Humanin (HNG) antagonized the downregulation of SIRT6 in response to HG
1 context sentence(design, population, supporting numbers)
Summary · context
Human umbilical vein endothelial cells (HUVECs) were exposed to glucose to induce senescence, determined by β-galactosidase staining and the expressions of p21, p53, and p16.
Report a problemFND-3973056801
02LabIn vitro (cells)Mechanism
In HUVECs exposed to high glucose, pretreatment with [Gly14]-Humanin alleviated ROS production.
In plain wordsIn cells, [Gly14]-Humanin reduced production of reactive oxygen species under high glucose.
Peptide
Humanin
Outcome
DecreaseROS production
Study
humann: not reported in source
HUVECs exposed to high glucose
Comparator
High glucose without HNG
Outcome group
Aging markers · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
pretreatment with [Gly14]-Humanin (HNG) antagonized the downregulation of SIRT6 in response to HG and alleviated ROS production
1 context sentence(design, population, supporting numbers)
Summary · context
Human umbilical vein endothelial cells (HUVECs) were exposed to glucose to induce senescence, determined by β-galactosidase staining and the expressions of p21, p53, and p16.
Report a problemFND-3973056802
03LabIn vitro (cells)Mechanism
In HUVECs exposed to high glucose, pretreatment with [Gly14]-Humanin alleviated cell senescence.
In plain wordsIn cells, [Gly14]-Humanin reduced the signs of aging in blood vessel cells exposed to high glucose.
Peptide
Humanin
Outcome
DecreaseHigh glucose-induced endothelial senescence
Study
humann: not reported in source
HUVECs exposed to high glucose
Comparator
High glucose without HNG
Outcome group
Aging markers · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
pretreatment with [Gly14]-Humanin (HNG) antagonized the downregulation of SIRT6 in response to HG and alleviated ROS production and cell senescence
1 context sentence(design, population, supporting numbers)
Summary · context
Human umbilical vein endothelial cells (HUVECs) were exposed to glucose to induce senescence, determined by β-galactosidase staining and the expressions of p21, p53, and p16.
Report a problemFND-3973056803

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

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