The Mitochondria-Targeted Micelle Inhibits Alzheimer's Disease Progression by Alleviating Neuronal Mitochondrial Dysfunction and Neuroinflammation.

Qian W, Liu D, Liu J, Liu M, Ji Q, Zhang B, Yang Z, Cheng Y, Zhou S

Small (Weinheim an der Bergstrasse, Germany)23 Dec 2024Cited by 24 (Europe PMC)

PMID39713820DOI10.1002/smll.202408581PepBankPUB-39713820

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Elamipretide (SS-31).

01AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Mechanism
In 5 × FAD mice, the CsA-TK-SS‑31 micelle (cyclosporin A linked to SS‑31) restored mitochondrial membrane potential and the fission-fusion balance.
In plain wordsIn mice with Alzheimer's-like disease, a micelle combining two compounds, including SS‑31, restored mitochondrial function in brain cells.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseMitochondrial membrane potential and fission-fusion balance
Study
mousen: not reported in source
5 × FAD mice
Outcome group
Mitochondrial function · Nervous system and cognition
Source sentences
Summary
The released CsA and SS-31 synergistically restore the mitochondrial membrane potential and the balance between the fission and fusion of mitochondria, which subsequently protect neurons from apoptosis and reduce the activation of microglia in the brains of 5 × FAD mice.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein, this work designs a mitochondria-targeted micelle CsA-TK-SS-31 (CTS) to block the progression of AD by simultaneously alleviating mitochondrial dysfunction in microglia and neurons.
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-3971382001
02AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Efficacy outcome
In 5 × FAD mice, the CsA-TK-SS‑31 micelle protected neurons from apoptosis.
In plain wordsIn mice with Alzheimer's-like disease, a micelle combining two compounds, including SS‑31, protected nerve cells from death.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseNeuronal apoptosis
Study
mousen: not reported in source
5 × FAD mice
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
The released CsA and SS-31 synergistically restore the mitochondrial membrane potential and the balance between the fission and fusion of mitochondria, which subsequently protect neurons from apoptosis and reduce the activation of microglia in the brains of 5 × FAD mice.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein, this work designs a mitochondria-targeted micelle CsA-TK-SS-31 (CTS) to block the progression of AD by simultaneously alleviating mitochondrial dysfunction in microglia and neurons.
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-3971382002
03AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Efficacy outcome
In 5 × FAD mice, the CsA-TK-SS‑31 micelle reduced microglial activation.
In plain wordsIn mice with Alzheimer's-like disease, a micelle combining two compounds, including SS‑31, reduced activation of brain immune cells.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseMicroglial activation
Study
mousen: not reported in source
5 × FAD mice
Outcome group
Inflammation markers · Nervous system and cognition
Source sentences
Summary
The released CsA and SS-31 synergistically restore the mitochondrial membrane potential and the balance between the fission and fusion of mitochondria, which subsequently protect neurons from apoptosis and reduce the activation of microglia in the brains of 5 × FAD mice.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein, this work designs a mitochondria-targeted micelle CsA-TK-SS-31 (CTS) to block the progression of AD by simultaneously alleviating mitochondrial dysfunction in microglia and neurons.
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-3971382003
04AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Efficacy outcome
In 5 × FAD mice, the CsA-TK-SS‑31 micelle ameliorated neuroinflammation.
In plain wordsIn mice with Alzheimer's-like disease, a micelle combining two compounds, including SS‑31, reduced brain inflammation.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseNeuroinflammation
Study
mousen: not reported in source
5 × FAD mice
Outcome group
Inflammation markers · Nervous system and cognition
Source sentences
Summary
Ultimately, the neuroinflammation and cognitive impairment of 5 × FAD mice are ameliorated.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein, this work designs a mitochondria-targeted micelle CsA-TK-SS-31 (CTS) to block the progression of AD by simultaneously alleviating mitochondrial dysfunction in microglia and neurons.
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-3971382004
05AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Efficacy outcome
In 5 × FAD mice, the CsA-TK-SS‑31 micelle ameliorated cognitive impairment.
In plain wordsIn mice with Alzheimer's-like disease, a micelle combining two compounds, including SS‑31, improved thinking and memory problems.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseCognitive impairment
Study
mousen: not reported in source
5 × FAD mice
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
Ultimately, the neuroinflammation and cognitive impairment of 5 × FAD mice are ameliorated.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein, this work designs a mitochondria-targeted micelle CsA-TK-SS-31 (CTS) to block the progression of AD by simultaneously alleviating mitochondrial dysfunction in microglia and neurons.
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-3971382005

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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