Reprogramming of Treg cell-derived small extracellular vesicles effectively prevents intestinal inflammation from PANoptosis by blocking mitochondrial oxidative stress.

Gong W, Liu Z, Wang Y, Huang W, Yang K, Gao Z, Guo K, Xiao Z, Zhao W

Trends in biotechnology16 Dec 2024Cited by 22 (Europe PMC)

PMID39689981DOI10.1016/j.tibtech.2024.11.017PepBankPUB-39689981

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Elamipretide (SS-31).

01AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Efficacy outcome
A selenium-loaded, SS‑31-decorated Treg exosome delivery system protected against intestinal inflammation.
In plain wordsAn engineered exosome carrying selenium and SS‑31 protected against gut inflammation. The abstract does not name the model.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseIntestinal inflammation
Study
n: not reported in source
Outcome group
Inflammation markers · Gastrointestinal
Source sentences
Summary
This actively targetable exosome-derived delivery system is protected from intestinal inflammation by scavenging excessive mtROS and preventing immunologically programmed cell death pyroptosis, necroptosis, and apoptosis, known as PANoptosis.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we reprogrammed regulatory T cell (Treg)-derived exosomes loaded with the antioxidant trace element selenium (Se) and decorated them with the synthetic mitochondria-targeting SS-31 tetrapeptide via a peptide linker.
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-3968998101
02AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Mechanism
A selenium-loaded, SS‑31-decorated Treg exosome delivery system scavenged excessive mitochondrial ROS.
In plain wordsAn engineered exosome carrying selenium and SS‑31 removed excess harmful mitochondrial oxygen molecules.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseMitochondrial ROS
Study
n: not reported in source
Outcome group
Oxidative stress · Gastrointestinal
Source sentences
Summary
scavenging excessive mtROS and preventing immunologically programmed cell death pyroptosis, necroptosis, and apoptosis, known as PANoptosis.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we reprogrammed regulatory T cell (Treg)-derived exosomes loaded with the antioxidant trace element selenium (Se) and decorated them with the synthetic mitochondria-targeting SS-31 tetrapeptide via a peptide linker.
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-3968998102
03AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Mechanism
A selenium-loaded, SS‑31-decorated Treg exosome delivery system prevented PANoptosis (pyroptosis, necroptosis and apoptosis).
In plain wordsAn engineered exosome carrying selenium and SS‑31 prevented a form of programmed cell death.
Peptide
Elamipretide (SS-31)
Outcome
DecreasePANoptosis (pyroptosis, necroptosis, apoptosis)
Study
n: not reported in source
Outcome group
Inflammation markers · Gastrointestinal
Source sentences
Summary
preventing immunologically programmed cell death pyroptosis, necroptosis, and apoptosis, known as PANoptosis.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we reprogrammed regulatory T cell (Treg)-derived exosomes loaded with the antioxidant trace element selenium (Se) and decorated them with the synthetic mitochondria-targeting SS-31 tetrapeptide via a peptide linker.
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-3968998103

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.