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Study · Animal study (in vivo) · wistar rat · 2025

4 results

Kisspeptin participates in the positive reward state induced by paced mating and modulates sexual receptivity and paced mating behavior in female rats.

Bedos M, Ponce E, Corona R, Paredes RG

Hormones and behavior4 Dec 2024Cited by 1 (Europe PMC)

PMID39637765 (opens in a new tab)DOI10.1016/j.yhbeh.2024.105671 (opens in a new tab)PepBankPUB-39637765
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized female rats, Kp-10 induced receptivity at levels similar to estradiol benzoate plus progesterone.

    In plain wordsIn female rats, Kp-10 produced about the same sexual receptivity as the hormone treatment estradiol plus progesterone.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeSexual receptivity
    Study

    Wistar ratn = 9

    ovariectomized estradiol benzoate-primed female rats, paced mating
    Comparator
    Estradiol benzoate plus progesterone
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    14 nmolAs given in this study (Wistar rat).

    Source sentences

    Summary
    We demonstrated that Kp-10 (14 nmol) induced similar levels of receptivity to treatment with EB + progesterone and facilitated PM by reducing the return latency after intromissions.
    2 context sentences
    Summary · context
    In experiment 1 (n = 9), we tested the effect of Kp on PM.
    Summary · context
    In all experiments, we used sexually naïve ovariectomized Wistar female rats primed with estradiol benzoate (EB, 2.5 μg/rat) 48 h before behavioral tests.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized female rats, Kp-10 facilitated paced mating by reducing the return latency after intromissions.

    In plain wordsIn female rats, Kp-10 made females return to the male sooner after mating contact.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseReturn latency after intromissions during paced mating
    Study

    Wistar ratn = 9

    ovariectomized estradiol benzoate-primed female rats, paced mating
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    14 nmolAs given in this study (Wistar rat).

    Source sentences

    Summary
    and facilitated PM by reducing the return latency after intromissions.
    2 context sentences
    Summary · context
    In experiment 1 (n = 9), we tested the effect of Kp on PM.
    Summary · context
    In all experiments, we used sexually naïve ovariectomized Wistar female rats primed with estradiol benzoate (EB, 2.5 μg/rat) 48 h before behavioral tests.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized female rats, Kp-10 at 7 and 14 nmol induced a clear conditioned place preference, a measure of a positive reward state.

    In plain wordsIn female rats, Kp-10 caused a clear preference for the place where it was given, a sign of a rewarding effect.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseConditioned place preference
    Study

    Wistar ratn: not reported in source

    ovariectomized estradiol benzoate-primed female rats, paced mating
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    7 and 14 nmolAs given in this study (Wistar rat).

    Source sentences

    Summary
    Kp-10 (7 and 14 nmol) induced a clear conditioned place preference.
    1 context sentence
    Summary · context
    In all experiments, we used sexually naïve ovariectomized Wistar female rats primed with estradiol benzoate (EB, 2.5 μg/rat) 48 h before behavioral tests.

Studies that did not test the peptide alone1

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 04AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Mechanism

    In female rats, the Kiss1r antagonist p234 (15 nmol) blocked the reward state produced by Kp-10 and by paced mating; the result describes the antagonist.

    In plain wordsIn female rats, a drug that blocks the kisspeptin receptor removed the rewarding effect of kisspeptin and of paced mating.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseBlockade of Kp-10 reward state by the antagonist p234
    Study

    Wistar ratn: not reported in source

    ovariectomized estradiol benzoate-primed female rats, paced mating
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health

    Source sentences

    Summary
    This reward state and that produced by PM were blocked by p234 (15 nmol).
    1 context sentence
    Summary · context
    In all experiments, we used sexually naïve ovariectomized Wistar female rats primed with estradiol benzoate (EB, 2.5 μg/rat) 48 h before behavioral tests.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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