Nicotinamide mononucleotide suppresses cellular senescence and increases aquaporin 5 expression in the submandibular gland of aged male mice to ameliorate aging-related dry mouth.

Wakabayashi J, Hamaguchi T, Morifuji M, Nagata M

Biogerontology4 Dec 2024Cited by 1 (Europe PMC)

PMID39633075DOI10.1007/s10522-024-10162-2PepBankPUB-39633075

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In old male mice, NMN increased saliva secretion compared with saline.
In plain wordsIn old male mice, NMN increased saliva production compared with saline.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseSaliva secretion
Study
mousen: not reported in source
Old male mice
Comparator
Saline-treated old mice
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
300 mg/kg once every two days · subcutaneous · four weeksAs given in this study (mouse).
Source sentences
Summary
The submandibular glands from old mice treated with NMN exhibited increased saliva secretion and NAD⁺ levels, which both decrease with aging.
1 context sentence(design, population, supporting numbers)
Summary · context
Young (16-week-old) and old (113-week-old) male mice were treated subcutaneously with saline or NMN (300 mg/kg) once every two days for four weeks and saliva secretion was measured.
Report a problemFND-3963307501
02AnimalAnimal study (in vivo)Mechanism
In old male mice, NMN increased submandibular gland NAD levels compared with saline.
In plain wordsIn old male mice, NMN increased NAD levels in salivary glands compared with saline.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseSalivary gland NAD levels
Study
mousen: not reported in source
Old male mice
Comparator
Saline-treated old mice
Outcome group
Receptor activity and mechanism · Gastrointestinal
Studied dose
300 mg/kg once every two days · subcutaneous · four weeksAs given in this study (mouse).
Source sentences
Summary
The submandibular glands from old mice treated with NMN exhibited increased saliva secretion and NAD⁺ levels, which both decrease with aging.
1 context sentence(design, population, supporting numbers)
Summary · context
Young (16-week-old) and old (113-week-old) male mice were treated subcutaneously with saline or NMN (300 mg/kg) once every two days for four weeks and saliva secretion was measured.
Report a problemFND-3963307502
03AnimalAnimal study (in vivo)Mechanism
In old male mice, NMN decreased submandibular gland acetylation compared with saline.
In plain wordsIn old male mice, NMN reduced salivary gland cell acetylation compared with saline.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseCell acetylation
Study
mousen: not reported in source
Old male mice
Comparator
Saline-treated old mice
Outcome group
Aging markers · Gastrointestinal
Studied dose
300 mg/kg once every two days · subcutaneous · four weeksAs given in this study (mouse).
Source sentences
Summary
In addition, the submandibular glands from NMN-treated old mice had decreased acetylation, numbers of senescent cells, and levels of senescence-associated secretory phenotype (SASP) factors, which all increase with aging, as well as increased aquaporin5 (AQP5) mRNA expression.
1 context sentence(design, population, supporting numbers)
Summary · context
Young (16-week-old) and old (113-week-old) male mice were treated subcutaneously with saline or NMN (300 mg/kg) once every two days for four weeks and saliva secretion was measured.
Report a problemFND-3963307503
04AnimalAnimal study (in vivo)Mechanism
In old male mice, NMN decreased submandibular gland senescent cell numbers compared with saline.
In plain wordsIn old male mice, NMN reduced senescent cells in salivary glands compared with saline.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseSenescent cell number
Study
mousen: not reported in source
Old male mice
Comparator
Saline-treated old mice
Outcome group
Aging markers · Gastrointestinal
Studied dose
300 mg/kg once every two days · subcutaneous · four weeksAs given in this study (mouse).
Source sentences
Summary
In addition, the submandibular glands from NMN-treated old mice had decreased acetylation, numbers of senescent cells, and levels of senescence-associated secretory phenotype (SASP) factors, which all increase with aging, as well as increased aquaporin5 (AQP5) mRNA expression.
1 context sentence(design, population, supporting numbers)
Summary · context
Young (16-week-old) and old (113-week-old) male mice were treated subcutaneously with saline or NMN (300 mg/kg) once every two days for four weeks and saliva secretion was measured.
Report a problemFND-3963307504
05AnimalAnimal study (in vivo)Mechanism
In old male mice, NMN decreased submandibular gland SASP factor levels compared with saline.
In plain wordsIn old male mice, NMN reduced senescence-associated secretory factors in salivary glands compared with saline.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseSASP factor levels
Study
mousen: not reported in source
Old male mice
Comparator
Saline-treated old mice
Outcome group
Aging markers · Gastrointestinal
Studied dose
300 mg/kg once every two days · subcutaneous · four weeksAs given in this study (mouse).
Source sentences
Summary
In addition, the submandibular glands from NMN-treated old mice had decreased acetylation, numbers of senescent cells, and levels of senescence-associated secretory phenotype (SASP) factors, which all increase with aging, as well as increased aquaporin5 (AQP5) mRNA expression.
1 context sentence(design, population, supporting numbers)
Summary · context
Young (16-week-old) and old (113-week-old) male mice were treated subcutaneously with saline or NMN (300 mg/kg) once every two days for four weeks and saliva secretion was measured.
Report a problemFND-3963307505
06AnimalAnimal study (in vivo)Mechanism
In old male mice, NMN increased submandibular gland aquaporin5 mRNA expression compared with saline.
In plain wordsIn old male mice, NMN increased salivary gland aquaporin5 gene expression compared with saline.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseAquaporin5 mRNA expression
Study
mousen: not reported in source
Old male mice
Comparator
Saline-treated old mice
Outcome group
Receptor activity and mechanism · Gastrointestinal
Studied dose
300 mg/kg once every two days · subcutaneous · four weeksAs given in this study (mouse).
Source sentences
Summary
In addition, the submandibular glands from NMN-treated old mice had decreased acetylation, numbers of senescent cells, and levels of senescence-associated secretory phenotype (SASP) factors, which all increase with aging, as well as increased aquaporin5 (AQP5) mRNA expression.
1 context sentence(design, population, supporting numbers)
Summary · context
Young (16-week-old) and old (113-week-old) male mice were treated subcutaneously with saline or NMN (300 mg/kg) once every two days for four weeks and saliva secretion was measured.
Report a problemFND-3963307506

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

Keywords

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