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Study · Animal study (in vivo) · rat · 2024

3 results

The antidepressant-like effects of kisspeptin-10 are reversed by kisspeptin antagonist peptide 234 in male rats.

Serhatlioglu I, Kacar E, Yardimci A, Ulker Ertugrul N, Bulmus O, Ercan Z, Kelestimur H

Cellular and molecular biology (Noisy-le-Grand, France)24 Nov 2024

PMID39605118 (opens in a new tab)DOI10.14715/cmb/2024.70.10.13 (opens in a new tab)PepBankPUB-39605118
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, kisspeptin‑10 produced an antidepressant-like effect in a modified forced swimming test.

    In plain wordsIn male rats, kisspeptin‑10 had an antidepressant-like effect in a swimming test.

    Peptide
    Kisspeptin-10
    Outcome
    Direction not reportedAntidepressant-like effect in forced swimming test
    Study

    ratn: not reported in source

    Modified forced swimming test in male rats
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our results indicate that, in rats, the anti-depressant-like effects of KP-10 in a modified rat FST are mediated by GPR54 receptors, since the kisspeptin antagonist peptide 234 reversed kisspeptin-induced anti-depressant-like effects.
    1 context sentence
    Summary · context
    To test this concept, peptide 234 (P234), a kisspeptin antagonist, was given to the male rats, and its modulatory effect on the anti-depressant-like effects of kisspeptin was investigated by using a forced swimming test (FST).
  2. 02AnimalAnimal study (in vivo)Mechanism

    In male rats, the kisspeptin antagonist peptide 234 reversed the antidepressant-like effect of kisspeptin‑10, which points to GPR54 receptor mediation.

    In plain wordsIn male rats, a kisspeptin blocker reversed the antidepressant-like effect of kisspeptin‑10, which suggests the effect works through the GPR54 receptor.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableReversal of kisspeptin-10 antidepressant-like effect by kisspeptin antagonist P234
    Study

    ratn: not reported in source

    Modified forced swimming test in male rats
    Outcome group
    Receptor activity and mechanism · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our results indicate that, in rats, the anti-depressant-like effects of KP-10 in a modified rat FST are mediated by GPR54 receptors, since the kisspeptin antagonist peptide 234 reversed kisspeptin-induced anti-depressant-like effects.
    1 context sentence
    Summary · context
    To test this concept, peptide 234 (P234), a kisspeptin antagonist, was given to the male rats, and its modulatory effect on the anti-depressant-like effects of kisspeptin was investigated by using a forced swimming test (FST).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In male rats, the antidepressant-like effect of kisspeptin is mediated in part by an interaction with alpha-2 adrenergic and 5-HT2 serotonergic receptors.

    In plain wordsIn male rats, the antidepressant-like effect of kisspeptin seems to work partly through two other brain receptor systems.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableInvolvement of alpha-2 adrenergic and 5-HT2 serotonergic receptors
    Study

    ratn: not reported in source

    Modified forced swimming test in male rats
    Outcome group
    Receptor activity and mechanism · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our data also demonstrate that the anti-depressant-like effects of kisspeptin, at least in part, are mediated by an interaction of the alpha-2 adrenergic and 5-HT2 serotonergic receptors.
    2 context sentences
    Summary · context
    To investigate this, the agents yohimbine (Yoh), an alpha-2 adrenergic receptor antagonist, and cyproheptadine (Cry), a non-selective 5-HT2 serotonergic receptor antagonist, were administered in the experiments.
    Summary · context
    To test this concept, peptide 234 (P234), a kisspeptin antagonist, was given to the male rats, and its modulatory effect on the anti-depressant-like effects of kisspeptin was investigated by using a forced swimming test (FST).

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

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Publication types

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