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Study · Not a test of the peptide alone · 2025

3 results

Effect of elamipretide and methylprednisolone treatment on optic nerve, retina and brain damage in a methanol poisoning model: biochemical and histopathological evaluation.

Bulbul O, Mammadov R, Suleyman B, Kulaber A, Karaca Y, Yaman H, Yenilmez E, Sahin A, Ozer V

Cutaneous and ocular toxicology27 Nov 2024

PMID39601106 (opens in a new tab)DOI10.1080/15569527.2024.2430241 (opens in a new tab)PepBankPUB-39601106
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Elamipretide (SS-31).

  1. 01AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Efficacy outcome

    In rats with methanol poisoning, combined elamipretide and methylprednisolone gave a higher retinal degeneration score (less degeneration) than methanol alone.

    In plain wordsIn rats with methanol poisoning, elamipretide plus methylprednisolone together led to less retinal damage than no treatment.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseRetinal degeneration score
    Study

    ratn: not reported in source

    methotrexate plus methanol poisoning model
    Comparator
    MTX-M group
    Outcome group
    Neuroprotection · Eye

    Source sentences

    Summary
    In the MTX-M-MPZ-E group, the retinal degeneration score was higher than in MTX-M group (p = 0.002).
    2 context sentences
    Summary · context
    Retinal degeneration was assessed using a scoring system where higher scores indicate less degeneration, with a score of 5 representing normal structure and 1 reflecting severe degeneration.
    Summary · context
    This study aimed to biochemically and histopathologically evaluate the protective and therapeutic effects of elamipretide and methylprednisolone on methanol poisoning-induced brain, optic nerve, and retinal toxicity.

    In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).

  2. 02AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Efficacy outcome

    In rats with methanol poisoning, the retinal apoptosis index was lower with combined elamipretide and methylprednisolone than with methanol alone.

    In plain wordsIn rats with methanol poisoning, elamipretide plus methylprednisolone together led to less retinal cell death than no treatment.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseRetinal apoptosis index
    Study

    ratn: not reported in source

    methotrexate plus methanol poisoning model
    Comparator
    MTX-M group
    Outcome group
    Neuroprotection · Eye

    Source sentences

    Summary
    The apoptosis index in the retina was highest in MTX-M group, while it was lower in MTX-M-MPZ-E group compared to MTX-M group (p = 0.018).
    1 context sentence
    Summary · context
    This study aimed to biochemically and histopathologically evaluate the protective and therapeutic effects of elamipretide and methylprednisolone on methanol poisoning-induced brain, optic nerve, and retinal toxicity.

    In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).

  3. 03AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Efficacy outcome

    In rats with methanol poisoning, the caudatoputamen apoptosis index was lower with combined elamipretide and methylprednisolone than with methanol alone.

    In plain wordsIn rats with methanol poisoning, elamipretide plus methylprednisolone together led to less brain cell death than no treatment.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseCaudatoputamen apoptosis index
    Study

    ratn: not reported in source

    methotrexate plus methanol poisoning model
    Comparator
    MTX-M group
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    In addition, the apoptosis index in the caudatoputamen was lower in MTX-M-MPZ-E group compared to MTX-M group (p = 0.009).
    1 context sentence
    Summary · context
    This study aimed to biochemically and histopathologically evaluate the protective and therapeutic effects of elamipretide and methylprednisolone on methanol poisoning-induced brain, optic nerve, and retinal toxicity.

    In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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