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Study · Measured the body's own peptide · 2024

2 results

Comparison of the Mitophagy and Apoptosis Related Gene Expressions in Waste Embryo Culture Medium of Female Infertility Types.

Kütük D, Öner Ç, Başar M, Akcay B, Olcay İO, Çolak E, Selam B, Cincik M

Life (Basel, Switzerland)19 Nov 2024Cited by 1 (Europe PMC)

PMID39598305 (opens in a new tab)PMCIDPMC11595419 (opens in a new tab)DOI10.3390/life14111507 (opens in a new tab)PepBankPUB-39598305
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Summary

Mitochondria is an important organelle for the oocyte-to-embryo transition in the early embryonic development period. The oocyte uses mitochondria functionally and its mitochondrial DNA (mtDNA) content as the main energy source in the embryo development at the preimplantation stage. The aim of this study is to compare mitophagic, apoptotic and humanin gene expressions from the culture medium fluid in which embryos are developed and monitored among normoresponder (NOR), polycystic ovary syndrome (PCOS), young and older patients with poor ovarian reserve (POR). The study groups consisted of infertile patients who applied to the Bahçeci Umut IVF Center as NOR (Control), PCOS, POR-Advanced (POR-A) and POR-Young (POR-Y). After the isolation of total RNA from the collected samples, MFN1, MFN2, PINK1, PARKIN, SMN1, SMN2, p53 and Humanin gene expressions were determined by Real Time-PCR. The average age of only the POR-A was determined to be higher than the NOR (p < 0.001). The MFN1, SMN2 (p p p < 0.05), in the POR-Y compared to the NOR. A decrease in MFN2, PARKIN (p p < 0.001). Furthermore, a decrease was observed in MFN2, PINK1 (p p < 0.05). The current data are the first in the literature determining the apoptotic and mitophagic status of the oocyte. The current results prove that waste embryo culture fluid may provide a non-invasive profile for important cellular parameters such as mitochondrial dysfunction in female infertility. The evaluation of significant cellular parameters can be performed much earlier without any intervention into the embryo.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In embryo culture medium from infertile patients, Humanin gene expression was higher in the young poor ovarian reserve group than in the normoresponder control group.

    In plain wordsIn fluid from embryo cultures, the body's own humanin gene activity was higher in young women with poor ovarian reserve than in controls.

    Peptide
    Humanin
    Outcome
    IncreaseHumanin gene expression in embryo culture medium
    Study

    n: not reported in source

    Comparator
    NOR (control)
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    The MFN1, SMN2 (p p p < 0.05), in the POR-Y compared to the NOR.
    1 context sentence
    Summary · context
    The study groups consisted of infertile patients who applied to the Bahçeci Umut IVF Center as NOR (Control), PCOS, POR-Advanced (POR-A) and POR-Young (POR-Y).

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In embryo culture medium from infertile patients, Humanin gene expression was lower than in the normoresponder control group, in a group that the abstract sentence does not name.

    In plain wordsIn fluid from embryo cultures, the body's own humanin gene activity was lower in one infertility group than in controls.

    Peptide
    Humanin
    Outcome
    DecreaseHumanin gene expression in embryo culture medium
    Study

    n: not reported in source

    Comparator
    NOR (control)
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Furthermore, a decrease was observed in MFN2, PINK1 (p p < 0.05).
    1 context sentence
    Summary · context
    The study groups consisted of infertile patients who applied to the Bahçeci Umut IVF Center as NOR (Control), PCOS, POR-Advanced (POR-A) and POR-Young (POR-Y).

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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