Nicotinamide mononucleotide improves the ovarian reserve of POI by inhibiting NLRP3-mediated pyroptosis of ovarian granulosa cells.

Ma Y, Nong W, Zhong O, Liu K, Lei S, Wang C, Chen X, Lei X

Journal of ovarian research26 Nov 2024Cited by 10 (Europe PMC)

PMID39593096PMCIDPMC11590476DOI10.1186/s13048-024-01534-wPepBankPUB-39593096

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Summary

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Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In POI rats, NMN improved blood hormone levels compared with saline treatment.
In plain wordsIn rats with ovarian insufficiency, NMN improved blood hormone levels compared with saline.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
Direction not reportedBlood hormone levels
Study
ratn = 20
Cyclophosphamide-induced premature ovarian insufficiency
Comparator
Saline-treated POI rats
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
500 mg/kg/day · 21 consecutive daysAs given in this study (rat).
Source sentences
Summary
In POI rats, NMN treatments can improve blood hormone levels and partially improve the number of follicles, enhance ovarian reserve function and ovarian index.
2 context sentences(design, population, supporting numbers)
Summary · context
Thirty female Sprague Dawley rats were randomly divided into a control group (n = 10) and a POI group (n = 20).
Summary · context
Then the POI group was divided into two groups: the CTX-POI group (n = 10), which was given saline; and the CTX-POI + NMN group (n = 10), which was given NMN at a dose of 500 mg/kg/day for 21 consecutive days.
Report a problemFND-3959309601
02AnimalAnimal study (in vivo)Efficacy outcome
In POI rats, NMN partially improved follicle number compared with saline treatment.
In plain wordsIn rats with ovarian insufficiency, NMN partly improved follicle number compared with saline.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseFollicle number
Study
ratn = 20
Cyclophosphamide-induced premature ovarian insufficiency
Comparator
Saline-treated POI rats
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
500 mg/kg/day · 21 consecutive daysAs given in this study (rat).
Source sentences
Summary
In POI rats, NMN treatments can improve blood hormone levels and partially improve the number of follicles, enhance ovarian reserve function and ovarian index.
2 context sentences(design, population, supporting numbers)
Summary · context
Thirty female Sprague Dawley rats were randomly divided into a control group (n = 10) and a POI group (n = 20).
Summary · context
Then the POI group was divided into two groups: the CTX-POI group (n = 10), which was given saline; and the CTX-POI + NMN group (n = 10), which was given NMN at a dose of 500 mg/kg/day for 21 consecutive days.
Report a problemFND-3959309602
03AnimalAnimal study (in vivo)Efficacy outcome
In POI rats, NMN enhanced ovarian reserve function compared with saline treatment.
In plain wordsIn rats with ovarian insufficiency, NMN improved ovarian reserve function compared with saline.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseOvarian reserve function
Study
ratn = 20
Cyclophosphamide-induced premature ovarian insufficiency
Comparator
Saline-treated POI rats
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
500 mg/kg/day · 21 consecutive daysAs given in this study (rat).
Source sentences
Summary
In POI rats, NMN treatments can improve blood hormone levels and partially improve the number of follicles, enhance ovarian reserve function and ovarian index.
2 context sentences(design, population, supporting numbers)
Summary · context
Thirty female Sprague Dawley rats were randomly divided into a control group (n = 10) and a POI group (n = 20).
Summary · context
Then the POI group was divided into two groups: the CTX-POI group (n = 10), which was given saline; and the CTX-POI + NMN group (n = 10), which was given NMN at a dose of 500 mg/kg/day for 21 consecutive days.
Report a problemFND-3959309603
04AnimalAnimal study (in vivo)Efficacy outcome
In POI rats, NMN enhanced the ovarian index compared with saline treatment.
In plain wordsIn rats with ovarian insufficiency, NMN increased the ovarian index compared with saline.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseOvarian index
Study
ratn = 20
Cyclophosphamide-induced premature ovarian insufficiency
Comparator
Saline-treated POI rats
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
500 mg/kg/day · 21 consecutive daysAs given in this study (rat).
Source sentences
Summary
In POI rats, NMN treatments can improve blood hormone levels and partially improve the number of follicles, enhance ovarian reserve function and ovarian index.
2 context sentences(design, population, supporting numbers)
Summary · context
Thirty female Sprague Dawley rats were randomly divided into a control group (n = 10) and a POI group (n = 20).
Summary · context
Then the POI group was divided into two groups: the CTX-POI group (n = 10), which was given saline; and the CTX-POI + NMN group (n = 10), which was given NMN at a dose of 500 mg/kg/day for 21 consecutive days.
Report a problemFND-3959309604
05AnimalAnimal study (in vivo)Mechanism
In POI rats, NMN increased ovarian NAD levels.
In plain wordsIn rats with ovarian insufficiency, NMN increased ovarian NAD levels compared with saline.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseNAD levels
Study
ratn = 20
Cyclophosphamide-induced premature ovarian insufficiency
Comparator
Saline-treated POI rats
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
500 mg/kg/day · 21 consecutive daysAs given in this study (rat).
Source sentences
Summary
The evidence is that the increase in NAD⁺ levels and the activation of SIRT2 expression can reduce the expression of NLRP3, Gasdermin D (GSDMD), Caspase-1, IL-18, and IL-1β in the ovary.
2 context sentences(design, population, supporting numbers)
Summary · context
Thirty female Sprague Dawley rats were randomly divided into a control group (n = 10) and a POI group (n = 20).
Summary · context
Then the POI group was divided into two groups: the CTX-POI group (n = 10), which was given saline; and the CTX-POI + NMN group (n = 10), which was given NMN at a dose of 500 mg/kg/day for 21 consecutive days.
Report a problemFND-3959309605
06AnimalAnimal study (in vivo)Mechanism
In POI rats, NMN activated ovarian SIRT2 expression.
In plain wordsIn rats with ovarian insufficiency, NMN increased ovarian SIRT2 expression compared with saline.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseSIRT2 expression
Study
ratn = 20
Cyclophosphamide-induced premature ovarian insufficiency
Comparator
Saline-treated POI rats
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
500 mg/kg/day · 21 consecutive daysAs given in this study (rat).
Source sentences
Summary
The evidence is that the increase in NAD⁺ levels and the activation of SIRT2 expression can reduce the expression of NLRP3, Gasdermin D (GSDMD), Caspase-1, IL-18, and IL-1β in the ovary.
2 context sentences(design, population, supporting numbers)
Summary · context
Thirty female Sprague Dawley rats were randomly divided into a control group (n = 10) and a POI group (n = 20).
Summary · context
Then the POI group was divided into two groups: the CTX-POI group (n = 10), which was given saline; and the CTX-POI + NMN group (n = 10), which was given NMN at a dose of 500 mg/kg/day for 21 consecutive days.
Report a problemFND-3959309606
07AnimalAnimal study (in vivo)Mechanism
In POI rats, NMN reduced ovarian NLRP3 expression.
In plain wordsIn rats with ovarian insufficiency, NMN reduced ovarian NLRP3 expression compared with saline.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseNLRP3 expression
Study
ratn = 20
Cyclophosphamide-induced premature ovarian insufficiency
Comparator
Saline-treated POI rats
Outcome group
Inflammation markers · Reproductive and sexual health
Studied dose
500 mg/kg/day · 21 consecutive daysAs given in this study (rat).
Source sentences
Summary
The evidence is that the increase in NAD⁺ levels and the activation of SIRT2 expression can reduce the expression of NLRP3, Gasdermin D (GSDMD), Caspase-1, IL-18, and IL-1β in the ovary.
2 context sentences(design, population, supporting numbers)
Summary · context
Thirty female Sprague Dawley rats were randomly divided into a control group (n = 10) and a POI group (n = 20).
Summary · context
Then the POI group was divided into two groups: the CTX-POI group (n = 10), which was given saline; and the CTX-POI + NMN group (n = 10), which was given NMN at a dose of 500 mg/kg/day for 21 consecutive days.
Report a problemFND-3959309607
08AnimalAnimal study (in vivo)Mechanism
In POI rats, NMN reduced ovarian Gasdermin D expression.
In plain wordsIn rats with ovarian insufficiency, NMN reduced ovarian Gasdermin D expression compared with saline.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseGasdermin D expression
Study
ratn = 20
Cyclophosphamide-induced premature ovarian insufficiency
Comparator
Saline-treated POI rats
Outcome group
Inflammation markers · Reproductive and sexual health
Studied dose
500 mg/kg/day · 21 consecutive daysAs given in this study (rat).
Source sentences
Summary
The evidence is that the increase in NAD⁺ levels and the activation of SIRT2 expression can reduce the expression of NLRP3, Gasdermin D (GSDMD), Caspase-1, IL-18, and IL-1β in the ovary.
2 context sentences(design, population, supporting numbers)
Summary · context
Thirty female Sprague Dawley rats were randomly divided into a control group (n = 10) and a POI group (n = 20).
Summary · context
Then the POI group was divided into two groups: the CTX-POI group (n = 10), which was given saline; and the CTX-POI + NMN group (n = 10), which was given NMN at a dose of 500 mg/kg/day for 21 consecutive days.
Report a problemFND-3959309608
09AnimalAnimal study (in vivo)Mechanism
In POI rats, NMN reduced ovarian Caspase-1 expression.
In plain wordsIn rats with ovarian insufficiency, NMN reduced ovarian Caspase-1 expression compared with saline.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseCaspase-1 expression
Study
ratn = 20
Cyclophosphamide-induced premature ovarian insufficiency
Comparator
Saline-treated POI rats
Outcome group
Inflammation markers · Reproductive and sexual health
Studied dose
500 mg/kg/day · 21 consecutive daysAs given in this study (rat).
Source sentences
Summary
The evidence is that the increase in NAD⁺ levels and the activation of SIRT2 expression can reduce the expression of NLRP3, Gasdermin D (GSDMD), Caspase-1, IL-18, and IL-1β in the ovary.
2 context sentences(design, population, supporting numbers)
Summary · context
Thirty female Sprague Dawley rats were randomly divided into a control group (n = 10) and a POI group (n = 20).
Summary · context
Then the POI group was divided into two groups: the CTX-POI group (n = 10), which was given saline; and the CTX-POI + NMN group (n = 10), which was given NMN at a dose of 500 mg/kg/day for 21 consecutive days.
Report a problemFND-3959309609
10AnimalAnimal study (in vivo)Mechanism
In POI rats, NMN reduced ovarian IL-18 expression.
In plain wordsIn rats with ovarian insufficiency, NMN reduced ovarian IL-18 expression compared with saline.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseIL-18 expression
Study
ratn = 20
Cyclophosphamide-induced premature ovarian insufficiency
Comparator
Saline-treated POI rats
Outcome group
Inflammation markers · Reproductive and sexual health
Studied dose
500 mg/kg/day · 21 consecutive daysAs given in this study (rat).
Source sentences
Summary
The evidence is that the increase in NAD⁺ levels and the activation of SIRT2 expression can reduce the expression of NLRP3, Gasdermin D (GSDMD), Caspase-1, IL-18, and IL-1β in the ovary.
2 context sentences(design, population, supporting numbers)
Summary · context
Thirty female Sprague Dawley rats were randomly divided into a control group (n = 10) and a POI group (n = 20).
Summary · context
Then the POI group was divided into two groups: the CTX-POI group (n = 10), which was given saline; and the CTX-POI + NMN group (n = 10), which was given NMN at a dose of 500 mg/kg/day for 21 consecutive days.
Report a problemFND-3959309610
11AnimalAnimal study (in vivo)Mechanism
In POI rats, NMN reduced ovarian IL-1β expression.
In plain wordsIn rats with ovarian insufficiency, NMN reduced ovarian IL-1β expression compared with saline.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseIL-1β expression
Study
ratn = 20
Cyclophosphamide-induced premature ovarian insufficiency
Comparator
Saline-treated POI rats
Outcome group
Inflammation markers · Reproductive and sexual health
Studied dose
500 mg/kg/day · 21 consecutive daysAs given in this study (rat).
Source sentences
Summary
The evidence is that the increase in NAD⁺ levels and the activation of SIRT2 expression can reduce the expression of NLRP3, Gasdermin D (GSDMD), Caspase-1, IL-18, and IL-1β in the ovary.
2 context sentences(design, population, supporting numbers)
Summary · context
Thirty female Sprague Dawley rats were randomly divided into a control group (n = 10) and a POI group (n = 20).
Summary · context
Then the POI group was divided into two groups: the CTX-POI group (n = 10), which was given saline; and the CTX-POI + NMN group (n = 10), which was given NMN at a dose of 500 mg/kg/day for 21 consecutive days.
Report a problemFND-3959309611

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PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

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