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Study · Animal study (in vivo) · mouse · 2025

6 results

Inhaled exogenous thymosin beta 4 suppresses bleomycin-induced pulmonary fibrosis in mice via TGF-β1 signalling pathway.

Yu R, Li S, Chen L, Hu E, Chai D, Liu Z, Zhang Q, Mao Y, Zhai Y, Li K, Liu Y, Li X, Zhou H, Yang C, Xu J

The Journal of pharmacy and pharmacology1 Apr 2025

PMID39579076 (opens in a new tab)DOI10.1093/jpp/rgae143 (opens in a new tab)PepBankPUB-39579076
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with bleomycin-induced pulmonary fibrosis, aerosol rhTβ4 alleviated fibrosis at different stages.

    In plain wordsIn mice with lung scarring, inhaled Tβ4 reduced the scarring at different stages.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseBleomycin-induced pulmonary fibrosis
    Study

    mousen: not reported in source

    bleomycin-induced pulmonary fibrosis
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated · nebulizationAs given in this study (mouse).

    Source sentences

    Summary
    Aerosol administration of rhTβ4 could alleviate bleomycin-induced pulmonary fibrosis in mice at different stages of fibrosis.
    1 context sentence
    Summary · context
    Pulmonary fibrosis was induced in mice with bleomycin, and rhTβ4 was administrated by nebulization following three strategies: early dosing, mid-term dosing, and late dosing.
  2. 02LabIn vitro (cells)Efficacy outcome

    In lung fibroblasts in vitro, rhTβ4 suppressed proliferation via the TGF-β1 signalling pathway.

    In plain wordsIn lab tests on lung cells, Tβ4 reduced lung fibroblast growth.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseLung fibroblast proliferation
    Study

    n: not reported in source

    lung fibroblasts
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    rhTβ4 could suppress lung fibroblasts from proliferating
    1 context sentence
    Summary · context
    In vitro, the effects of rhTβ4 on fibroblast and lung epithelial cell phenotypes, as well as the TGF-β1 pathway, were evaluated.
  3. 03LabIn vitro (cells)Efficacy outcome

    In lung fibroblasts in vitro, rhTβ4 suppressed migration via the TGF-β1 signalling pathway.

    In plain wordsIn lab tests on lung cells, Tβ4 reduced lung fibroblast movement.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseLung fibroblast migration
    Study

    n: not reported in source

    lung fibroblasts
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    rhTβ4 could suppress lung fibroblasts from proliferating, migrating
    1 context sentence
    Summary · context
    In vitro, the effects of rhTβ4 on fibroblast and lung epithelial cell phenotypes, as well as the TGF-β1 pathway, were evaluated.
  4. 04LabIn vitro (cells)Efficacy outcome

    In lung fibroblasts in vitro, rhTβ4 suppressed activation via the TGF-β1 signalling pathway.

    In plain wordsIn lab tests on lung cells, Tβ4 reduced lung fibroblast activation.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseLung fibroblast activation
    Study

    n: not reported in source

    lung fibroblasts
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    rhTβ4 could suppress lung fibroblasts from proliferating, migrating, and activation
    1 context sentence
    Summary · context
    In vitro, the effects of rhTβ4 on fibroblast and lung epithelial cell phenotypes, as well as the TGF-β1 pathway, were evaluated.
  5. 05LabIn vitro (cells)Mechanism

    In lung fibroblasts in vitro, rhTβ4 acted by regulating the TGF-β1 signalling pathway.

    In plain wordsIn lab tests on lung cells, Tβ4 acted through the TGF-β1 signalling pathway.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableTGF-β1 signalling pathway regulation
    Study

    n: not reported in source

    lung fibroblasts
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    via regulating the TGF-β1 signalling pathway
    1 context sentence
    Summary · context
    In vitro, the effects of rhTβ4 on fibroblast and lung epithelial cell phenotypes, as well as the TGF-β1 pathway, were evaluated.
  6. 06LabIn vitro (cells)Efficacy outcome

    In pulmonary epithelial cells in vitro, rhTβ4 inhibited the epithelial-mesenchymal transition-like process.

    In plain wordsIn lab tests on lung lining cells, Tβ4 blocked a change linked to scarring.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseEpithelial-mesenchymal transition-like process
    Study

    n: not reported in source

    pulmonary epithelial cells
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro, rhTβ4 also inhibited the epithelial-mesenchymal transition-like process of pulmonary epithelial cells.
    1 context sentence
    Summary · context
    In vitro, the effects of rhTβ4 on fibroblast and lung epithelial cell phenotypes, as well as the TGF-β1 pathway, were evaluated.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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