TMSB4X is a regulator of inflammation-associated ferroptosis, and promotes the proliferation, migration and invasion of hepatocellular carcinoma cells.

Tang L, Jin Y, Wang J, Lu X, Xu M, Xiang M

Discover oncology18 Nov 2024Cited by 6 (Europe PMC)

PMID39556271PMCIDPMC11573954DOI10.1007/s12672-024-01558-0PepBankPUB-39556271

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyOther
In TCGA hepatocellular carcinoma samples, TMSB4X was highly expressed and was the most important gene for classifying risk groups.
In plain wordsIn liver cancer samples, the body's own thymosin beta‑4 gene (TMSB4X) was highly active and mattered most for sorting patients by risk.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseTMSB4X expression in HCC samples
Study
n: not reported in source
Outcome group
Tumor growth · Cancer
Source sentences
Summary
TMSB4X was the most important gene which dominated the classification, and it was highly expressed in HCC samples.
1 context sentence(design, population, supporting numbers)
Summary · context
RNA sequencing data and clinicopathologic information of HCC patients were downloaded from the Cancer Genome Atlas (TCGA) database.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3955627101

Studies that did not test the peptide alone3

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

02LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Efficacy outcome
In hepatocellular carcinoma cell lines, TMSB4X promoted cell viability.
In plain wordsIn liver cancer cells, the TMSB4X gene increased cell survival and growth.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseHCC cell viability
Study
humann: not reported in source
HCC cell lines with TMSB4X overexpression or knockdown
Outcome group
Tumor growth · Cancer
Source sentences
Summary
TMSB4X promoted the viability, migration and invasion, and repressed ferroptosis of HCC cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Thymosin beta 4 X-linked (TMSB4X) was overexpressed or knocked down in HCC cell lines, and then qPCR, CCK-8, Transwell, flow cytometery assays were performed to detect the change of HCC cells' phenotypes, and Western blot was used to detect the change of ferroptosis markers.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-3955627102
03LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Efficacy outcome
In hepatocellular carcinoma cell lines, TMSB4X promoted migration and invasion.
In plain wordsIn liver cancer cells, the TMSB4X gene increased movement and invasion.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseHCC cell migration and invasion
Study
humann: not reported in source
HCC cell lines with TMSB4X overexpression or knockdown
Outcome group
Tumor growth · Cancer
Source sentences
Summary
TMSB4X promoted the viability, migration and invasion, and repressed ferroptosis of HCC cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Thymosin beta 4 X-linked (TMSB4X) was overexpressed or knocked down in HCC cell lines, and then qPCR, CCK-8, Transwell, flow cytometery assays were performed to detect the change of HCC cells' phenotypes, and Western blot was used to detect the change of ferroptosis markers.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-3955627103
04LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism
In hepatocellular carcinoma cell lines, TMSB4X repressed ferroptosis.
In plain wordsIn liver cancer cells, the TMSB4X gene reduced a form of cell death called ferroptosis.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseFerroptosis in HCC cells
Study
humann: not reported in source
HCC cell lines with TMSB4X overexpression or knockdown
Outcome group
Tumor growth · Cancer
Source sentences
Summary
TMSB4X promoted the viability, migration and invasion, and repressed ferroptosis of HCC cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Thymosin beta 4 X-linked (TMSB4X) was overexpressed or knocked down in HCC cell lines, and then qPCR, CCK-8, Transwell, flow cytometery assays were performed to detect the change of HCC cells' phenotypes, and Western blot was used to detect the change of ferroptosis markers.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-3955627104

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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Keywords

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