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Study · Animal study (in vivo) · mouse · 2025

7 results

Humanin attenuates metabolic, toxic, and traumatic neuropathic pain in mice by protecting against oxidative stress and increasing inflammatory cytokine.

Bilgin B, Hekim MG, Bulut F, Kelestemur MM, Adam M, Ozcan S, Canpolat S, Ayar A, Ozcan M

Neuropharmacology5 Nov 2024Cited by 5 (Europe PMC)

PMID39510375 (opens in a new tab)DOI10.1016/j.neuropharm.2024.110207 (opens in a new tab)PepBankPUB-39510375
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with STZ-induced neuropathic pain, humanin significantly increased pain threshold values versus controls over 15 days.

    In plain wordsIn mice with diabetes-type nerve pain, humanin raised the pain threshold compared with control mice.

    Peptide
    Humanin
    Outcome
    IncreasePain threshold in STZ-induced metabolic neuropathic pain
    Study

    mousen: not reported in source

    Murine neuropathic pain models (STZ, oxaliplatin, sciatic nerve cuff)
    Comparator
    Control groups
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    4 mg/kg · intraperitoneal · 15 daysAs given in this study (mouse).

    Source sentences

    Summary
    In neuropathic pain-induced mice, humanin administration resulted in a statistically significant increase in pain threshold values in the STZ + Humanin, OXA + Humanin, and cuff + Humanin groups compared to their respective control groups (P < 0.05) over 15 days.
    1 context sentence
    Summary · context
    Humanin (4 mg/kg) was administered intraperitoneally (i.p.) to BALB/c male mice with induced neuropathic pain over a period of 15 days, with pain thresholds assessed using hot plate, cold plate, and Von Frey tests.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with oxaliplatin-induced neuropathic pain, humanin significantly increased pain threshold values versus controls over 15 days.

    In plain wordsIn mice with chemotherapy-type nerve pain, humanin raised the pain threshold compared with control mice.

    Peptide
    Humanin
    Outcome
    IncreasePain threshold in oxaliplatin-induced toxic neuropathic pain
    Study

    mousen: not reported in source

    Murine neuropathic pain models (STZ, oxaliplatin, sciatic nerve cuff)
    Comparator
    Control groups
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    4 mg/kg · intraperitoneal · 15 daysAs given in this study (mouse).

    Source sentences

    Summary
    In neuropathic pain-induced mice, humanin administration resulted in a statistically significant increase in pain threshold values in the STZ + Humanin, OXA + Humanin, and cuff + Humanin groups compared to their respective control groups (P < 0.05) over 15 days.
    1 context sentence
    Summary · context
    Humanin (4 mg/kg) was administered intraperitoneally (i.p.) to BALB/c male mice with induced neuropathic pain over a period of 15 days, with pain thresholds assessed using hot plate, cold plate, and Von Frey tests.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with sciatic nerve cuff-induced neuropathic pain, humanin significantly increased pain threshold values versus controls over 15 days.

    In plain wordsIn mice with nerve-injury pain, humanin raised the pain threshold compared with control mice.

    Peptide
    Humanin
    Outcome
    IncreasePain threshold in cuff-induced traumatic neuropathic pain
    Study

    mousen: not reported in source

    Murine neuropathic pain models (STZ, oxaliplatin, sciatic nerve cuff)
    Comparator
    Control groups
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    4 mg/kg · intraperitoneal · 15 daysAs given in this study (mouse).

    Source sentences

    Summary
    In neuropathic pain-induced mice, humanin administration resulted in a statistically significant increase in pain threshold values in the STZ + Humanin, OXA + Humanin, and cuff + Humanin groups compared to their respective control groups (P < 0.05) over 15 days.
    1 context sentence
    Summary · context
    Humanin (4 mg/kg) was administered intraperitoneally (i.p.) to BALB/c male mice with induced neuropathic pain over a period of 15 days, with pain thresholds assessed using hot plate, cold plate, and Von Frey tests.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice with neuropathic pain, humanin treatment significantly elevated antioxidant enzyme levels versus controls.

    In plain wordsIn mice with nerve pain, humanin raised antioxidant enzyme levels compared with control mice.

    Peptide
    Humanin
    Outcome
    IncreaseSerum antioxidant enzyme levels
    Study

    mousen: not reported in source

    Murine neuropathic pain models (STZ, oxaliplatin, sciatic nerve cuff)
    Comparator
    Control groups
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    4 mg/kg · intraperitoneal · 15 daysAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, humanin treatment significantly elevated antioxidant enzyme levels and anti-inflammatory cytokine concentrations, while reducing oxidative stress markers and pro-inflammatory cytokine levels compared to control groups (P < 0.01).
    1 context sentence
    Summary · context
    Humanin (4 mg/kg) was administered intraperitoneally (i.p.) to BALB/c male mice with induced neuropathic pain over a period of 15 days, with pain thresholds assessed using hot plate, cold plate, and Von Frey tests.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice with neuropathic pain, humanin treatment significantly elevated anti-inflammatory cytokine concentrations versus controls.

    In plain wordsIn mice with nerve pain, humanin raised anti-inflammatory cytokines compared with control mice.

    Peptide
    Humanin
    Outcome
    IncreaseSerum anti-inflammatory cytokine concentrations
    Study

    mousen: not reported in source

    Murine neuropathic pain models (STZ, oxaliplatin, sciatic nerve cuff)
    Comparator
    Control groups
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    4 mg/kg · intraperitoneal · 15 daysAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, humanin treatment significantly elevated antioxidant enzyme levels and anti-inflammatory cytokine concentrations, while reducing oxidative stress markers and pro-inflammatory cytokine levels compared to control groups (P < 0.01).
    1 context sentence
    Summary · context
    Humanin (4 mg/kg) was administered intraperitoneally (i.p.) to BALB/c male mice with induced neuropathic pain over a period of 15 days, with pain thresholds assessed using hot plate, cold plate, and Von Frey tests.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mice with neuropathic pain, humanin treatment significantly reduced oxidative stress markers versus controls.

    In plain wordsIn mice with nerve pain, humanin lowered markers of oxidative stress compared with control mice.

    Peptide
    Humanin
    Outcome
    DecreaseSerum oxidative stress markers
    Study

    mousen: not reported in source

    Murine neuropathic pain models (STZ, oxaliplatin, sciatic nerve cuff)
    Comparator
    Control groups
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    4 mg/kg · intraperitoneal · 15 daysAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, humanin treatment significantly elevated antioxidant enzyme levels and anti-inflammatory cytokine concentrations, while reducing oxidative stress markers and pro-inflammatory cytokine levels compared to control groups (P < 0.01).
    1 context sentence
    Summary · context
    Humanin (4 mg/kg) was administered intraperitoneally (i.p.) to BALB/c male mice with induced neuropathic pain over a period of 15 days, with pain thresholds assessed using hot plate, cold plate, and Von Frey tests.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In mice with neuropathic pain, humanin treatment significantly reduced pro-inflammatory cytokine levels versus controls.

    In plain wordsIn mice with nerve pain, humanin lowered pro-inflammatory cytokines compared with control mice.

    Peptide
    Humanin
    Outcome
    DecreaseSerum pro-inflammatory cytokine levels
    Study

    mousen: not reported in source

    Murine neuropathic pain models (STZ, oxaliplatin, sciatic nerve cuff)
    Comparator
    Control groups
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    4 mg/kg · intraperitoneal · 15 daysAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, humanin treatment significantly elevated antioxidant enzyme levels and anti-inflammatory cytokine concentrations, while reducing oxidative stress markers and pro-inflammatory cytokine levels compared to control groups (P < 0.01).
    1 context sentence
    Summary · context
    Humanin (4 mg/kg) was administered intraperitoneally (i.p.) to BALB/c male mice with induced neuropathic pain over a period of 15 days, with pain thresholds assessed using hot plate, cold plate, and Von Frey tests.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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