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Study · Animal study (in vivo) · mouse · 2025

9 results

Long-Term Administration of Nicotinamide Mononucleotide Mitigates High-Fat-Diet-Induced Physiological Decline in Aging Mice.

Zhou AJ, Xiong ZE, Wang L, Chen XX, Wang ZP, Zhang YD, Chen WW, Cai XL, Xu YL, Rong S, Wang T

The Journal of nutrition17 Oct 2024Cited by 5 (Europe PMC)

PMID39424071 (opens in a new tab)DOI10.1016/j.tjnut.2024.10.017 (opens in a new tab)PepBankPUB-39424071
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In aging mice fed a high-fat diet, NMN increased NAD+ levels.

    In plain wordsIn mice fed a high-fat diet, NMN increased NAD+ levels.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseNAD+ levels
    Study

    mousen: not reported in source

    Aging mice fed a high-fat diet
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    400 mg/kg · drinking water · 7 moAs given in this study (mouse).

    Source sentences

    Summary
    We found that NMN supplementation increased NAD+ levels and ultimately attenuated age- and diet-related physiological decline in mice.
    1 context sentence
    Summary · context
    Mice at 14 mo of age were fed an HFD, and NMN was added to their drinking water at a dose of 400 mg/kg for 7 mo.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In aging mice, NMN attenuated age- and diet-related physiological decline.

    In plain wordsIn mice, NMN reduced age- and diet-related decline.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreasePhysiological decline
    Study

    mousen: not reported in source

    Aging mice fed a high-fat diet
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    400 mg/kg · drinking water · 7 moAs given in this study (mouse).

    Source sentences

    Summary
    We found that NMN supplementation increased NAD+ levels and ultimately attenuated age- and diet-related physiological decline in mice.
    1 context sentence
    Summary · context
    Mice at 14 mo of age were fed an HFD, and NMN was added to their drinking water at a dose of 400 mg/kg for 7 mo.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In aging mice, NMN inhibited high-fat-diet-induced obesity.

    In plain wordsIn mice, NMN reduced obesity caused by a high-fat diet.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseObesity
    Study

    mousen: not reported in source

    Aging mice fed a high-fat diet
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    400 mg/kg · drinking water · 7 moAs given in this study (mouse).

    Source sentences

    Summary
    NMN inhibited HFD-induced obesity, promoted physical activity, improved glucose and lipid metabolism, improved skeletal muscle function and renal damage, as well as mitigated the senescence and inflammaging as demonstrated by p16, interleukin 1β, and tumor necrosis factor α levels.
    1 context sentence
    Summary · context
    Mice at 14 mo of age were fed an HFD, and NMN was added to their drinking water at a dose of 400 mg/kg for 7 mo.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In aging mice fed a high-fat diet, NMN promoted physical activity.

    In plain wordsIn mice fed a high-fat diet, NMN increased physical activity.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreasePhysical activity
    Study

    mousen: not reported in source

    Aging mice fed a high-fat diet
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    400 mg/kg · drinking water · 7 moAs given in this study (mouse).

    Source sentences

    Summary
    NMN inhibited HFD-induced obesity, promoted physical activity, improved glucose and lipid metabolism, improved skeletal muscle function and renal damage, as well as mitigated the senescence and inflammaging as demonstrated by p16, interleukin 1β, and tumor necrosis factor α levels.
    1 context sentence
    Summary · context
    Mice at 14 mo of age were fed an HFD, and NMN was added to their drinking water at a dose of 400 mg/kg for 7 mo.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In aging mice fed a high-fat diet, NMN improved glucose metabolism.

    In plain wordsIn mice fed a high-fat diet, NMN improved glucose metabolism.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    MixedGlucose metabolism
    Study

    mousen: not reported in source

    Aging mice fed a high-fat diet
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    400 mg/kg · drinking water · 7 moAs given in this study (mouse).

    Source sentences

    Summary
    NMN inhibited HFD-induced obesity, promoted physical activity, improved glucose and lipid metabolism, improved skeletal muscle function and renal damage, as well as mitigated the senescence and inflammaging as demonstrated by p16, interleukin 1β, and tumor necrosis factor α levels.
    1 context sentence
    Summary · context
    Mice at 14 mo of age were fed an HFD, and NMN was added to their drinking water at a dose of 400 mg/kg for 7 mo.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In aging mice fed a high-fat diet, NMN improved lipid metabolism.

    In plain wordsIn mice fed a high-fat diet, NMN improved fat metabolism.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    MixedLipid metabolism
    Study

    mousen: not reported in source

    Aging mice fed a high-fat diet
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    400 mg/kg · drinking water · 7 moAs given in this study (mouse).

    Source sentences

    Summary
    NMN inhibited HFD-induced obesity, promoted physical activity, improved glucose and lipid metabolism, improved skeletal muscle function and renal damage, as well as mitigated the senescence and inflammaging as demonstrated by p16, interleukin 1β, and tumor necrosis factor α levels.
    1 context sentence
    Summary · context
    Mice at 14 mo of age were fed an HFD, and NMN was added to their drinking water at a dose of 400 mg/kg for 7 mo.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In aging mice fed a high-fat diet, NMN improved skeletal muscle function.

    In plain wordsIn mice fed a high-fat diet, NMN improved muscle function.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    MixedSkeletal muscle function
    Study

    mousen: not reported in source

    Aging mice fed a high-fat diet
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    400 mg/kg · drinking water · 7 moAs given in this study (mouse).

    Source sentences

    Summary
    NMN inhibited HFD-induced obesity, promoted physical activity, improved glucose and lipid metabolism, improved skeletal muscle function and renal damage, as well as mitigated the senescence and inflammaging as demonstrated by p16, interleukin 1β, and tumor necrosis factor α levels.
    1 context sentence
    Summary · context
    Mice at 14 mo of age were fed an HFD, and NMN was added to their drinking water at a dose of 400 mg/kg for 7 mo.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In aging mice fed a high-fat diet, NMN reduced renal damage.

    In plain wordsIn mice fed a high-fat diet, NMN reduced kidney damage.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseRenal damage
    Study

    mousen: not reported in source

    Aging mice fed a high-fat diet
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    400 mg/kg · drinking water · 7 moAs given in this study (mouse).

    Source sentences

    Summary
    NMN inhibited HFD-induced obesity, promoted physical activity, improved glucose and lipid metabolism, improved skeletal muscle function and renal damage, as well as mitigated the senescence and inflammaging as demonstrated by p16, interleukin 1β, and tumor necrosis factor α levels.
    1 context sentence
    Summary · context
    Mice at 14 mo of age were fed an HFD, and NMN was added to their drinking water at a dose of 400 mg/kg for 7 mo.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In high-fat-diet-fed mice, NMN may protect tissues by inhibiting excessive autophagy.

    In plain wordsIn mice fed a high-fat diet, NMN may protect tissues by reducing excessive autophagy.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseExcessive autophagy
    Study

    mousen: not reported in source

    Aging mice fed a high-fat diet
    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    400 mg/kg · drinking water · 7 moAs given in this study (mouse).

    Source sentences

    Summary
    We detected changes in autophagy levels in various tissue organs, and NMN may play a protective role by inhibiting excessive autophagy induced by HFD.
    1 context sentence
    Summary · context
    Mice at 14 mo of age were fed an HFD, and NMN was added to their drinking water at a dose of 400 mg/kg for 7 mo.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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