Skip to content

Study · Animal study (in vivo) · mouse · 2024

13 results

Nicotinamide mononucleotide ameliorates ionizing radiation-induced spermatogenic dysfunction in mice by modulating the glycolytic pathway.

Yang W, Nong W, Liu K, Lei X, Chen X, Jiang P, Tang J, Hu C, Hu Z, Li M

Acta biochimica et biophysica Sinica1 Oct 2024Cited by 6 (Europe PMC)

PMID39420833 (opens in a new tab)PMCIDPMC11877142 (opens in a new tab)DOI10.3724/abbs.2024167 (opens in a new tab)PepBankPUB-39420833
Read at sourcePubMedAsk about this study
Jump to 13 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study13

13 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In irradiated mice, NMN restored sperm quantity.

    In plain wordsIn irradiated mice, NMN restored sperm quantity compared with irradiation alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseSperm quantity
    Study

    mousen: not reported in source

    Ionizing radiation-induced testicular injury
    Comparator
    Irradiated mice without NMN
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    500 mg/kg · oralAs given in this study (mouse).

    Source sentences

    Summary
    The sperm quantity, motility, and testicular volume are reduced in the 5 Gy group but are restored by NMN supplementation.
    2 context sentences
    Summary · context
    To assess the effects of NMN, single whole-body γ-ray irradiation is used to induce testicular injury and spermatogenic dysfunction in adult male mice.
    Summary · context
    NMN is orally administered at 500 mg/kg before and after IR exposure.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In irradiated mice, NMN restored sperm motility.

    In plain wordsIn irradiated mice, NMN restored sperm movement compared with irradiation alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseSperm motility
    Study

    mousen: not reported in source

    Ionizing radiation-induced testicular injury
    Comparator
    Irradiated mice without NMN
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    500 mg/kg · oralAs given in this study (mouse).

    Source sentences

    Summary
    The sperm quantity, motility, and testicular volume are reduced in the 5 Gy group but are restored by NMN supplementation.
    2 context sentences
    Summary · context
    To assess the effects of NMN, single whole-body γ-ray irradiation is used to induce testicular injury and spermatogenic dysfunction in adult male mice.
    Summary · context
    NMN is orally administered at 500 mg/kg before and after IR exposure.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In irradiated mice, NMN restored testicular volume.

    In plain wordsIn irradiated mice, NMN restored testicular volume compared with irradiation alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseTesticular volume
    Study

    mousen: not reported in source

    Ionizing radiation-induced testicular injury
    Comparator
    Irradiated mice without NMN
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    500 mg/kg · oralAs given in this study (mouse).

    Source sentences

    Summary
    The sperm quantity, motility, and testicular volume are reduced in the 5 Gy group but are restored by NMN supplementation.
    2 context sentences
    Summary · context
    To assess the effects of NMN, single whole-body γ-ray irradiation is used to induce testicular injury and spermatogenic dysfunction in adult male mice.
    Summary · context
    NMN is orally administered at 500 mg/kg before and after IR exposure.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In irradiated mice, NMN reduced Bax expression.

    In plain wordsIn irradiated mice, NMN reduced Bax expression compared with irradiation alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseBax expression
    Study

    mousen: not reported in source

    Ionizing radiation-induced testicular injury
    Comparator
    Irradiated mice without NMN
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    500 mg/kg · oralAs given in this study (mouse).

    Source sentences

    Summary
    NMN intervention downregulates the expressions of proapoptotic genes ( Bax and Caspase-3) and upregulates the expression of an antiapoptotic gene ( Bcl- 2).
    2 context sentences
    Summary · context
    To assess the effects of NMN, single whole-body γ-ray irradiation is used to induce testicular injury and spermatogenic dysfunction in adult male mice.
    Summary · context
    NMN is orally administered at 500 mg/kg before and after IR exposure.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In irradiated mice, NMN reduced Caspase-3 expression.

    In plain wordsIn irradiated mice, NMN reduced Caspase-3 expression compared with irradiation alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseCaspase-3 expression
    Study

    mousen: not reported in source

    Ionizing radiation-induced testicular injury
    Comparator
    Irradiated mice without NMN
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    500 mg/kg · oralAs given in this study (mouse).

    Source sentences

    Summary
    NMN intervention downregulates the expressions of proapoptotic genes ( Bax and Caspase-3) and upregulates the expression of an antiapoptotic gene ( Bcl- 2).
    2 context sentences
    Summary · context
    To assess the effects of NMN, single whole-body γ-ray irradiation is used to induce testicular injury and spermatogenic dysfunction in adult male mice.
    Summary · context
    NMN is orally administered at 500 mg/kg before and after IR exposure.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In irradiated mice, NMN increased Bcl-2 expression.

    In plain wordsIn irradiated mice, NMN increased Bcl-2 expression compared with irradiation alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseBcl-2 expression
    Study

    mousen: not reported in source

    Ionizing radiation-induced testicular injury
    Comparator
    Irradiated mice without NMN
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    500 mg/kg · oralAs given in this study (mouse).

    Source sentences

    Summary
    NMN intervention downregulates the expressions of proapoptotic genes ( Bax and Caspase-3) and upregulates the expression of an antiapoptotic gene ( Bcl- 2).
    2 context sentences
    Summary · context
    To assess the effects of NMN, single whole-body γ-ray irradiation is used to induce testicular injury and spermatogenic dysfunction in adult male mice.
    Summary · context
    NMN is orally administered at 500 mg/kg before and after IR exposure.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In irradiated mice, NMN increased WT-1 expression.

    In plain wordsIn irradiated mice, NMN increased WT-1 expression compared with irradiation alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseWT-1 expression
    Study

    mousen: not reported in source

    Ionizing radiation-induced testicular injury
    Comparator
    Irradiated mice without NMN
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    500 mg/kg · oralAs given in this study (mouse).

    Source sentences

    Summary
    Sertoli cells marker genes ( WT-1, GATA-4, SOX9, and vimentin) and glycolysis rate-limiting enzyme-encoding genes ( HK2, PKM2, and LDHA) are significantly upregulated.
    2 context sentences
    Summary · context
    To assess the effects of NMN, single whole-body γ-ray irradiation is used to induce testicular injury and spermatogenic dysfunction in adult male mice.
    Summary · context
    NMN is orally administered at 500 mg/kg before and after IR exposure.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In irradiated mice, NMN increased GATA-4 expression.

    In plain wordsIn irradiated mice, NMN increased GATA-4 expression compared with irradiation alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseGATA-4 expression
    Study

    mousen: not reported in source

    Ionizing radiation-induced testicular injury
    Comparator
    Irradiated mice without NMN
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    500 mg/kg · oralAs given in this study (mouse).

    Source sentences

    Summary
    Sertoli cells marker genes ( WT-1, GATA-4, SOX9, and vimentin) and glycolysis rate-limiting enzyme-encoding genes ( HK2, PKM2, and LDHA) are significantly upregulated.
    2 context sentences
    Summary · context
    To assess the effects of NMN, single whole-body γ-ray irradiation is used to induce testicular injury and spermatogenic dysfunction in adult male mice.
    Summary · context
    NMN is orally administered at 500 mg/kg before and after IR exposure.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In irradiated mice, NMN increased SOX9 expression.

    In plain wordsIn irradiated mice, NMN increased SOX9 expression compared with irradiation alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseSOX9 expression
    Study

    mousen: not reported in source

    Ionizing radiation-induced testicular injury
    Comparator
    Irradiated mice without NMN
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    500 mg/kg · oralAs given in this study (mouse).

    Source sentences

    Summary
    Sertoli cells marker genes ( WT-1, GATA-4, SOX9, and vimentin) and glycolysis rate-limiting enzyme-encoding genes ( HK2, PKM2, and LDHA) are significantly upregulated.
    2 context sentences
    Summary · context
    To assess the effects of NMN, single whole-body γ-ray irradiation is used to induce testicular injury and spermatogenic dysfunction in adult male mice.
    Summary · context
    NMN is orally administered at 500 mg/kg before and after IR exposure.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In irradiated mice, NMN increased vimentin expression.

    In plain wordsIn irradiated mice, NMN increased vimentin expression compared with irradiation alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseVimentin expression
    Study

    mousen: not reported in source

    Ionizing radiation-induced testicular injury
    Comparator
    Irradiated mice without NMN
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    500 mg/kg · oralAs given in this study (mouse).

    Source sentences

    Summary
    Sertoli cells marker genes ( WT-1, GATA-4, SOX9, and vimentin) and glycolysis rate-limiting enzyme-encoding genes ( HK2, PKM2, and LDHA) are significantly upregulated.
    2 context sentences
    Summary · context
    To assess the effects of NMN, single whole-body γ-ray irradiation is used to induce testicular injury and spermatogenic dysfunction in adult male mice.
    Summary · context
    NMN is orally administered at 500 mg/kg before and after IR exposure.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In irradiated mice, NMN increased HK2 expression.

    In plain wordsIn irradiated mice, NMN increased HK2 expression compared with irradiation alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseHK2 expression
    Study

    mousen: not reported in source

    Ionizing radiation-induced testicular injury
    Comparator
    Irradiated mice without NMN
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    500 mg/kg · oralAs given in this study (mouse).

    Source sentences

    Summary
    Sertoli cells marker genes ( WT-1, GATA-4, SOX9, and vimentin) and glycolysis rate-limiting enzyme-encoding genes ( HK2, PKM2, and LDHA) are significantly upregulated.
    2 context sentences
    Summary · context
    To assess the effects of NMN, single whole-body γ-ray irradiation is used to induce testicular injury and spermatogenic dysfunction in adult male mice.
    Summary · context
    NMN is orally administered at 500 mg/kg before and after IR exposure.
  12. 12AnimalAnimal study (in vivo)Mechanism

    In irradiated mice, NMN increased PKM2 expression.

    In plain wordsIn irradiated mice, NMN increased PKM2 expression compared with irradiation alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreasePKM2 expression
    Study

    mousen: not reported in source

    Ionizing radiation-induced testicular injury
    Comparator
    Irradiated mice without NMN
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    500 mg/kg · oralAs given in this study (mouse).

    Source sentences

    Summary
    Sertoli cells marker genes ( WT-1, GATA-4, SOX9, and vimentin) and glycolysis rate-limiting enzyme-encoding genes ( HK2, PKM2, and LDHA) are significantly upregulated.
    2 context sentences
    Summary · context
    To assess the effects of NMN, single whole-body γ-ray irradiation is used to induce testicular injury and spermatogenic dysfunction in adult male mice.
    Summary · context
    NMN is orally administered at 500 mg/kg before and after IR exposure.
  13. 13AnimalAnimal study (in vivo)Mechanism

    In irradiated mice, NMN increased LDHA expression.

    In plain wordsIn irradiated mice, NMN increased LDHA expression compared with irradiation alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseLDHA expression
    Study

    mousen: not reported in source

    Ionizing radiation-induced testicular injury
    Comparator
    Irradiated mice without NMN
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    500 mg/kg · oralAs given in this study (mouse).

    Source sentences

    Summary
    Sertoli cells marker genes ( WT-1, GATA-4, SOX9, and vimentin) and glycolysis rate-limiting enzyme-encoding genes ( HK2, PKM2, and LDHA) are significantly upregulated.
    2 context sentences
    Summary · context
    To assess the effects of NMN, single whole-body γ-ray irradiation is used to induce testicular injury and spermatogenic dysfunction in adult male mice.
    Summary · context
    NMN is orally administered at 500 mg/kg before and after IR exposure.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.