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Study · Animal study (in vivo) · rat · 2024

9 results

Nicotinamide Mononucleotide Improves Endometrial Homeostasis in a Rat Model of Polycystic Ovary Syndrome by Decreasing Insulin Resistance and Regulating the Glylytic Pathway.

Zhang W, Zhang J, Xue H, Chen X, Li M, Chen S, Li Z, Sechi LA, Wang Q, Capobianco G, Lei X

Molecular nutrition & food research17 Oct 2024Cited by 5 (Europe PMC)

PMID39420767 (opens in a new tab)DOI10.1002/mnfr.202400340 (opens in a new tab)PepBankPUB-39420767
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In PCOS rats, NMN restored regular estrous cycles compared with untreated PCOS rats.

    In plain wordsIn rats with PCOS, NMN restored regular reproductive cycles compared with untreated PCOS rats.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseEstrous cycles
    Study

    ratn: not reported in source

    Letrozole and high-fat diet PCOS model
    Comparator
    PCOS group without NMN
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Compared with the PCOS group, the regular estrous cycles are restored, the serum androgen (p<0.01) and fasting insulin levels (p<0.05) are reduced, and endometrial morphology (p<0.05) is improved in NMN-PCOS group.
    1 context sentence
    Summary · context
    Female Sprague-Dawley (SD) rats are fed letrozole and a high-fat diet (HFD) to form the PCOS model, then the model rats are treated with or without NMN.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In PCOS rats, NMN reduced serum androgen compared with untreated PCOS rats.

    In plain wordsIn rats with PCOS, NMN reduced blood androgen compared with untreated PCOS rats.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseSerum androgen
    Study

    ratn: not reported in source

    Letrozole and high-fat diet PCOS model
    Comparator
    PCOS group without NMN
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Compared with the PCOS group, the regular estrous cycles are restored, the serum androgen (p<0.01) and fasting insulin levels (p<0.05) are reduced, and endometrial morphology (p<0.05) is improved in NMN-PCOS group.
    1 context sentence
    Summary · context
    Female Sprague-Dawley (SD) rats are fed letrozole and a high-fat diet (HFD) to form the PCOS model, then the model rats are treated with or without NMN.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In PCOS rats, NMN reduced fasting insulin compared with untreated PCOS rats.

    In plain wordsIn rats with PCOS, NMN reduced fasting insulin compared with untreated PCOS rats.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseFasting insulin
    Study

    ratn: not reported in source

    Letrozole and high-fat diet PCOS model
    Comparator
    PCOS group without NMN
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Compared with the PCOS group, the regular estrous cycles are restored, the serum androgen (p<0.01) and fasting insulin levels (p<0.05) are reduced, and endometrial morphology (p<0.05) is improved in NMN-PCOS group.
    1 context sentence
    Summary · context
    Female Sprague-Dawley (SD) rats are fed letrozole and a high-fat diet (HFD) to form the PCOS model, then the model rats are treated with or without NMN.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In PCOS rats, NMN improved endometrial morphology compared with untreated PCOS rats.

    In plain wordsIn rats with PCOS, NMN improved uterine lining structure compared with untreated PCOS rats.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseEndometrial morphology
    Study

    ratn: not reported in source

    Letrozole and high-fat diet PCOS model
    Comparator
    PCOS group without NMN
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Compared with the PCOS group, the regular estrous cycles are restored, the serum androgen (p<0.01) and fasting insulin levels (p<0.05) are reduced, and endometrial morphology (p<0.05) is improved in NMN-PCOS group.
    1 context sentence
    Summary · context
    Female Sprague-Dawley (SD) rats are fed letrozole and a high-fat diet (HFD) to form the PCOS model, then the model rats are treated with or without NMN.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In PCOS rats, NMN inhibited endometrial cell apoptosis.

    In plain wordsIn rats with PCOS, NMN reduced uterine lining cell death compared with untreated PCOS rats.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseEndometrial cell apoptosis
    Study

    ratn: not reported in source

    Letrozole and high-fat diet PCOS model
    Comparator
    PCOS group without NMN
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, NMN inhibits endometrial cell apoptosis, improves endometrial decidualization transition, reduces IR, restores the expression of glycolysis rate-limiting enzymes, and activates the PI3K/AKT pathway in the uterus.
    1 context sentence
    Summary · context
    Female Sprague-Dawley (SD) rats are fed letrozole and a high-fat diet (HFD) to form the PCOS model, then the model rats are treated with or without NMN.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In PCOS rats, NMN improved endometrial decidualization transition.

    In plain wordsIn rats with PCOS, NMN improved uterine lining maturation compared with untreated PCOS rats.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseEndometrial decidualization transition
    Study

    ratn: not reported in source

    Letrozole and high-fat diet PCOS model
    Comparator
    PCOS group without NMN
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, NMN inhibits endometrial cell apoptosis, improves endometrial decidualization transition, reduces IR, restores the expression of glycolysis rate-limiting enzymes, and activates the PI3K/AKT pathway in the uterus.
    1 context sentence
    Summary · context
    Female Sprague-Dawley (SD) rats are fed letrozole and a high-fat diet (HFD) to form the PCOS model, then the model rats are treated with or without NMN.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In PCOS rats, NMN reduced uterine insulin resistance.

    In plain wordsIn rats with PCOS, NMN reduced uterine insulin resistance compared with untreated PCOS rats.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseInsulin resistance
    Study

    ratn: not reported in source

    Letrozole and high-fat diet PCOS model
    Comparator
    PCOS group without NMN
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, NMN inhibits endometrial cell apoptosis, improves endometrial decidualization transition, reduces IR, restores the expression of glycolysis rate-limiting enzymes, and activates the PI3K/AKT pathway in the uterus.
    1 context sentence
    Summary · context
    Female Sprague-Dawley (SD) rats are fed letrozole and a high-fat diet (HFD) to form the PCOS model, then the model rats are treated with or without NMN.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In PCOS rats, NMN restored uterine glycolysis rate-limiting enzyme expression.

    In plain wordsIn rats with PCOS, NMN restored uterine glycolysis enzyme expression compared with untreated PCOS rats.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Direction not reportedGlycolysis enzyme expression
    Study

    ratn: not reported in source

    Letrozole and high-fat diet PCOS model
    Comparator
    PCOS group without NMN
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, NMN inhibits endometrial cell apoptosis, improves endometrial decidualization transition, reduces IR, restores the expression of glycolysis rate-limiting enzymes, and activates the PI3K/AKT pathway in the uterus.
    1 context sentence
    Summary · context
    Female Sprague-Dawley (SD) rats are fed letrozole and a high-fat diet (HFD) to form the PCOS model, then the model rats are treated with or without NMN.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In PCOS rats, NMN activated the uterine PI3K/AKT pathway.

    In plain wordsIn rats with PCOS, NMN increased uterine PI3K/AKT pathway activity compared with untreated PCOS rats.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreasePI3K/AKT activation
    Study

    ratn: not reported in source

    Letrozole and high-fat diet PCOS model
    Comparator
    PCOS group without NMN
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, NMN inhibits endometrial cell apoptosis, improves endometrial decidualization transition, reduces IR, restores the expression of glycolysis rate-limiting enzymes, and activates the PI3K/AKT pathway in the uterus.
    1 context sentence
    Summary · context
    Female Sprague-Dawley (SD) rats are fed letrozole and a high-fat diet (HFD) to form the PCOS model, then the model rats are treated with or without NMN.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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