Nicotinamide mononucleotide supplementation rescues mitochondrial and energy metabolism functions and ameliorates inflammatory states in the ovaries of aging mice.

Liang J, Huang F, Hao X, Zhang P, Chen R

MedComm30 Sept 2024Cited by 28 (Europe PMC)

PMID39355508PMCIDPMC11442848DOI10.1002/mco2.727PepBankPUB-39355508

Summary

Noninvasive pharmacological strategies like nicotinamide mononucleotide (NMN) supplementation can effectively address age-related ovarian infertility by maintaining or enhancing oocyte quality and quantity. This study revealed that ovarian nicotinamide adenine dinucleotide levels decline with age, but NMN administration significantly restores these levels, preventing ovarian atrophy and enhancing the quality and quantity of ovulated oocytes. Improvements in serum hormone secretion and antioxidant factors, along with decreased expression of proinflammatory factors, were observed. Additionally, a significant increase in the number of ovarian follicles in aging individuals was noted. Scanning electron microscopy data indicated that NMN significantly alters the density and morphology of lipid droplets and mitochondria in granulosa cells, suggesting potential targets and mechanisms. Transcriptomic analysis and validation experiments collectively suggested that the beneficial effects of NMN on aging ovaries are mediated through enhanced mitochondrial function, improved energy metabolism, and reduced inflammation levels. Our results suggest that NMN supplementation could improve the health status of aging ovaries and enhance ovarian reserve, offering new insights into addressing fertility challenges in older women through assisted reproductive technology.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In aging mice, NMN restored ovarian NAD levels.
In plain wordsIn mice, NMN restored ovarian NAD levels during aging.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseOvarian NAD levels
Study
mousen: not reported in source
aging ovaries
Outcome group
Mitochondrial function · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
This study revealed that ovarian nicotinamide adenine dinucleotide levels decline with age, but NMN administration significantly restores these levels, preventing ovarian atrophy and enhancing the quality and quantity of ovulated oocytes.
Show in the study text Report a problemFND-3935550801
02AnimalAnimal study (in vivo)Mechanism
In aging mice, NMN prevented ovarian atrophy.
In plain wordsIn mice, NMN prevented ovarian shrinkage during aging.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseOvarian atrophy
Study
mousen: not reported in source
aging ovaries
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
This study revealed that ovarian nicotinamide adenine dinucleotide levels decline with age, but NMN administration significantly restores these levels, preventing ovarian atrophy and enhancing the quality and quantity of ovulated oocytes.
Show in the study text Report a problemFND-3935550802
03AnimalAnimal study (in vivo)Mechanism
In aging mice, NMN enhanced ovulated oocyte quality.
In plain wordsIn mice, NMN improved the quality of released eggs during aging.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
Direction not reportedOvulated oocyte quality
Study
mousen: not reported in source
aging ovaries
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
This study revealed that ovarian nicotinamide adenine dinucleotide levels decline with age, but NMN administration significantly restores these levels, preventing ovarian atrophy and enhancing the quality and quantity of ovulated oocytes.
Show in the study text Report a problemFND-3935550803
04AnimalAnimal study (in vivo)Mechanism
In aging mice, NMN increased ovulated oocyte quantity.
In plain wordsIn mice, NMN increased the number of released eggs during aging.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseOvulated oocyte quantity
Study
mousen: not reported in source
aging ovaries
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
This study revealed that ovarian nicotinamide adenine dinucleotide levels decline with age, but NMN administration significantly restores these levels, preventing ovarian atrophy and enhancing the quality and quantity of ovulated oocytes.
Show in the study text Report a problemFND-3935550804
05AnimalAnimal study (in vivo)Mechanism
In aging mice, NMN improved serum hormone secretion.
In plain wordsIn mice, NMN improved blood hormone secretion during ovarian aging.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
Direction not reportedSerum hormone secretion
Study
mousen: not reported in source
aging ovaries
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Improvements in serum hormone secretion and antioxidant factors, along with decreased expression of proinflammatory factors, were observed.
1 context sentence(design, population, supporting numbers)
Summary · context
This study revealed that ovarian nicotinamide adenine dinucleotide levels decline with age, but NMN administration significantly restores these levels, preventing ovarian atrophy and enhancing the quality and quantity of ovulated oocytes.
Show in the study text Report a problemFND-3935550805
06AnimalAnimal study (in vivo)Mechanism
In aging mice, NMN improved antioxidant factors.
In plain wordsIn mice, NMN improved antioxidant factors during ovarian aging.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
Direction not reportedAntioxidant factors
Study
mousen: not reported in source
aging ovaries
Outcome group
Oxidative stress · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Improvements in serum hormone secretion and antioxidant factors, along with decreased expression of proinflammatory factors, were observed.
1 context sentence(design, population, supporting numbers)
Summary · context
This study revealed that ovarian nicotinamide adenine dinucleotide levels decline with age, but NMN administration significantly restores these levels, preventing ovarian atrophy and enhancing the quality and quantity of ovulated oocytes.
Show in the study text Report a problemFND-3935550806
07AnimalAnimal study (in vivo)Mechanism
In aging mice, NMN decreased proinflammatory factor expression.
In plain wordsIn mice, NMN reduced proinflammatory factor expression during ovarian aging.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseProinflammatory factor expression
Study
mousen: not reported in source
aging ovaries
Outcome group
Inflammation markers · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Improvements in serum hormone secretion and antioxidant factors, along with decreased expression of proinflammatory factors, were observed.
1 context sentence(design, population, supporting numbers)
Summary · context
This study revealed that ovarian nicotinamide adenine dinucleotide levels decline with age, but NMN administration significantly restores these levels, preventing ovarian atrophy and enhancing the quality and quantity of ovulated oocytes.
Show in the study text Report a problemFND-3935550807
08AnimalAnimal study (in vivo)Mechanism
In aging mice, NMN increased ovarian follicle numbers.
In plain wordsIn mice, NMN increased ovarian follicle numbers during aging.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseOvarian follicle number
Study
mousen: not reported in source
aging ovaries
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Additionally, a significant increase in the number of ovarian follicles in aging individuals was noted.
1 context sentence(design, population, supporting numbers)
Summary · context
This study revealed that ovarian nicotinamide adenine dinucleotide levels decline with age, but NMN administration significantly restores these levels, preventing ovarian atrophy and enhancing the quality and quantity of ovulated oocytes.
Show in the study text Report a problemFND-3935550808
09AnimalAnimal study (in vivo)Mechanism
In aging mice, experiments suggested that NMN enhanced ovarian mitochondrial function.
In plain wordsIn mice, experiments suggested that NMN improved ovarian mitochondrial function.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
Direction not reportedMitochondrial function
Study
mousen: not reported in source
aging ovaries
Outcome group
Mitochondrial function · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Transcriptomic analysis and validation experiments collectively suggested that the beneficial effects of NMN on aging ovaries are mediated through enhanced mitochondrial function, improved energy metabolism, and reduced inflammation levels.
Show in the study text Report a problemFND-3935550809
10AnimalAnimal study (in vivo)Mechanism
In aging mice, experiments suggested that NMN improved ovarian energy metabolism.
In plain wordsIn mice, experiments suggested that NMN improved ovarian energy metabolism.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
Direction not reportedEnergy metabolism
Study
mousen: not reported in source
aging ovaries
Outcome group
Mitochondrial function · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Transcriptomic analysis and validation experiments collectively suggested that the beneficial effects of NMN on aging ovaries are mediated through enhanced mitochondrial function, improved energy metabolism, and reduced inflammation levels.
Show in the study text Report a problemFND-3935550810
11AnimalAnimal study (in vivo)Mechanism
In aging mice, experiments suggested that NMN reduced ovarian inflammation.
In plain wordsIn mice, experiments suggested that NMN reduced ovarian inflammation.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseOvarian inflammation
Study
mousen: not reported in source
aging ovaries
Outcome group
Inflammation markers · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Transcriptomic analysis and validation experiments collectively suggested that the beneficial effects of NMN on aging ovaries are mediated through enhanced mitochondrial function, improved energy metabolism, and reduced inflammation levels.
Show in the study text Report a problemFND-3935550811

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

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