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Study · Animal study (in vivo) · mouse · 2024

6 results

Quantitative proteomics analysis reveals the protective role of S14G-humanin in septic acute kidney injury using 4D-label-free and PRM Approaches.

Shi Q, Xiao Z, Cai W, Chen Y, Liang H, Ye Z, Li Z, Liang X

Biochemical and biophysical research communications12 Sept 2024Cited by 2 (Europe PMC)

PMID39332154 (opens in a new tab)DOI10.1016/j.bbrc.2024.150630 (opens in a new tab)PepBankPUB-39332154
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced septic acute kidney injury, S14G-humanin treatment improved renal function.

    In plain wordsIn mice with septic kidney injury, S14G-humanin treatment improved kidney function.

    Peptide
    Humanin
    Outcome
    IncreaseRenal function
    Study

    mousen: not reported in source

    LPS-induced septic acute kidney injury
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG treatment improved renal function, reduced tubular injury, and decreased pro-inflammatory cytokines and oxidative stress markers.
    1 context sentence
    Summary · context
    An S-AKI model was created in male C57BL/6 mice using lipopolysaccharide (LPS) injection, followed by HNG administration.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced septic acute kidney injury, S14G-humanin treatment reduced tubular injury.

    In plain wordsIn mice with septic kidney injury, S14G-humanin treatment reduced damage to the kidney tubules.

    Peptide
    Humanin
    Outcome
    DecreaseTubular injury
    Study

    mousen: not reported in source

    LPS-induced septic acute kidney injury
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG treatment improved renal function, reduced tubular injury, and decreased pro-inflammatory cytokines and oxidative stress markers.
    1 context sentence
    Summary · context
    An S-AKI model was created in male C57BL/6 mice using lipopolysaccharide (LPS) injection, followed by HNG administration.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced septic acute kidney injury, S14G-humanin treatment decreased pro-inflammatory cytokines.

    In plain wordsIn mice with septic kidney injury, S14G-humanin treatment lowered inflammation signals in the kidney.

    Peptide
    Humanin
    Outcome
    DecreasePro-inflammatory cytokines
    Study

    mousen: not reported in source

    LPS-induced septic acute kidney injury
    Outcome group
    Inflammation markers · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG treatment improved renal function, reduced tubular injury, and decreased pro-inflammatory cytokines and oxidative stress markers.
    1 context sentence
    Summary · context
    An S-AKI model was created in male C57BL/6 mice using lipopolysaccharide (LPS) injection, followed by HNG administration.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced septic acute kidney injury, S14G-humanin treatment decreased oxidative stress markers.

    In plain wordsIn mice with septic kidney injury, S14G-humanin treatment lowered oxidative stress markers in the kidney.

    Peptide
    Humanin
    Outcome
    DecreaseOxidative stress markers
    Study

    mousen: not reported in source

    LPS-induced septic acute kidney injury
    Outcome group
    Inflammation markers · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG treatment improved renal function, reduced tubular injury, and decreased pro-inflammatory cytokines and oxidative stress markers.
    1 context sentence
    Summary · context
    An S-AKI model was created in male C57BL/6 mice using lipopolysaccharide (LPS) injection, followed by HNG administration.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice with LPS-induced septic acute kidney injury, S14G-humanin altered the expression of 132 proteins, and 18 were selected for PRM validation.

    In plain wordsIn mice with septic kidney injury, S14G-humanin changed the levels of 132 kidney proteins.

    Peptide
    Humanin
    Outcome
    MixedKidney protein expression by proteomics
    Study

    mousen: not reported in source

    LPS-induced septic acute kidney injury
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG altered the expression of 132 proteins, with 18 selected for PRM validation.
    1 context sentence
    Summary · context
    An S-AKI model was created in male C57BL/6 mice using lipopolysaccharide (LPS) injection, followed by HNG administration.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mice with LPS-induced septic acute kidney injury, ten of the 18 proteins selected for PRM validation were linked to pathways including fatty acid degradation and PPAR signaling.

    In plain wordsIn mice with septic kidney injury, proteins changed by S14G-humanin were linked to fatty acid breakdown and PPAR signalling.

    Peptide
    Humanin
    Outcome
    Not applicablePathways linked to altered proteins
    Study

    mousen: not reported in source

    LPS-induced septic acute kidney injury
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Ten of these proteins were linked to key pathways, including fatty acid degradation and PPAR signaling.
    1 context sentence
    Summary · context
    An S-AKI model was created in male C57BL/6 mice using lipopolysaccharide (LPS) injection, followed by HNG administration.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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