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Study · Animal study (in vivo) · rat · 2024

6 results

Chronic Nasal Administration of Kisspeptin-54 Regulates Mood-Related Disorders Via Amygdaloid GABA in Hemi-Parkinsonian Rats

Sinen O, Gemici Sinen A, Derin N, Aslan MA

Balkan medical journal25 Sept 2024Cited by 3 (Europe PMC)

PMID39319821 (opens in a new tab)PMCIDPMC11589217 (opens in a new tab)DOI10.4274/balkanmedj.galenos.2024.2024-7-46 (opens in a new tab)PepBankPUB-39319821
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In 6-OHDA hemiparkinsonian rats, nasal KP-54 significantly reduced depression-like behavior induced by 6-OHDA.

    In plain wordsIn rats with a Parkinson-like lesion, nasal kisspeptin‑54 reduced depression-like behavior.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    DecreaseDepression-like behavior (sucrose preference test)
    Study

    ratn: not reported in source

    6-OHDA hemiparkinsonian Sprague Dawley rats
    Comparator
    Vehicle (artificial cerebrospinal fluid)
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    3 nmol/kg · nasal (topical to the rhinarium) · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    The nasal delivery of KP-54 significantly reduced depressionand anxiety-like behaviors that were induced by 6-OHDA, as indicated by the results of the SPT, OFT, and EPMT.
    2 context sentences
    Summary · context
    This study included adult Sprague Dawley male rats who were administered either a vehicle (artificial cerebrospinal fluid) or 6-hydroxydopamine (6-OHDA) unilaterally into the medial forebrain bundle.
    Summary · context
    The vehicle, or KP-54 (3 nmol/kg, applied topically to the rhinarium), was administered daily for a seven-day period.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In 6-OHDA hemiparkinsonian rats, nasal KP-54 significantly reduced anxiety-like behavior induced by 6-OHDA.

    In plain wordsIn rats with a Parkinson-like lesion, nasal kisspeptin‑54 reduced anxiety-like behavior.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    DecreaseAnxiety-like behavior (open field and elevated plus maze tests)
    Study

    ratn: not reported in source

    6-OHDA hemiparkinsonian Sprague Dawley rats
    Comparator
    Vehicle (artificial cerebrospinal fluid)
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    3 nmol/kg · nasal (topical to the rhinarium) · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    The nasal delivery of KP-54 significantly reduced depressionand anxiety-like behaviors that were induced by 6-OHDA, as indicated by the results of the SPT, OFT, and EPMT.
    2 context sentences
    Summary · context
    This study included adult Sprague Dawley male rats who were administered either a vehicle (artificial cerebrospinal fluid) or 6-hydroxydopamine (6-OHDA) unilaterally into the medial forebrain bundle.
    Summary · context
    The vehicle, or KP-54 (3 nmol/kg, applied topically to the rhinarium), was administered daily for a seven-day period.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In 6-OHDA hemiparkinsonian rats, nasal KP-54 mitigated 6-OHDA-induced motor deficits.

    In plain wordsIn rats with a Parkinson-like lesion, nasal kisspeptin‑54 reduced the movement problems caused by the lesion.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    DecreaseMotor deficits
    Study

    ratn: not reported in source

    6-OHDA hemiparkinsonian Sprague Dawley rats
    Comparator
    Vehicle (artificial cerebrospinal fluid)
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    3 nmol/kg · nasal (topical to the rhinarium) · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    Moreover, it was observed that nasal KP-54 effectively mitigated 6-OHDA-induced motor deficits and the loss of nigral dopaminergic neurons.
    2 context sentences
    Summary · context
    This study included adult Sprague Dawley male rats who were administered either a vehicle (artificial cerebrospinal fluid) or 6-hydroxydopamine (6-OHDA) unilaterally into the medial forebrain bundle.
    Summary · context
    The vehicle, or KP-54 (3 nmol/kg, applied topically to the rhinarium), was administered daily for a seven-day period.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In 6-OHDA hemiparkinsonian rats, nasal KP-54 mitigated the 6-OHDA-induced loss of nigral dopaminergic neurons.

    In plain wordsIn rats with a Parkinson-like lesion, nasal kisspeptin‑54 reduced the loss of dopamine-producing neurons.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    DecreaseLoss of nigral dopaminergic neurons
    Study

    ratn: not reported in source

    6-OHDA hemiparkinsonian Sprague Dawley rats
    Comparator
    Vehicle (artificial cerebrospinal fluid)
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    3 nmol/kg · nasal (topical to the rhinarium) · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    Moreover, it was observed that nasal KP-54 effectively mitigated 6-OHDA-induced motor deficits and the loss of nigral dopaminergic neurons.
    2 context sentences
    Summary · context
    This study included adult Sprague Dawley male rats who were administered either a vehicle (artificial cerebrospinal fluid) or 6-hydroxydopamine (6-OHDA) unilaterally into the medial forebrain bundle.
    Summary · context
    The vehicle, or KP-54 (3 nmol/kg, applied topically to the rhinarium), was administered daily for a seven-day period.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In 6-OHDA hemiparkinsonian rats, the abstract states that nasal KP-54 augmented the 6-OHDA-induced decline in amygdala GABA levels.

    In plain wordsIn rats with a Parkinson-like lesion, nasal kisspeptin‑54 changed the lesion-related drop in amygdala GABA levels.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    MixedAmygdala GABA concentration
    Study

    ratn: not reported in source

    6-OHDA hemiparkinsonian Sprague Dawley rats
    Comparator
    Vehicle (artificial cerebrospinal fluid)
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    3 nmol/kg · nasal (topical to the rhinarium) · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    The nasal administration of KP-54 augmented the decline in GABA levels in the amygdala induced by 6-OHDA.
    2 context sentences
    Summary · context
    This study included adult Sprague Dawley male rats who were administered either a vehicle (artificial cerebrospinal fluid) or 6-hydroxydopamine (6-OHDA) unilaterally into the medial forebrain bundle.
    Summary · context
    The vehicle, or KP-54 (3 nmol/kg, applied topically to the rhinarium), was administered daily for a seven-day period.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In 6-OHDA hemiparkinsonian rats given KP-54, amygdala GABA concentrations correlated with behavioral parameters.

    In plain wordsIn rats with a Parkinson-like lesion, amygdala GABA levels went with behavior test results.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    Not applicableCorrelation of GABA concentration with behavior
    Study

    ratn: not reported in source

    6-OHDA hemiparkinsonian Sprague Dawley rats
    Comparator
    Vehicle (artificial cerebrospinal fluid)
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    3 nmol/kg · nasal (topical to the rhinarium) · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    Furthermore, effective correlations were established between GABA concentrations and behavioral parameters.
    2 context sentences
    Summary · context
    This study included adult Sprague Dawley male rats who were administered either a vehicle (artificial cerebrospinal fluid) or 6-hydroxydopamine (6-OHDA) unilaterally into the medial forebrain bundle.
    Summary · context
    The vehicle, or KP-54 (3 nmol/kg, applied topically to the rhinarium), was administered daily for a seven-day period.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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