Skip to content

Study · Not a test of the peptide alone · 2024

5 results

Enhanced skin benefits of EGCG loaded in nonapeptide-1-conjugated mesoporous silica nanoparticles to reverse skin photoaging.

Huang ZJ, Zhou XH, Wen WQ, Huang ZT, Xuan J, Gui P, Peng W, Wang G

International journal of pharmaceutics12 Sept 2024Cited by 6 (Europe PMC)

PMID39260749 (opens in a new tab)DOI10.1016/j.ijpharm.2024.124690 (opens in a new tab)PepBankPUB-39260749
Publisher pagePubMedAsk about this study
Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Nonapeptide-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Nonapeptide-1.

  1. 01AnimalNot a test of Nonapeptide-1 aloneOther designActivity measurement

    In combined laboratory and animal models, the EGCG-loaded nonapeptide‑1 nanoparticle formulation retained antioxidant properties.

    In plain wordsIn laboratory and animal models, the EGCG-loaded nonapeptide‑1 nanoparticle formulation retained antioxidant properties.

    Peptide
    Nonapeptide-1
    Outcome
    Not applicableAntioxidant properties
    Study

    n: not reported in source

    in vitro and in vivo skin photoaging models
    Outcome group
    Skin and hair · Skin and wound

    Source sentences

    Summary
    In vitro and in vivo results confirmed that the EGCG-loaded MSNs retained antioxidant properties, effectively scavenged the melanin and significantly reduced the deoxyribonucleic acid (DNA) damage in skin cells exposed to UV irradiation.
    1 context sentence
    Summary · context
    This study, to improve the stability and bioavailability of EGCG for reversing skin photo-aging, nonapeptide-1-conjugated mesoporous silica nanoparticles (EGCG@NP-MSN) were fabricated to load EGCG.

    In this study, Nonapeptide-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Nonapeptide-1.

  2. 02AnimalNot a test of Nonapeptide-1 aloneOther designEfficacy outcome

    In combined laboratory and animal models, the EGCG-loaded nonapeptide‑1 nanoparticle formulation effectively scavenged melanin.

    In plain wordsIn laboratory and animal models, the EGCG-loaded nonapeptide‑1 nanoparticle formulation scavenged melanin.

    Peptide
    Nonapeptide-1
    Outcome
    DecreaseMelanin scavenging
    Study

    n: not reported in source

    in vitro and in vivo skin photoaging models
    Outcome group
    Skin and hair · Skin and wound

    Source sentences

    Summary
    In vitro and in vivo results confirmed that the EGCG-loaded MSNs retained antioxidant properties, effectively scavenged the melanin and significantly reduced the deoxyribonucleic acid (DNA) damage in skin cells exposed to UV irradiation.
    1 context sentence
    Summary · context
    This study, to improve the stability and bioavailability of EGCG for reversing skin photo-aging, nonapeptide-1-conjugated mesoporous silica nanoparticles (EGCG@NP-MSN) were fabricated to load EGCG.

    In this study, Nonapeptide-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Nonapeptide-1.

  3. 03AnimalNot a test of Nonapeptide-1 aloneOther designActivity measurement

    In photoaging models, the EGCG-loaded nonapeptide‑1 nanoparticle formulation had a melanin inhibition rate 5.22 times that of free EGCG.

    In plain wordsIn laboratory and animal models, the EGCG-loaded nonapeptide‑1 formulation had a melanin inhibition rate 5.22 times that of free EGCG.

    Peptide
    Nonapeptide-1
    Outcome
    IncreaseMelanin inhibition rate
    Study

    n: not reported in source

    in vitro and in vivo skin photoaging models
    Comparator
    Free EGCG
    Outcome group
    Skin and hair · Skin and wound

    Measurements

    Relative melanin inhibition rate
    5.22 fold
    versus free EGCG

    Source sentences

    Summary
    The melanin inhibition rate is 5.22 times and the tyrosinase inhibition rate is 1.57 times that of free EGCG.
    1 context sentence
    Summary · context
    This study, to improve the stability and bioavailability of EGCG for reversing skin photo-aging, nonapeptide-1-conjugated mesoporous silica nanoparticles (EGCG@NP-MSN) were fabricated to load EGCG.

    In this study, Nonapeptide-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Nonapeptide-1.

  4. 04AnimalNot a test of Nonapeptide-1 aloneOther designActivity measurement

    In photoaging models, the EGCG-loaded nonapeptide‑1 nanoparticle formulation had a tyrosinase inhibition rate 1.57 times that of free EGCG.

    In plain wordsIn laboratory and animal models, the EGCG-loaded nonapeptide‑1 formulation had a tyrosinase inhibition rate 1.57 times that of free EGCG.

    Peptide
    Nonapeptide-1
    Outcome
    IncreaseTyrosinase inhibition rate
    Study

    n: not reported in source

    in vitro and in vivo skin photoaging models
    Comparator
    Free EGCG
    Outcome group
    Skin and hair · Skin and wound

    Measurements

    Relative tyrosinase inhibition rate
    1.57 fold
    versus free EGCG

    Source sentences

    Summary
    The melanin inhibition rate is 5.22 times and the tyrosinase inhibition rate is 1.57 times that of free EGCG.
    1 context sentence
    Summary · context
    This study, to improve the stability and bioavailability of EGCG for reversing skin photo-aging, nonapeptide-1-conjugated mesoporous silica nanoparticles (EGCG@NP-MSN) were fabricated to load EGCG.

    In this study, Nonapeptide-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Nonapeptide-1.

  5. 05LabNot a test of Nonapeptide-1 aloneIn vitro (cells)Efficacy outcome

    In UV-exposed skin cells, the EGCG-loaded nonapeptide‑1 nanoparticle formulation significantly reduced DNA damage.

    In plain wordsIn cells exposed to UV, the EGCG-loaded nonapeptide‑1 nanoparticle formulation reduced DNA damage.

    Peptide
    Nonapeptide-1
    Outcome
    DecreaseUV-induced DNA damage
    Study

    n: not reported in source

    UV-exposed skin cells
    Outcome group
    Skin and hair · Skin and wound

    Source sentences

    Summary
    In vitro and in vivo results confirmed that the EGCG-loaded MSNs retained antioxidant properties, effectively scavenged the melanin and significantly reduced the deoxyribonucleic acid (DNA) damage in skin cells exposed to UV irradiation.
    1 context sentence
    Summary · context
    This study, to improve the stability and bioavailability of EGCG for reversing skin photo-aging, nonapeptide-1-conjugated mesoporous silica nanoparticles (EGCG@NP-MSN) were fabricated to load EGCG.

    In this study, Nonapeptide-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Nonapeptide-1.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.