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Study · Animal study (in vivo) · mouse · 2024

10 results

Spatial regulation of NMN supplementation on brain lipid metabolism upon subacute and sub-chronic PM exposure in C57BL/6 mice.

Jiang Y, Li F, Ye L, Zhang R, Chen S, Peng H, Zhang H, Li D, Chen L, Zeng X, Dong G, Xu W and 4 more

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Liao C, Zhang R, Luo Q, Chen W

Particle and fibre toxicology9 Sept 2024Cited by 4 (Europe PMC)

PMID39252011 (opens in a new tab)PMCIDPMC11385136 (opens in a new tab)DOI10.1186/s12989-024-00597-3 (opens in a new tab)PepBankPUB-39252011
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In PM-exposed mice, NMN increased brain NAD levels by 2.04 times.

    In plain wordsIn mice exposed to air particles, NMN increased brain NAD levels by 2.04 times.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseBrain NAD levels
    Study

    mousen: not reported in source

    PM-exposed C57BL/6 male mice
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    Brain NAD increase
    2.04 times
    NMN supplementation

    Source sentences

    Summary
    NMN supplementation boosted the level of nicotinamide adenine dinucleotide (NAD+) in the mouse brain by 2.04 times.
    1 context sentence
    Summary · context
    120 C57BL/6 male mice were exposed to real ambient PM for 11 days (subacute) or 16 weeks (sub-chronic).
  2. 02AnimalAnimal study (in vivo)Mechanism

    In PM-exposed mice, NMN reduced activated microglia across brain regions by 29.29 to 85.96%.

    In plain wordsIn mice exposed to air particles, NMN reduced activated brain immune cells by 29.29 to 85.96% across regions.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseActivated microglia
    Study

    mousen: not reported in source

    PM-exposed C57BL/6 male mice
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    Activated microglia reduction
    29.29 to 85.96%
    across brain regions

    Source sentences

    Summary
    This augmentation effectively reduced neuroinflammation, as evidenced by a marked decrease in activated microglia levels across various brain regions, ranging from 29.29 to 85.96%.
    1 context sentence
    Summary · context
    120 C57BL/6 male mice were exposed to real ambient PM for 11 days (subacute) or 16 weeks (sub-chronic).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice with subacute PM exposure, NMN limited the increase in brain ceramide levels.

    In plain wordsIn mice, NMN limited brain ceramide increases after short-term air particle exposure.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseBrain ceramide
    Study

    mousen: not reported in source

    PM-exposed C57BL/6 male mice
    Outcome group
    Lipids · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Whole brain lipidomics analysis revealed that NMN intervention resulted in an less increased levels of ceramide (Cer) and lysophospholipid in the brain following subacute PM exposure,
    1 context sentence
    Summary · context
    120 C57BL/6 male mice were exposed to real ambient PM for 11 days (subacute) or 16 weeks (sub-chronic).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice with subacute PM exposure, NMN limited the increase in brain lysophospholipid levels.

    In plain wordsIn mice, NMN limited brain lysophospholipid increases after short-term air particle exposure.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseBrain lysophospholipids
    Study

    mousen: not reported in source

    PM-exposed C57BL/6 male mice
    Outcome group
    Lipids · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Whole brain lipidomics analysis revealed that NMN intervention resulted in an less increased levels of ceramide (Cer) and lysophospholipid in the brain following subacute PM exposure,
    1 context sentence
    Summary · context
    120 C57BL/6 male mice were exposed to real ambient PM for 11 days (subacute) or 16 weeks (sub-chronic).
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice with sub-chronic PM exposure, NMN reversed brain triglyceride changes.

    In plain wordsIn mice, NMN reversed brain triglyceride changes after prolonged air particle exposure.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Direction not reportedBrain triglycerides
    Study

    mousen: not reported in source

    PM-exposed C57BL/6 male mice
    Outcome group
    Lipids · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    and reversed triglyceride (TG) and glycerophospholipids (GP) following sub-chronic PM exposure,
    1 context sentence
    Summary · context
    120 C57BL/6 male mice were exposed to real ambient PM for 11 days (subacute) or 16 weeks (sub-chronic).
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mice with sub-chronic PM exposure, NMN reversed brain glycerophospholipid changes.

    In plain wordsIn mice, NMN reversed brain glycerophospholipid changes after prolonged air particle exposure.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Direction not reportedBrain glycerophospholipids
    Study

    mousen: not reported in source

    PM-exposed C57BL/6 male mice
    Outcome group
    Lipids · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    and reversed triglyceride (TG) and glycerophospholipids (GP) following sub-chronic PM exposure,
    1 context sentence
    Summary · context
    120 C57BL/6 male mice were exposed to real ambient PM for 11 days (subacute) or 16 weeks (sub-chronic).
  7. 07AnimalAnimal study (in vivo)Mechanism

    In PM-exposed mice, NMN-associated lipid changes accompanied improved immune function.

    In plain wordsIn mice exposed to air particles, NMN-associated lipid changes accompanied improved immune function.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Direction not reportedImmune function
    Study

    mousen: not reported in source

    PM-exposed C57BL/6 male mice
    Outcome group
    Immune response · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    which conferred mice with anti-neuroinflammation response, improved immune function, and enhanced membrane stability.
    1 context sentence
    Summary · context
    120 C57BL/6 male mice were exposed to real ambient PM for 11 days (subacute) or 16 weeks (sub-chronic).
  8. 08AnimalAnimal study (in vivo)Mechanism

    In PM-exposed mice, NMN-associated lipid changes accompanied enhanced membrane stability.

    In plain wordsIn mice exposed to air particles, NMN-associated lipid changes accompanied improved membrane stability.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseMembrane stability
    Study

    mousen: not reported in source

    PM-exposed C57BL/6 male mice
    Outcome group
    Cytoskeleton and cell structure · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    which conferred mice with anti-neuroinflammation response, improved immune function, and enhanced membrane stability.
    1 context sentence
    Summary · context
    120 C57BL/6 male mice were exposed to real ambient PM for 11 days (subacute) or 16 weeks (sub-chronic).
  9. 09AnimalAnimal study (in vivo)Mechanism

    In mice, the hippocampus and hypothalamus might be most sensitive to PM exposure and NMN supplementation.

    In plain wordsIn mice, the hippocampus and hypothalamus might respond most strongly to air particles and NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Not applicableRegional sensitivity
    Study

    mousen: not reported in source

    PM-exposed C57BL/6 male mice
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, we demonstrated that the hippocampus and hypothalamus might be the most sensitive brain regions in response to PM exposure and NMN supplementation.
    1 context sentence
    Summary · context
    120 C57BL/6 male mice were exposed to real ambient PM for 11 days (subacute) or 16 weeks (sub-chronic).
  10. 10AnimalAnimal study (in vivo)Mechanism

    In PM-exposed mice, prominent TG, DG and LPC alterations correlated with pathways involving oxidative stress, inflammation and membrane instability.

    In plain wordsIn mice exposed to air particles, changes in TG, DG and LPC lipids correlated with oxidative stress, inflammation and membrane instability pathways.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Direction not reportedSpatial lipid-pathway correlations
    Study

    mousen: not reported in source

    PM-exposed C57BL/6 male mice
    Outcome group
    Lipids · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Particularly, the alteration of TG (60:10, 56:2, 60:7), diacylglycerol (DG, 42:6), and lysophosphatidylcholine (LPC, 18:3) are the most profound, which correlated with the changes in functional annotation and perturbation of pathways including oxidative stress, inflammation, and membrane instability…
    1 context sentence
    Summary · context
    120 C57BL/6 male mice were exposed to real ambient PM for 11 days (subacute) or 16 weeks (sub-chronic).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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