Achieving normoglycaemia with tirzepatide: Post hoc exploratory analysis of the SURPASS J-mono and J-combo studies.

Fujihara K, Matsubayashi Y, Kitazawa M, Sato T, Takeuchi M, Oura T, Sone H

Diabetes, obesity & metabolism27 Aug 2024Cited by 2 (Europe PMC)

PMID39192522DOI10.1111/dom.15887PepBankPUB-39192522

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. 8 results from people.

01HumanObservational studyEfficacy outcome
In Japanese adults with type 2 diabetes, 553 of 912 participants (60.6%) reached normoglycaemia (HbA1c <5.7%) after 52 weeks of tirzepatide.
In plain wordsIn Japanese adults with type 2 diabetes, about six in ten people on tirzepatide reached a normal HbA1c (below 5.7%) after 52 weeks.
Peptide
Tirzepatide
Outcome
Not applicableNormoglycaemia (HbA1c <5.7%) achievement at 52 weeks
Study
n = 912
Analysis
Exploratory
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated · 52 weeksAs given in this study (human).
Measurements
Participants achieving HbA1c <5.7%
60.6%
52 weeks tirzepatide
Source sentences
Summary
Of 912 participants, normoglycaemia was achieved in 553 (60.6%) following 52 weeks of tirzepatide treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
SURPASS J-mono and SURPASS J-combo study data were pooled for this analysis.
Summary · context
Characteristics of participants in whom normoglycaemia [glycated haemoglobin (HbA1c) <5.7%] was achieved were summarized.
Report a problemFND-3919252201
02HumanObservational studyEfficacy outcome
In Japanese adults with type 2 diabetes on tirzepatide, HbA1c fell by 2.87% in those who reached normoglycaemia and by 2.47% in those who did not.
In plain wordsIn Japanese adults on tirzepatide, HbA1c fell in both groups, more in people who reached normal blood sugar.
Peptide
Tirzepatide
Outcome
DecreaseHbA1c change from baseline by normoglycaemia status
Study
n = 912
Comparator
Participants who did not reach normoglycaemia
Analysis
Exploratory
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated · 52 weeksAs given in this study (human).
Measurements
HbA1c change
−2.87%
normoglycaemia reached
HbA1c change
−2.47%
normoglycaemia not reached
Source sentences
Summary
Mean (SD) change from baseline in HbA1c and bodyweight was -2.87% (0.95) versus -2.47% (1.1) and -10.30 (5.8) kg versus -3.75 (4.3) kg for participants in whom normoglycaemia was and was not reached, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
SURPASS J-mono and SURPASS J-combo study data were pooled for this analysis.
Summary · context
Characteristics of participants in whom normoglycaemia [glycated haemoglobin (HbA1c) <5.7%] was achieved were summarized.
Report a problemFND-3919252202
03HumanObservational studyEfficacy outcome
In Japanese adults with type 2 diabetes on tirzepatide, body weight fell by 10.30 kg in those who reached normoglycaemia and by 3.75 kg in those who did not.
In plain wordsIn Japanese adults with type 2 diabetes on tirzepatide, weight fell in both groups, much more in people who reached normal blood sugar.
Peptide
Tirzepatide
Outcome
DecreaseBody weight change from baseline by normoglycaemia status
Study
n = 912
Comparator
Participants who did not reach normoglycaemia
Analysis
Exploratory
Outcome group
Body weight · Metabolic and weight
Studied dose
Dose not stated · 52 weeksAs given in this study (human).
Measurements
Body weight change
−10.3 kg
normoglycaemia reached
Body weight change
−3.75 kg
normoglycaemia not reached
Source sentences
Summary
Mean (SD) change from baseline in HbA1c and bodyweight was -2.87% (0.95) versus -2.47% (1.1) and -10.30 (5.8) kg versus -3.75 (4.3) kg for participants in whom normoglycaemia was and was not reached, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
SURPASS J-mono and SURPASS J-combo study data were pooled for this analysis.
Summary · context
Characteristics of participants in whom normoglycaemia [glycated haemoglobin (HbA1c) <5.7%] was achieved were summarized.
Report a problemFND-3919252203
04HumanObservational studyOther
In Japanese adults with type 2 diabetes on tirzepatide, a lower baseline body mass index was significantly associated with a higher rate of normoglycaemia (p = 0.009).
In plain wordsIn Japanese adults on tirzepatide, a lower starting body mass index was linked to a higher chance of reaching normal blood sugar.
Peptide
Tirzepatide
Outcome
Not applicableBaseline BMI as predictor of normoglycaemia
Study
n = 912
Analysis
Exploratory
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated · 52 weeksAs given in this study (human).
Source sentences
Summary
Multivariate regression analyses showed that lower baseline body mass index, shorter disease duration and lower baseline HbA1c were significantly associated with higher rates of normoglycaemia achievement (p = 0.009, p = 0.008, p < 0.001, respectively) as was a tirzepatide dose of 10 or 15 mg compar…
2 context sentences(design, population, supporting numbers)
Summary · context
SURPASS J-mono and SURPASS J-combo study data were pooled for this analysis.
Summary · context
Characteristics of participants in whom normoglycaemia [glycated haemoglobin (HbA1c) <5.7%] was achieved were summarized.
Report a problemFND-3919252204
05HumanObservational studyOther
In Japanese adults with type 2 diabetes on tirzepatide, a shorter disease duration was significantly associated with a higher rate of normoglycaemia (p = 0.008).
In plain wordsIn Japanese adults with type 2 diabetes on tirzepatide, a shorter time since diagnosis was linked to a higher chance of reaching normal blood sugar.
Peptide
Tirzepatide
Outcome
Not applicableDiabetes duration as predictor of normoglycaemia
Study
n = 912
Analysis
Exploratory
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated · 52 weeksAs given in this study (human).
Source sentences
Summary
Multivariate regression analyses showed that lower baseline body mass index, shorter disease duration and lower baseline HbA1c were significantly associated with higher rates of normoglycaemia achievement (p = 0.009, p = 0.008, p < 0.001, respectively) as was a tirzepatide dose of 10 or 15 mg compar…
2 context sentences(design, population, supporting numbers)
Summary · context
SURPASS J-mono and SURPASS J-combo study data were pooled for this analysis.
Summary · context
Characteristics of participants in whom normoglycaemia [glycated haemoglobin (HbA1c) <5.7%] was achieved were summarized.
Report a problemFND-3919252205
06HumanObservational studyOther
In Japanese adults with type 2 diabetes on tirzepatide, a lower baseline HbA1c was significantly associated with a higher rate of normoglycaemia (p < 0.001).
In plain wordsIn Japanese adults with type 2 diabetes on tirzepatide, a lower starting HbA1c was linked to a higher chance of reaching normal blood sugar.
Peptide
Tirzepatide
Outcome
Not applicableBaseline HbA1c as predictor of normoglycaemia
Study
n = 912
Analysis
Exploratory
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated · 52 weeksAs given in this study (human).
Source sentences
Summary
Multivariate regression analyses showed that lower baseline body mass index, shorter disease duration and lower baseline HbA1c were significantly associated with higher rates of normoglycaemia achievement (p = 0.009, p = 0.008, p < 0.001, respectively) as was a tirzepatide dose of 10 or 15 mg compar…
3 context sentences(design, population, supporting numbers)
Summary · context
A lower baseline HbA1c was most strongly associated with normoglycaemia achievement.
Summary · context
SURPASS J-mono and SURPASS J-combo study data were pooled for this analysis.
Summary · context
Characteristics of participants in whom normoglycaemia [glycated haemoglobin (HbA1c) <5.7%] was achieved were summarized.
Report a problemFND-3919252206
07HumanObservational studyEfficacy outcome
In Japanese adults with type 2 diabetes, a tirzepatide dose of 10 or 15 mg was associated with higher rates of normoglycaemia than 5 mg (p < 0.001).
In plain wordsIn Japanese adults with type 2 diabetes, more people reached normal blood sugar on tirzepatide 10 or 15 mg than on 5 mg.
Peptide
Tirzepatide
Outcome
IncreaseNormoglycaemia by tirzepatide dose (10 or 15 mg versus 5 mg)
Study
n = 912
Comparator
Tirzepatide 5 mg
Analysis
Exploratory
Outcome group
Glycemic control · Metabolic and weight
Studied dose
10 mg or 15 mg versus 5 mg · 52 weeksAs given in this study (human).
Source sentences
Summary
Multivariate regression analyses showed that lower baseline body mass index, shorter disease duration and lower baseline HbA1c were significantly associated with higher rates of normoglycaemia achievement (p = 0.009, p = 0.008, p < 0.001, respectively) as was a tirzepatide dose of 10 or 15 mg compar…
2 context sentences(design, population, supporting numbers)
Summary · context
SURPASS J-mono and SURPASS J-combo study data were pooled for this analysis.
Summary · context
Characteristics of participants in whom normoglycaemia [glycated haemoglobin (HbA1c) <5.7%] was achieved were summarized.
Report a problemFND-3919252207
08HumanObservational studyEfficacy outcome
In Japanese adults with type 2 diabetes on tirzepatide, 94% of those with baseline HbA1c below 8% and weight reduction of 15% or more achieved normoglycaemia.
In plain wordsIn Japanese adults with type 2 diabetes on tirzepatide, 94% of those with lower starting HbA1c and the greatest weight loss reached normal blood sugar.
Peptide
Tirzepatide
Outcome
Not applicableNormoglycaemia in participants with low baseline HbA1c and large weight loss
Study
n: not reported in source
Analysis
Exploratory
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated · 52 weeksAs given in this study (human).
Measurements
Participants achieving normoglycaemia
94%
baseline HbA1c <8% and weight reduction >=15%
Source sentences
Summary
The highest percentage of participants in whom normoglycaemia (94%) was achieved were those with lower baseline HbA1c (<8%) and the greatest weight reduction (≥15%).
2 context sentences(design, population, supporting numbers)
Summary · context
SURPASS J-mono and SURPASS J-combo study data were pooled for this analysis.
Summary · context
Characteristics of participants in whom normoglycaemia [glycated haemoglobin (HbA1c) <5.7%] was achieved were summarized.
Report a problemFND-3919252208

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 03:07 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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Achieving normoglycaemia with tirzepatide: Post hoc exploratory analysis of the SURPASS J-mono and J-combo studies.

Summary

Results from this study8

Version history

Subjects

Publication types

MeSH terms

Keywords