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Study · Not a test of the peptide alone · 2024

6 results

Clinical Safety and Efficacy Evaluation of a Dissolving Microneedle Patch Having Dual Anti-Wrinkle Effects With Safe and Long-Term Activities.

Shin JY, Han D, Yoon KY, Jeong DH, Park YI

Annals of dermatology1 Aug 2024Cited by 7 (Europe PMC)

PMID39082657 (opens in a new tab)PMCIDPMC11291098 (opens in a new tab)DOI10.5021/ad.23.136 (opens in a new tab)PepBankPUB-39082657
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone6

In this study, SNAP-8 (acetyl octapeptide-3) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking SNAP-8 (acetyl octapeptide-3).

  1. 01HumanNot a test of SNAP-8 (acetyl octapeptide-3) aloneNon-randomized trialEfficacy outcome

    In healthy subjects, the multi-ingredient DA-MNP improved eye wrinkles versus the HA-only placebo patch.

    In plain wordsIn healthy subjects, the multi-ingredient DA-MNP improved eye wrinkles compared with the HA-only placebo patch.

    Peptide
    SNAP-8 (acetyl octapeptide-3)
    Outcome
    DecreaseEye wrinkles
    Study

    n = 24

    Comparator
    HA-only placebo microneedle patch
    Outcome group
    Skin and hair · Skin and wound

    Source sentences

    Summary
    Compared to placebo MNP group, the DA-MNP treated group showed an effective eye wrinkles improvement and better anti-aging of skin, with reduced TEWL, enhanced skin elasticity and lifting, and no adverse effects.
    3 context sentences
    Summary · context
    A DA-MNP comprising hyaluronic acid (HA) polymer backbone, acetyl octapeptide-3, and L-ascorbic acid 2-glucoside and sodium cyclic lysophosphatidic acid was fabricated using DEN® technology.
    Summary · context
    Twenty-four healthy subjects were enrolled in this comparative clinical study.
    Summary · context
    The DA-MNP or placebo MNP was separately applied to the left and right eyes of subjects for overnight.

    In this study, SNAP-8 (acetyl octapeptide-3) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking SNAP-8 (acetyl octapeptide-3).

  2. 02HumanNot a test of SNAP-8 (acetyl octapeptide-3) aloneNon-randomized trialEfficacy outcome

    In healthy subjects, the multi-ingredient DA-MNP reduced trans-epidermal water loss versus the HA-only placebo patch.

    In plain wordsIn healthy subjects, the multi-ingredient DA-MNP reduced skin water loss compared with the HA-only placebo patch.

    Peptide
    SNAP-8 (acetyl octapeptide-3)
    Outcome
    DecreaseTrans-epidermal water loss
    Study

    n = 24

    Comparator
    HA-only placebo microneedle patch
    Outcome group
    Skin and hair · Skin and wound

    Source sentences

    Summary
    Compared to placebo MNP group, the DA-MNP treated group showed an effective eye wrinkles improvement and better anti-aging of skin, with reduced TEWL, enhanced skin elasticity and lifting, and no adverse effects.
    3 context sentences
    Summary · context
    A DA-MNP comprising hyaluronic acid (HA) polymer backbone, acetyl octapeptide-3, and L-ascorbic acid 2-glucoside and sodium cyclic lysophosphatidic acid was fabricated using DEN® technology.
    Summary · context
    Twenty-four healthy subjects were enrolled in this comparative clinical study.
    Summary · context
    The DA-MNP or placebo MNP was separately applied to the left and right eyes of subjects for overnight.

    In this study, SNAP-8 (acetyl octapeptide-3) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking SNAP-8 (acetyl octapeptide-3).

  3. 03HumanNot a test of SNAP-8 (acetyl octapeptide-3) aloneNon-randomized trialEfficacy outcome

    In healthy subjects, the multi-ingredient DA-MNP enhanced skin elasticity versus the HA-only placebo patch.

    In plain wordsIn healthy subjects, the multi-ingredient DA-MNP improved skin elasticity compared with the HA-only placebo patch.

    Peptide
    SNAP-8 (acetyl octapeptide-3)
    Outcome
    IncreaseSkin elasticity
    Study

    n = 24

    Comparator
    HA-only placebo microneedle patch
    Outcome group
    Skin and hair · Skin and wound

    Source sentences

    Summary
    Compared to placebo MNP group, the DA-MNP treated group showed an effective eye wrinkles improvement and better anti-aging of skin, with reduced TEWL, enhanced skin elasticity and lifting, and no adverse effects.
    3 context sentences
    Summary · context
    A DA-MNP comprising hyaluronic acid (HA) polymer backbone, acetyl octapeptide-3, and L-ascorbic acid 2-glucoside and sodium cyclic lysophosphatidic acid was fabricated using DEN® technology.
    Summary · context
    Twenty-four healthy subjects were enrolled in this comparative clinical study.
    Summary · context
    The DA-MNP or placebo MNP was separately applied to the left and right eyes of subjects for overnight.

    In this study, SNAP-8 (acetyl octapeptide-3) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking SNAP-8 (acetyl octapeptide-3).

  4. 04HumanNot a test of SNAP-8 (acetyl octapeptide-3) aloneNon-randomized trialEfficacy outcome

    In healthy subjects, the multi-ingredient DA-MNP enhanced skin lifting versus the HA-only placebo patch.

    In plain wordsIn healthy subjects, the multi-ingredient DA-MNP improved skin lifting compared with the HA-only placebo patch.

    Peptide
    SNAP-8 (acetyl octapeptide-3)
    Outcome
    IncreaseSkin lifting
    Study

    n = 24

    Comparator
    HA-only placebo microneedle patch
    Outcome group
    Skin and hair · Skin and wound

    Source sentences

    Summary
    Compared to placebo MNP group, the DA-MNP treated group showed an effective eye wrinkles improvement and better anti-aging of skin, with reduced TEWL, enhanced skin elasticity and lifting, and no adverse effects.
    3 context sentences
    Summary · context
    A DA-MNP comprising hyaluronic acid (HA) polymer backbone, acetyl octapeptide-3, and L-ascorbic acid 2-glucoside and sodium cyclic lysophosphatidic acid was fabricated using DEN® technology.
    Summary · context
    Twenty-four healthy subjects were enrolled in this comparative clinical study.
    Summary · context
    The DA-MNP or placebo MNP was separately applied to the left and right eyes of subjects for overnight.

    In this study, SNAP-8 (acetyl octapeptide-3) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking SNAP-8 (acetyl octapeptide-3).

  5. 05HumanNot a test of SNAP-8 (acetyl octapeptide-3) aloneNon-randomized trialSafety outcome

    In healthy subjects, the multi-ingredient DA-MNP produced no reported adverse effects.

    In plain wordsIn healthy subjects, the multi-ingredient DA-MNP produced no reported adverse effects.

    Peptide
    SNAP-8 (acetyl octapeptide-3)
    Outcome
    Not applicableAdverse effects
    Study

    n = 24

    Outcome group
    Adverse events · Skin and wound

    Source sentences

    Summary
    Compared to placebo MNP group, the DA-MNP treated group showed an effective eye wrinkles improvement and better anti-aging of skin, with reduced TEWL, enhanced skin elasticity and lifting, and no adverse effects.
    3 context sentences
    Summary · context
    A DA-MNP comprising hyaluronic acid (HA) polymer backbone, acetyl octapeptide-3, and L-ascorbic acid 2-glucoside and sodium cyclic lysophosphatidic acid was fabricated using DEN® technology.
    Summary · context
    Twenty-four healthy subjects were enrolled in this comparative clinical study.
    Summary · context
    The DA-MNP or placebo MNP was separately applied to the left and right eyes of subjects for overnight.

    In this study, SNAP-8 (acetyl octapeptide-3) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking SNAP-8 (acetyl octapeptide-3).

  6. 06LabNot a test of SNAP-8 (acetyl octapeptide-3) aloneOther designActivity measurement

    In laboratory assessment, the multi-ingredient DA-MNP had sufficient mechanical strength to puncture the stratum corneum.

    In plain wordsIn lab tests, the multi-ingredient DA-MNP was strong enough to puncture the outer skin layer.

    Peptide
    SNAP-8 (acetyl octapeptide-3)
    Outcome
    Not applicableStratum corneum puncture capability
    Study

    n: not reported in source

    Microneedle patch
    Outcome group
    Skin and hair · Skin and wound

    Source sentences

    Summary
    The DA-MNP showed mechanical strength enough for puncturing the stratum corneum.
    1 context sentence
    Summary · context
    A DA-MNP comprising hyaluronic acid (HA) polymer backbone, acetyl octapeptide-3, and L-ascorbic acid 2-glucoside and sodium cyclic lysophosphatidic acid was fabricated using DEN® technology.

    In this study, SNAP-8 (acetyl octapeptide-3) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking SNAP-8 (acetyl octapeptide-3).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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