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Study · Animal study (in vivo) · mouse · 2024

2 results

Effect of Humanin and MOTS-c on ameliorating reproductive damage induced by prepubertal cyclophosphamide chemotherapy in male mice.

Wang J, Wen W, Liu L, He J, Deng R, Su M, Zhao S, Wang H, Rao M, Tang L

Reproductive toxicology (Elmsford, N.Y.)28 Jul 2024Cited by 7 (Europe PMC)

PMID39079574 (opens in a new tab)DOI10.1016/j.reprotox.2024.108674 (opens in a new tab)PepBankPUB-39079574
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male mice given prepubertal cyclophosphamide chemotherapy, MOTS‑c protected testicular spermatogenic function from reproductive injury.

    In plain wordsIn male mice, MOTS‑c protected sperm-producing function in the testes from damage caused by chemotherapy given before puberty.

    Peptide
    MOTS-c
    Outcome
    IncreaseTesticular spermatogenic function after prepubertal chemotherapy
    Study

    mousen: not reported in source

    Prepubertal cyclophosphamide chemotherapy
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here, we found that in vivo, mitochondrial polypeptides Humanin analog (HNG) and MOTS-c efficaciously protected the testicular spermatogenic function from reproductive injury.
    1 context sentence
    Title · context
    Effect of Humanin and MOTS-c on ameliorating reproductive damage induced by prepubertal cyclophosphamide chemotherapy in male mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In male mice given prepubertal cyclophosphamide, the humanin analogue HNG protected testicular spermatogenic function from reproductive injury.

    In plain wordsIn male mice given chemotherapy before puberty, a humanin analogue protected the testes' sperm-making function.

    Peptide
    Humanin
    Outcome
    IncreaseTesticular spermatogenic function after prepubertal chemotherapy
    Study

    mousen: not reported in source

    Male mice with prepubertal cyclophosphamide chemotherapy
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here, we found that in vivo, mitochondrial polypeptides Humanin analog (HNG) and MOTS-c efficaciously protected the testicular spermatogenic function from reproductive injury.
    1 context sentence
    Title · context
    Effect of Humanin and MOTS-c on ameliorating reproductive damage induced by prepubertal cyclophosphamide chemotherapy in male mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 4 to 18Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 15 times, first on 13 Oct 2026, 21:44 UTC. The status did not change between them.

    Study results updated

  2. Version 3

    13 Oct 2026, 16:31 UTC

    Study data updated · source update from Europe PMC

  3. Version 2

    9 Oct 2026, 18:17 UTC

    Study results updated

  4. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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