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Study · Measured the body's own peptide · 2022

6 results

The Effect of Chronic Endurance Exercise on Serum Levels of MOTS-c and Humanin in Professional Athletes.

Alser M, Ramanjaneya M, Rizwana Anwardeen N, Donati F, Botrè F, Jerobin J, Bettahi I, Mohamed NA, Abou-Samra AB, Elrayess MA

Reviews in cardiovascular medicine18 May 2022Cited by 8 (Europe PMC)

PMID39077591 (opens in a new tab)PMCIDPMC11273660 (opens in a new tab)DOI10.31083/j.rcm2305181 (opens in a new tab)PepBankPUB-39077591
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Summary

BackgroundHumanin and the mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) are mitochondrial encoded peptides involved in energy metabolism, cytoprotection, longevity, insulin sensitivity and their expression decrease with age. Levels of these molecules have been shown to respond to acute exercise, however little is known about their modulation under different chronic exercise conditions. In this study, we aim to compare levels of Humanin and MOTS-c in non-athletes vs professional (moderate and high endurance) athletes.MethodsSerum samples were collected from 30 non-athlete controls and 75 professional athletes (47 low/moderate endurance and 28 high endurance athletes). Levels of Humanin and MOTS-c were measured by the enzyme linked immunosorbent aaasy (ELISA) and linear models were generated to compare the effect of different levels of endurance exercise on these factors in different age groups. Spearman correlation was used to assess the correlation between these factors in athletes and non-athletes.ResultsWe showed that professional athletes had lower levels of MOTS-c and higher levels of Humanin than sedentary controls. Within the athletic groups, high endurance athletes had lower levels of Humanin than low/moderate endurance athletes of the same gender/age groups, whereas MOTS-c levels did not change between the subgroups. Humanin and MOTS-c levels were highly correlated in athletes, but not in sedentary controls.ConclusionsThis pilot data suggests that serum levels of the mitochondrial proteins MOTS-c and Humanin change in response to chronic exercise with implications on energy metabolism and performance.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study6

No result from this study comes from a test of the peptide.

Natural levels measured6

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In professional endurance athletes, the body's own serum MOTS‑c levels were lower than in sedentary controls.

    In plain wordsProfessional athletes had lower natural MOTS‑c levels in blood than people who did not exercise regularly.

    Peptide
    MOTS-c
    Outcome
    DecreaseSerum MOTS-c in professional athletes versus sedentary controls
    Study

    n = 105

    Comparator
    Non-athlete controls
    Outcome group
    Exercise and physical function · Metabolic and weight

    Source sentences

    Summary
    professional athletes had lower levels of MOTS-c and higher levels of Humanin than sedentary controls
    1 context sentence
    Summary · context
    Serum samples were collected from 30 non-athlete controls and 75 professional athletes (47 low/moderate endurance and 28 high endurance athletes).

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    Serum levels of the body's own MOTS‑c and Humanin were highly correlated in athletes, but not in sedentary controls.

    In plain wordsNatural MOTS‑c and Humanin levels moved together in athletes, but not in people who did not exercise regularly.

    Peptide
    MOTS-c
    Outcome
    Not applicableCorrelation of MOTS-c with Humanin levels
    Study

    n = 105

    Outcome group
    Exercise and physical function · Metabolic and weight

    Source sentences

    Summary
    Humanin and MOTS-c levels were highly correlated in athletes, but not in sedentary controls.
    1 context sentence
    Summary · context
    Serum samples were collected from 30 non-athlete controls and 75 professional athletes (47 low/moderate endurance and 28 high endurance athletes).

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    Professional endurance athletes had higher serum humanin levels than sedentary controls.

    In plain wordsProfessional athletes had higher levels of the body's own humanin than sedentary people.

    Peptide
    Humanin
    Outcome
    IncreaseSerum humanin, athletes versus sedentary controls
    Study

    n = 105

    Comparator
    Non-athlete controls
    Outcome group
    Exercise and physical function · Whole body

    Source sentences

    Summary
    higher levels of Humanin than sedentary controls.
    2 context sentences
    Summary · context
    Serum samples were collected from 30 non-athlete controls and 75 professional athletes (47 low/moderate endurance and 28 high endurance athletes).
    Summary · context
    Levels of Humanin and MOTS-c were measured by the enzyme linked immunosorbent aaasy (ELISA) and linear models were generated to compare the effect of different levels of endurance exercise on these factors in different age groups.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    Among professional athletes, the body's own serum MOTS‑c levels did not differ between high endurance and low/moderate endurance athletes.

    In plain wordsAmong athletes, natural MOTS‑c levels were similar in high endurance and low or moderate endurance athletes.

    Peptide
    MOTS-c
    Outcome
    No significant changeSerum MOTS-c across endurance levels within athletes
    Study

    n = 75

    Comparator
    Low/moderate endurance athletes
    Outcome group
    Exercise and physical function · Metabolic and weight

    Source sentences

    Summary
    whereas MOTS-c levels did not change between the subgroups.
    1 context sentence
    Summary · context
    Serum samples were collected from 30 non-athlete controls and 75 professional athletes (47 low/moderate endurance and 28 high endurance athletes).

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

  5. 05HumanEndogenous levelObservational studyOther

    High endurance athletes had lower serum humanin levels than low/moderate endurance athletes of the same gender and age group.

    In plain wordsHigh endurance athletes had lower levels of the body's own humanin than low or moderate endurance athletes of the same age and gender.

    Peptide
    Humanin
    Outcome
    DecreaseSerum humanin, high versus low/moderate endurance athletes
    Study

    n = 75

    Comparator
    Low/moderate endurance athletes
    Outcome group
    Exercise and physical function · Whole body

    Source sentences

    Summary
    high endurance athletes had lower levels of Humanin than low/moderate endurance athletes of the same gender/age groups
    2 context sentences
    Summary · context
    Serum samples were collected from 30 non-athlete controls and 75 professional athletes (47 low/moderate endurance and 28 high endurance athletes).
    Summary · context
    Levels of Humanin and MOTS-c were measured by the enzyme linked immunosorbent aaasy (ELISA) and linear models were generated to compare the effect of different levels of endurance exercise on these factors in different age groups.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  6. 06HumanEndogenous levelObservational studyOther

    Serum humanin and MOTS-c levels were highly correlated in athletes but not in sedentary controls.

    In plain wordsIn athletes, the body's own humanin levels were closely linked to MOTS-c levels. This link was not seen in sedentary controls.

    Peptide
    Humanin
    Outcome
    Not applicableCorrelation of serum humanin with MOTS-c
    Study

    n: not reported in source

    Comparator
    Sedentary controls
    Outcome group
    Exercise and physical function · Whole body

    Source sentences

    Summary
    Humanin and MOTS-c levels were highly correlated in athletes, but not in sedentary controls.
    2 context sentences
    Summary · context
    Serum samples were collected from 30 non-athlete controls and 75 professional athletes (47 low/moderate endurance and 28 high endurance athletes).
    Summary · context
    Levels of Humanin and MOTS-c were measured by the enzyme linked immunosorbent aaasy (ELISA) and linear models were generated to compare the effect of different levels of endurance exercise on these factors in different age groups.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 4 to 18Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 15 times, first on 13 Oct 2026, 21:44 UTC. The status did not change between them.

    Study results updated

  2. Version 3

    13 Oct 2026, 16:31 UTC

    Study data updated · source update from Europe PMC

  3. Version 2

    10 Oct 2026, 08:19 UTC

    Study results updated

  4. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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