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Study · Measured the body's own peptide · 2024

5 results

Restoring energy metabolism by NAD+ supplement prevents alcohol-induced liver injury and boosts liver regeneration.

Liu Y, Cheng C, Gao H, Zhu XJ, He X, Zhou MX, Gao Y, Lu YW, Song XH, Xiao XH, Wang JB, Xu CJ, Ma ZT

Food science & nutrition22 Apr 2024Cited by 9 (Europe PMC)

PMID39055233 (opens in a new tab)PMCIDPMC11266918 (opens in a new tab)DOI10.1002/fsn3.4159 (opens in a new tab)PepBankPUB-39055233
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Summary

Our previous clinical metabolomics study illustrated that energy metabolism disorder is an underlying pathogenesis mechanism for the development of alcoholic liver disease (ALD). Supplementation of nicotinamide (NAM), the precursor of nicotinamide adenine dinucleotide (NAD+), may restore the energy metabolism homeostasis of ALD and thus serves as potential therapeutics to treat ALD. In this bedside-to-bench study, the protective effect of NAM against ALD was investigated by using the NIAAA mice model (chronic-plus-binge ethanol), and the liver regeneration boosting capability of NAM was evaluated by the partial hepatectomy mice model. Our results showed that NAM supplements not only protected the liver from alcohol-induced injury and improved alcohol-induced mitochondrial structure and function change, but also boosted liver regeneration in postpartial hepatectomy mice by increasing liver NAD+ content. These findings suggested that NAM, a water-soluble form of vitamin B3, can promote liver regeneration and improves liver function by alleviating alcohol-induced energy metabolism disorder.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In partially hepatectomized mice, NAM increased natural liver NAD content.

    In plain wordsIn mice after partial liver removal, NAM increased the body's own liver NAD content.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseLiver NAD content
    Study

    mousen: not reported in source

    Partial hepatectomy mice
    Outcome group
    Mitochondrial function · Liver

    Source sentences

    Summary
    Our results showed that NAM supplements not only protected the liver from alcohol-induced injury and improved alcohol-induced mitochondrial structure and function change, but also boosted liver regeneration in postpartial hepatectomy mice by increasing liver NAD+ content.
    1 context sentence
    Summary · context
    In this bedside-to-bench study, the protective effect of NAM against ALD was investigated by using the NIAAA mice model (chronic-plus-binge ethanol), and the liver regeneration boosting capability of NAM was evaluated by the partial hepatectomy mice model.

    This result measures the body's own NAD+ (nicotinamide adenine dinucleotide). Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone4

In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking NAD+ (nicotinamide adenine dinucleotide).

  1. 02AnimalNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneAnimal study (in vivo)Efficacy outcome

    In alcohol-exposed mice, NAM, an NAD precursor, protected the liver from alcohol-induced injury.

    In plain wordsIn mice exposed to alcohol, the NAD precursor NAM reduced liver injury.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseAlcohol-induced liver injury
    Study

    mousen: not reported in source

    NIAAA chronic-plus-binge ethanol mice
    Outcome group
    Liver fat and liver function · Liver

    Source sentences

    Summary
    Our results showed that NAM supplements not only protected the liver from alcohol-induced injury
    1 context sentence
    Summary · context
    In this bedside-to-bench study, the protective effect of NAM against ALD was investigated by using the NIAAA mice model (chronic-plus-binge ethanol), and the liver regeneration boosting capability of NAM was evaluated by the partial hepatectomy mice model.

    In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).

  2. 03AnimalNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneAnimal study (in vivo)Mechanism

    In alcohol-exposed mice, NAM, an NAD precursor, improved alcohol-induced mitochondrial structural changes.

    In plain wordsIn mice exposed to alcohol, the NAD precursor NAM improved mitochondrial structure.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    Not applicableMitochondrial structure
    Study

    mousen: not reported in source

    NIAAA chronic-plus-binge ethanol mice
    Outcome group
    Mitochondrial function · Liver

    Source sentences

    Summary
    Our results showed that NAM supplements not only protected the liver from alcohol-induced injury and improved alcohol-induced mitochondrial structure and function change, but also boosted liver regeneration in postpartial hepatectomy mice by increasing liver NAD+ content.
    1 context sentence
    Summary · context
    In this bedside-to-bench study, the protective effect of NAM against ALD was investigated by using the NIAAA mice model (chronic-plus-binge ethanol), and the liver regeneration boosting capability of NAM was evaluated by the partial hepatectomy mice model.

    In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).

  3. 04AnimalNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneAnimal study (in vivo)Mechanism

    In alcohol-exposed mice, NAM, an NAD precursor, improved alcohol-induced mitochondrial functional changes.

    In plain wordsIn mice exposed to alcohol, the NAD precursor NAM improved mitochondrial function.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    Not applicableMitochondrial function
    Study

    mousen: not reported in source

    NIAAA chronic-plus-binge ethanol mice
    Outcome group
    Mitochondrial function · Liver

    Source sentences

    Summary
    Our results showed that NAM supplements not only protected the liver from alcohol-induced injury and improved alcohol-induced mitochondrial structure and function change, but also boosted liver regeneration in postpartial hepatectomy mice by increasing liver NAD+ content.
    1 context sentence
    Summary · context
    In this bedside-to-bench study, the protective effect of NAM against ALD was investigated by using the NIAAA mice model (chronic-plus-binge ethanol), and the liver regeneration boosting capability of NAM was evaluated by the partial hepatectomy mice model.

    In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).

  4. 05AnimalNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneAnimal study (in vivo)Efficacy outcome

    In partially hepatectomized mice, NAM boosted liver regeneration by increasing liver NAD content.

    In plain wordsIn mice after partial liver removal, NAM increased liver regeneration through increased NAD content.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseLiver regeneration
    Study

    mousen: not reported in source

    Partial hepatectomy mice
    Outcome group
    Liver fat and liver function · Liver

    Source sentences

    Summary
    Our results showed that NAM supplements not only protected the liver from alcohol-induced injury and improved alcohol-induced mitochondrial structure and function change, but also boosted liver regeneration in postpartial hepatectomy mice by increasing liver NAD+ content.
    1 context sentence
    Summary · context
    In this bedside-to-bench study, the protective effect of NAM against ALD was investigated by using the NIAAA mice model (chronic-plus-binge ethanol), and the liver regeneration boosting capability of NAM was evaluated by the partial hepatectomy mice model.

    In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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