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Study · Animal study (in vivo) · ferret · 2024

4 results

The growth hormone secretagogue receptor 1a agonists, anamorelin and ipamorelin, inhibit cisplatin-induced weight loss in ferrets: Anamorelin also exhibits anti-emetic effects via a central mechanism.

Lu Z, Ngan MP, Liu JYH, Yang L, Tu L, Chan SW, Giuliano C, Lovati E, Pietra C, Rudd JA

Physiology & behavior21 Jul 2024

PMID39043357 (opens in a new tab)DOI10.1016/j.physbeh.2024.114644 (opens in a new tab)PepBankPUB-39043357
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In ferrets given cisplatin, intraperitoneal ipamorelin did not affect acute emesis.

    In plain wordsIn ferrets given cisplatin, ipamorelin by injection into the abdomen did not change early vomiting.

    Peptide
    Ipamorelin
    Outcome
    No significant changeCisplatin-induced acute emesis
    Study

    ferretn: not reported in source

    Cisplatin-induced emesis model
    Comparator
    Vehicle
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    1-3 mg/kg · intraperitoneal · up to 72 hAs given in this study (ferret).

    Source sentences

    Summary
    Neither of compounds administered i.p. had any effect on cisplatin-induced acute or delayed emesis
    1 context sentence
    Summary · context
    In other experiments, ferrets were administered anamorelin (1-3 mg/kg), ipamorelin (1-3 mg/kg), or vehicle intraperitoneally (i.p.) 30 s before cisplatin (5 mg/kg, i.p.) and then every 24 h, and their behaviour was recorded for up to 72 h.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In ferrets given cisplatin, intraperitoneal ipamorelin did not affect delayed emesis.

    In plain wordsIn ferrets given cisplatin, ipamorelin by injection into the abdomen did not change late vomiting.

    Peptide
    Ipamorelin
    Outcome
    No significant changeCisplatin-induced delayed emesis
    Study

    ferretn: not reported in source

    Cisplatin-induced emesis model
    Comparator
    Vehicle
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    1-3 mg/kg · intraperitoneal · up to 72 hAs given in this study (ferret).

    Source sentences

    Summary
    Neither of compounds administered i.p. had any effect on cisplatin-induced acute or delayed emesis
    1 context sentence
    Summary · context
    In other experiments, ferrets were administered anamorelin (1-3 mg/kg), ipamorelin (1-3 mg/kg), or vehicle intraperitoneally (i.p.) 30 s before cisplatin (5 mg/kg, i.p.) and then every 24 h, and their behaviour was recorded for up to 72 h.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In ferrets given cisplatin, intraperitoneal ipamorelin inhibited weight loss on the last day of the delayed phase (48-72 h) by approximately 24 % compared with vehicle.

    In plain wordsIn ferrets given cisplatin, ipamorelin reduced weight loss late in the study compared with vehicle.

    Peptide
    Ipamorelin
    Outcome
    DecreaseCisplatin-induced weight loss on last day of delayed phase
    Study

    ferretn: not reported in source

    Cisplatin-induced emesis model
    Comparator
    Vehicle
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    1-3 mg/kg · intraperitoneal · up to 72 hAs given in this study (ferret).

    Measurements

    Reduction in cisplatin-induced weight loss
    ≈ 24%
    last day of delayed phase (48-72 h)

    Source sentences

    Summary
    both inhibited associated cisplatin-induced weight loss on the last day of delayed phase (48-72 h) by approximately 24 %.
    1 context sentence
    Summary · context
    In other experiments, ferrets were administered anamorelin (1-3 mg/kg), ipamorelin (1-3 mg/kg), or vehicle intraperitoneally (i.p.) 30 s before cisplatin (5 mg/kg, i.p.) and then every 24 h, and their behaviour was recorded for up to 72 h.
  4. 04LabEx vivo tissueActivity measurement

    In isolated ferret ileum, ipamorelin inhibited electrical field stimulation-induced contractions by 54.4 % (IC50 11.7 µM).

    In plain wordsIn lab tests on ferret gut tissue, ipamorelin reduced electrically induced contractions of the ileum.

    Peptide
    Ipamorelin
    Outcome
    DecreaseInhibition of EFS-induced ileum contraction
    Study

    ferretn: not reported in source

    Isolated ileum with electrical field stimulation
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    Dose not stated

    Measurements

    Inhibition of EFS-induced contraction
    54.4%
    isolated ferret ileum
    IC50
    11.7 µM
    isolated ferret ileum

    Source sentences

    Summary
    Anamorelin and ipamorelin inhibited EFS-induced contractions of isolated ileum by 94.4 % (half-maximal inhibitory concentration [IC50]=14.0 µM) and 54.4 % (IC50=11.7 µM), respectively.
    1 context sentence
    Summary · context
    The potential of anamorelin to inhibit electrical field stimulation (EFS)-induced contractions of isolated ferret ileum was compared with ipamorelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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