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Study · Not a test of the peptide alone · 2024

6 results

ROS-responsive charge reversal mesoporous silica nanoparticles as promising drug delivery system for neovascular retinal diseases.

Elbedwehy AM, Wu J, Na HK, Baek A, Jung H, Kwon IH, Lee SW, Kim JH, Lee TG

Journal of controlled release : official journal of the Controlled Release Society17 Jul 2024Cited by 21 (Europe PMC)

PMID39002796 (opens in a new tab)DOI10.1016/j.jconrel.2024.07.022 (opens in a new tab)PepBankPUB-39002796
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone6

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 01AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In an oxygen-induced retinopathy mouse model, the nanoparticle system inhibited retinal neovascularization.

    In plain wordsIn mice with oxygen-induced retinopathy, the nanoparticle system reduced the growth of new blood vessels in the retina.

    Peptide
    Humanin
    Outcome
    DecreaseRetinal neovascularization in OIR model
    Study

    mousen: not reported in source

    Oxygen-induced retinopathy (OIR) model
    Outcome group
    Neuroprotection · Eye

    Source sentences

    Summary
    The inhibition of retinal neovascularization was further validated in an in vivo oxygen-induced retinopathy (OIR) mouse model.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 02LabNot a test of Humanin aloneEx vivo tissueOther

    In bovine eyes ex vivo, Ar-MSNs-TK-PEG with a mean zeta potential of 2 mV were immobilized in the negatively charged vitreous.

    In plain wordsIn lab tests on cow eyes, the nanoparticles stayed fixed in the vitreous gel of the eye.

    Peptide
    Humanin
    Outcome
    Not applicableImmobilization of Ar-MSNs-TK-PEG in vitreous
    Study

    bovinen: not reported in source

    Bovine eyes ex vivo
    Outcome group
    Formulation, delivery and stability · Eye

    Measurements

    zeta potential
    2 mV
    Ar-MSNs-TK-PEG

    Source sentences

    Summary
    Ex vivo experiments using bovine eyes revealed the immobilization of Ar-MSNs-TK-PEG (mean zeta potential: 2 mV) in the negatively charged vitreous.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 03LabNot a test of Humanin aloneIn vitro (cells)Other

    ARPE-19 cells effectively internalized HN-loaded Ar-MSNs-TK and subsequently released the peptide.

    In plain wordsIn cells, retinal epithelial cells took up the nanoparticles and then released the humanin peptide.

    Peptide
    Humanin
    Outcome
    Not applicableCell uptake and peptide release in ARPE-19 cells
    Study

    n: not reported in source

    ARPE-19 cells
    Outcome group
    Formulation, delivery and stability · Eye

    Source sentences

    Summary
    In vitro studies showed that ARPE-19 cells effectively internalize HN-loaded Ar-MSNs-TK, subsequently releasing the peptide, which offered protection against oxidative stress-induced apoptosis, as evidenced by reduced TUNEL and caspase3 activation.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  4. 04LabNot a test of Humanin aloneIn vitro (cells)Other

    In ARPE-19 cells, HN-loaded nanoparticles protected against oxidative stress-induced apoptosis, shown by reduced TUNEL and caspase3 activation.

    In plain wordsIn cells, humanin-loaded nanoparticles protected against cell death from oxidative stress, with less TUNEL staining and caspase3 activation.

    Peptide
    Humanin
    Outcome
    DecreaseProtection against oxidative stress-induced apoptosis (TUNEL, caspase3)
    Study

    n: not reported in source

    ARPE-19 cells
    Outcome group
    Neuroprotection · Eye

    Source sentences

    Summary
    In vitro studies showed that ARPE-19 cells effectively internalize HN-loaded Ar-MSNs-TK, subsequently releasing the peptide, which offered protection against oxidative stress-induced apoptosis, as evidenced by reduced TUNEL and caspase3 activation.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  5. 05LabNot a test of Humanin aloneIn vitro (cell-free)Other

    The mesoporous silica nanoparticle core with a 2.8 nm pore size reached a humanin loading capacity of 64.4% (w/w).

    In plain wordsIn lab tests, the nanoparticle core could hold a large share of humanin peptide by weight.

    Peptide
    Humanin
    Outcome
    Not applicableHN loading capacity of the MSN core
    Study

    n: not reported in source

    Mesoporous silica nanoparticles
    Outcome group
    Formulation, delivery and stability · Pharmacology

    Measurements

    HN loading capacity
    64.4 % (w/w)
    MSN core with 2.8 nm pore size

    Source sentences

    Summary
    The MSN core, designed with a pore size of 2.8 nm, ensures a high HN loading capacity 64.4% (w/w).

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  6. 06LabNot a test of Humanin aloneOther designOther

    Oxidative stress reversed the surface charge of the nanoparticles to -25 mV by mPEG loss, which facilitated diffusion of nanoparticles carrying humanin.

    In plain wordsIn lab tests, oxidative stress flipped the nanoparticle charge to negative, which helped nanoparticles carrying humanin to spread.

    Peptide
    Humanin
    Outcome
    DecreaseSurface charge reversal under oxidative stress
    Study

    n: not reported in source

    Ar-MSNs-TK-PEG nanoparticles
    Outcome group
    Formulation, delivery and stability · Eye

    Measurements

    zeta potential
    −25 mV
    after oxidative stress

    Source sentences

    Summary
    However, oxidative stress reversed the surface charge to -25 mV by mPEG loss, facilitating the diffusion of the nanoparticles impeded with HN.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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