The influence of ghrelin agonist ipamorelin acetate on the hypothalamic-pituitary-testicular axis in a cichlid fish, Oreochromis mossambicus.

Gouda M, Ganesh CB

Animal reproduction science5 Jul 2024Cited by 3 (Europe PMC)

PMID38996787DOI10.1016/j.anireprosci.2024.107550PepBankPUB-38996787

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In tilapia, ipamorelin acetate at 5 or 30 µg for 21 days raised food intake in a dose-dependent way compared with the control group.
In plain wordsIn tilapia, ipamorelin increased food intake with the dose compared with controls.
Peptide
Ipamorelin
Outcome
IncreaseFood intake
Study
Oreochromis mossambicus (tilapia)n: not reported in source
Tilapia in vivo
Comparator
Control
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
5 or 30 µg · 21 daysAs given in this study (Oreochromis mossambicus (tilapia)).
Source sentences
Summary
The administration of either 5 or 30 µg of IPA for 21 days led to a significant and dose-dependent rise in food intake
1 context sentence(design, population, supporting numbers)
Summary · context
The objective of this study was to examine the impact of ipamorelin acetate (IPA), a ghrelin agonist, on the reproductive axis of the tilapia Oreochromis mossambicus.
Report a problemFND-3899678701
02AnimalAnimal study (in vivo)Efficacy outcome
In tilapia, ipamorelin acetate at 5 or 30 µg for 21 days increased the number of primary spermatocytes compared with the control group.
In plain wordsIn tilapia, ipamorelin increased the number of early sperm-forming cells (primary spermatocytes) compared with controls.
Peptide
Ipamorelin
Outcome
IncreasePrimary spermatocyte number
Study
Oreochromis mossambicus (tilapia)n: not reported in source
Tilapia in vivo
Comparator
Control
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
5 or 30 µg · 21 daysAs given in this study (Oreochromis mossambicus (tilapia)).
Source sentences
Summary
The administration of either 5 or 30 µg of IPA for 21 days led to a significant and dose-dependent rise in food intake concomitant with a significant increase in the numbers of primary spermatocytes, secondary spermatocytes, and early spermatids compared to the control group.
1 context sentence(design, population, supporting numbers)
Summary · context
The objective of this study was to examine the impact of ipamorelin acetate (IPA), a ghrelin agonist, on the reproductive axis of the tilapia Oreochromis mossambicus.
Report a problemFND-3899678702
03AnimalAnimal study (in vivo)Efficacy outcome
In tilapia, ipamorelin acetate at 5 or 30 µg for 21 days increased the number of secondary spermatocytes compared with the control group.
In plain wordsIn tilapia, ipamorelin increased the number of secondary spermatocytes, a stage of sperm development, compared with controls.
Peptide
Ipamorelin
Outcome
IncreaseSecondary spermatocyte number
Study
Oreochromis mossambicus (tilapia)n: not reported in source
Tilapia in vivo
Comparator
Control
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
5 or 30 µg · 21 daysAs given in this study (Oreochromis mossambicus (tilapia)).
Source sentences
Summary
The administration of either 5 or 30 µg of IPA for 21 days led to a significant and dose-dependent rise in food intake concomitant with a significant increase in the numbers of primary spermatocytes, secondary spermatocytes, and early spermatids compared to the control group.
1 context sentence(design, population, supporting numbers)
Summary · context
The objective of this study was to examine the impact of ipamorelin acetate (IPA), a ghrelin agonist, on the reproductive axis of the tilapia Oreochromis mossambicus.
Report a problemFND-3899678703
04AnimalAnimal study (in vivo)Efficacy outcome
In tilapia, ipamorelin acetate at 5 or 30 µg for 21 days increased the number of early spermatids compared with the control group.
In plain wordsIn tilapia, ipamorelin increased the number of early spermatids, a stage of sperm development, compared with controls.
Peptide
Ipamorelin
Outcome
IncreaseEarly spermatid number
Study
Oreochromis mossambicus (tilapia)n: not reported in source
Tilapia in vivo
Comparator
Control
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
5 or 30 µg · 21 daysAs given in this study (Oreochromis mossambicus (tilapia)).
Source sentences
Summary
The administration of either 5 or 30 µg of IPA for 21 days led to a significant and dose-dependent rise in food intake concomitant with a significant increase in the numbers of primary spermatocytes, secondary spermatocytes, and early spermatids compared to the control group.
1 context sentence(design, population, supporting numbers)
Summary · context
The objective of this study was to examine the impact of ipamorelin acetate (IPA), a ghrelin agonist, on the reproductive axis of the tilapia Oreochromis mossambicus.
Report a problemFND-3899678704
05AnimalAnimal study (in vivo)Efficacy outcome
In tilapia, ipamorelin acetate at 30 µg increased the number of late spermatids compared with the control group.
In plain wordsIn tilapia, ipamorelin at the higher dose increased the number of late sperm-forming cells compared with controls.
Peptide
Ipamorelin
Outcome
IncreaseLate spermatid number
Study
Oreochromis mossambicus (tilapia)n: not reported in source
Tilapia in vivo
Comparator
Control
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
30 µg · 21 daysAs given in this study (Oreochromis mossambicus (tilapia)).
Source sentences
Summary
There was a significant rise in the number of late spermatids, as well as the areas of the lobule and lumen, in fish treated with 30 µg of IPA, compared to the control group.
1 context sentence(design, population, supporting numbers)
Summary · context
The objective of this study was to examine the impact of ipamorelin acetate (IPA), a ghrelin agonist, on the reproductive axis of the tilapia Oreochromis mossambicus.
Report a problemFND-3899678705
06AnimalAnimal study (in vivo)Efficacy outcome
In tilapia, ipamorelin acetate at 30 µg increased the area of the testis lobule compared with the control group.
In plain wordsIn tilapia, ipamorelin at the higher dose increased the area of the testis lobule compared with controls.
Peptide
Ipamorelin
Outcome
IncreaseTestis lobule area
Study
Oreochromis mossambicus (tilapia)n: not reported in source
Tilapia in vivo
Comparator
Control
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
30 µg · 21 daysAs given in this study (Oreochromis mossambicus (tilapia)).
Source sentences
Summary
There was a significant rise in the number of late spermatids, as well as the areas of the lobule and lumen, in fish treated with 30 µg of IPA, compared to the control group.
1 context sentence(design, population, supporting numbers)
Summary · context
The objective of this study was to examine the impact of ipamorelin acetate (IPA), a ghrelin agonist, on the reproductive axis of the tilapia Oreochromis mossambicus.
Report a problemFND-3899678706
07AnimalAnimal study (in vivo)Efficacy outcome
In tilapia, ipamorelin acetate at 30 µg increased the area of the lumen compared with the control group.
In plain wordsIn tilapia, ipamorelin at the higher dose increased the area of the lumen in the testis compared with controls.
Peptide
Ipamorelin
Outcome
IncreaseTestis lumen area
Study
Oreochromis mossambicus (tilapia)n: not reported in source
Tilapia in vivo
Comparator
Control
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
30 µg · 21 daysAs given in this study (Oreochromis mossambicus (tilapia)).
Source sentences
Summary
There was a significant rise in the number of late spermatids, as well as the areas of the lobule and lumen, in fish treated with 30 µg of IPA, compared to the control group.
1 context sentence(design, population, supporting numbers)
Summary · context
The objective of this study was to examine the impact of ipamorelin acetate (IPA), a ghrelin agonist, on the reproductive axis of the tilapia Oreochromis mossambicus.
Report a problemFND-3899678707
08AnimalAnimal study (in vivo)Mechanism
In tilapia treated with ipamorelin acetate, the percentage of GnRH-immunoreactive fibres in the hypothalamus did not differ significantly across groups.
In plain wordsIn tilapia, ipamorelin did not significantly change the share of GnRH nerve fibres in the hypothalamus.
Peptide
Ipamorelin
Outcome
No significant changeGnRH-immunoreactive fibres in hypothalamus
Study
Oreochromis mossambicus (tilapia)n: not reported in source
Tilapia in vivo
Comparator
Control
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
5 or 30 µg · 21 daysAs given in this study (Oreochromis mossambicus (tilapia)).
Source sentences
Summary
Moreover, there was no significant difference in the percentage of gonadotropin-releasing hormone (GnRH)-immunoreactive fibres in the hypothalamus and anterior pituitary gland across different groups.
1 context sentence(design, population, supporting numbers)
Summary · context
The objective of this study was to examine the impact of ipamorelin acetate (IPA), a ghrelin agonist, on the reproductive axis of the tilapia Oreochromis mossambicus.
Report a problemFND-3899678708
09AnimalAnimal study (in vivo)Mechanism
In tilapia treated with ipamorelin acetate, the percentage of GnRH-immunoreactive fibres in the anterior pituitary gland did not differ significantly across groups.
In plain wordsIn tilapia, ipamorelin did not significantly change the share of GnRH nerve fibres in the anterior pituitary gland.
Peptide
Ipamorelin
Outcome
No significant changeGnRH-immunoreactive fibres in anterior pituitary
Study
Oreochromis mossambicus (tilapia)n: not reported in source
Tilapia in vivo
Comparator
Control
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
5 or 30 µg · 21 daysAs given in this study (Oreochromis mossambicus (tilapia)).
Source sentences
Summary
Moreover, there was no significant difference in the percentage of gonadotropin-releasing hormone (GnRH)-immunoreactive fibres in the hypothalamus and anterior pituitary gland across different groups.
1 context sentence(design, population, supporting numbers)
Summary · context
The objective of this study was to examine the impact of ipamorelin acetate (IPA), a ghrelin agonist, on the reproductive axis of the tilapia Oreochromis mossambicus.
Report a problemFND-3899678709
10AnimalAnimal study (in vivo)Mechanism
In tilapia, ipamorelin acetate at 30 µg raised the expression of androgen receptor protein.
In plain wordsIn tilapia, ipamorelin at the higher dose raised the level of androgen receptor protein.
Peptide
Ipamorelin
Outcome
IncreaseAndrogen receptor protein expression
Study
Oreochromis mossambicus (tilapia)n: not reported in source
Tilapia in vivo
Comparator
Control
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
30 µg · 21 daysAs given in this study (Oreochromis mossambicus (tilapia)).
Source sentences
Summary
However, a significant elevation in the expression of androgen receptor protein was observed in fish treated with 30 µg of IPA.
1 context sentence(design, population, supporting numbers)
Summary · context
The objective of this study was to examine the impact of ipamorelin acetate (IPA), a ghrelin agonist, on the reproductive axis of the tilapia Oreochromis mossambicus.
Report a problemFND-3899678710
11AnimalAnimal study (in vivo)Mechanism
In tilapia, ipamorelin acetate at 5 or 30 µg raised serum luteinizing hormone concentrations compared with the control group.
In plain wordsIn tilapia, ipamorelin raised blood levels of luteinizing hormone compared with controls.
Peptide
Ipamorelin
Outcome
IncreaseSerum luteinizing hormone
Study
Oreochromis mossambicus (tilapia)n: not reported in source
Tilapia in vivo
Comparator
Control
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
5 or 30 µg · 21 daysAs given in this study (Oreochromis mossambicus (tilapia)).
Source sentences
Summary
Furthermore, the concentrations of luteinizing hormone (LH) and 11-ketotestosterone (11-KT) in the serum of fish treated with either 5 or 30 µg of IPA were significantly elevated in comparison to the control group.
1 context sentence(design, population, supporting numbers)
Summary · context
The objective of this study was to examine the impact of ipamorelin acetate (IPA), a ghrelin agonist, on the reproductive axis of the tilapia Oreochromis mossambicus.
Report a problemFND-3899678711
12AnimalAnimal study (in vivo)Mechanism
In tilapia, ipamorelin acetate at 5 or 30 µg raised serum 11-ketotestosterone concentrations compared with the control group.
In plain wordsIn tilapia, ipamorelin raised blood levels of the sex hormone 11-ketotestosterone compared with controls.
Peptide
Ipamorelin
Outcome
IncreaseSerum 11-ketotestosterone
Study
Oreochromis mossambicus (tilapia)n: not reported in source
Tilapia in vivo
Comparator
Control
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
5 or 30 µg · 21 daysAs given in this study (Oreochromis mossambicus (tilapia)).
Source sentences
Summary
Furthermore, the concentrations of luteinizing hormone (LH) and 11-ketotestosterone (11-KT) in the serum of fish treated with either 5 or 30 µg of IPA were significantly elevated in comparison to the control group.
1 context sentence(design, population, supporting numbers)
Summary · context
The objective of this study was to examine the impact of ipamorelin acetate (IPA), a ghrelin agonist, on the reproductive axis of the tilapia Oreochromis mossambicus.
Report a problemFND-3899678712

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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