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Study · Not a test of the peptide alone · 2024

4 results

Investigating the detection of the novel doping‐relevant peptide kisspeptin‐10 in urine using liquid chromatography high‐resolution mass spectrometry.

Colpaert T, Risseeuw M, Deventer K, Van Eenoo P

Biomedical chromatography : BMC8 Jul 2024Cited by 5 (Europe PMC)

PMID38978171 (opens in a new tab)DOI10.1002/bmc.5946 (opens in a new tab)PepBankPUB-38978171
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 01LabNot a test of Kisspeptin-10 aloneIn vitro (cell-free)Other

    A screening procedure and a confirmation procedure for kisspeptin‑10 in urine by liquid chromatography-mass spectrometry were successfully validated.

    In plain wordsIn lab tests, two urine methods for detecting kisspeptin‑10 were validated.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableValidation of screening and confirmation procedures in urine
    Study

    n: not reported in source

    Urine and human serum, LC-MS
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    This work describes the successful validation of an initial testing procedure (screening) and a confirmation procedure for kisspeptin-10 in urine using liquid chromatography-mass spectrometry.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  2. 02LabNot a test of Kisspeptin-10 aloneIn vitro (cell-free)Other

    After incubation of kisspeptin‑10 in human serum, four metabolites (peptide fragments y9, y8, y7 and y5) were found.

    In plain wordsIn lab tests, kisspeptin‑10 broke down into four fragments in human serum.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableMetabolites after incubation in human serum
    Study

    n: not reported in source

    Urine and human serum, LC-MS
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    Additionally, kisspeptin-10 was incubated in human serum to mimic endogenous metabolism to improve method sensitivity, as previous research had demonstrated a rapid elimination time of only 30 min after injection (in rats). Four metabolites, corresponding to peptide fragments y9, y8, y7 and y5, were…

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  3. 03LabNot a test of Kisspeptin-10 aloneIn vitro (cell-free)Other

    A degradation product of kisspeptin‑10 was probably caused by oxidation of the tryptophan residue into a kynurenine residue.

    In plain wordsIn lab tests, kisspeptin‑10 probably degraded when one of its building blocks was oxidised.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableDegradation product from tryptophan oxidation
    Study

    n: not reported in source

    Urine and human serum, LC-MS
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    A degradation product discovered during early experimentation was found to probably be caused by oxidation of the tryptophan residue into a kynurenine residue.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  4. 04LabNot a test of Kisspeptin-10 aloneIn vitro (cell-free)Other

    A black-market vial of kisspeptin‑10 contained no unexpected impurities but appeared more degraded than the purchased reference standard.

    In plain wordsIn lab tests, a black-market kisspeptin‑10 vial had no unexpected impurities but looked more degraded than the reference standard.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableAnalysis of a black-market vial of kisspeptin-10
    Study

    n: not reported in source

    Urine and human serum, LC-MS
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    Using the validated confirmation procedure, a black-market vial of kisspeptin-10 was analysed. The product contained no unexpected impurities, although it appeared to have undergone more degradation than the purchased reference standard.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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