[Notch1/Akt/Foxo1 Pathway Regulated by Kisspeptin Is Involved in Endometrial Decidualization in Patients With Recurrent Spontaneous Abortion].

Yang Y, Zhang J, Li D, Liu C, Guo R, Xiao Y, Zhou L, Tong L, Zhang H

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition1 May 2024Cited by 1 (Europe PMC)

PMID38948287PMCIDPMC11211770DOI10.12182/20240560206PepBankPUB-38948287

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study9

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In mice with recurrent spontaneous abortion, kisspeptin10 decreased fetal absorption rates compared with saline.
In plain wordsIn mice with recurrent miscarriage, kisspeptin10 caused less embryo loss than saline.
Peptide
Kisspeptin-10
Outcome
DecreaseFetal absorption rate after kisspeptin10
Study
mousen = 6
RSA model (CBA/J x DBA/2) mice
Comparator
Normal saline
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · intraperitonealAs given in this study (mouse).
Source sentences
Summary
Conversely, RSA mice administered with kisspeptin10 demonstrated decreased fetal absorption rates (P<0.001)
1 context sentence(design, population, supporting numbers)
Summary · context
The experimental groups received intraperitoneal injections of kisspeptin10 and kisspeptin234 (acting as a blocker) and were designated as RSA-KP10 and NP-KP234 groups.
Report a problemFND-3894828708
02AnimalAnimal study (in vivo)Mechanism
In mice with recurrent spontaneous abortion, kisspeptin10 increased the expression of IGFBP1, Notch1, Akt and Foxo1 compared with saline.
In plain wordsIn mice with recurrent miscarriage, kisspeptin10 raised the levels of four proteins compared with saline.
Peptide
Kisspeptin-10
Outcome
IncreaseIGFBP1, Notch1, Akt and Foxo1 expression after kisspeptin10
Study
mousen = 6
RSA model (CBA/J x DBA/2) mice
Comparator
Normal saline
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · intraperitonealAs given in this study (mouse).
Source sentences
Summary
Conversely, RSA mice administered with kisspeptin10 demonstrated decreased fetal absorption rates (PP<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
The experimental groups received intraperitoneal injections of kisspeptin10 and kisspeptin234 (acting as a blocker) and were designated as RSA-KP10 and NP-KP234 groups.
Report a problemFND-3894828709
03LabIn vitro (cells)Mechanism
In human endometrial stromal cells, kisspeptin10 enhanced decidualization capability.
In plain wordsIn cells from the uterine lining, kisspeptin10 improved their ability to change for pregnancy.
Peptide
Kisspeptin-10
Outcome
IncreaseDecidualization capability after kisspeptin10
Study
humann: not reported in source
Human endometrial stromal cells (hESC)
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
After the introduction of kisspeptin10 to hESC, there was an observed enhancement in decidualization capability.
1 context sentence(design, population, supporting numbers)
Summary · context
Human endometrial stromal cells (hESC) were given targeted interventions, including treatment with siRNA to disrupt KISS1 or exposure to kisspeptin10 (the bioactive fragment of kisspeptin), and were subsequently designated as the siKP group or the KP10 group, respectively.
Report a problemFND-3894828702
04LabIn vitro (cells)Mechanism
In human endometrial stromal cells, kisspeptin10 increased the expression of Notch1, Akt and Foxo1.
In plain wordsIn cells from the uterine lining, kisspeptin10 raised the levels of three signalling proteins.
Peptide
Kisspeptin-10
Outcome
IncreaseNotch1, Akt and Foxo1 expression after kisspeptin10
Study
humann: not reported in source
Human endometrial stromal cells (hESC)
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
the expression levels of Notch1, Akt, and Foxo1 showed an increase
1 context sentence(design, population, supporting numbers)
Summary · context
Human endometrial stromal cells (hESC) were given targeted interventions, including treatment with siRNA to disrupt KISS1 or exposure to kisspeptin10 (the bioactive fragment of kisspeptin), and were subsequently designated as the siKP group or the KP10 group, respectively.
Report a problemFND-3894828703
05LabIn vitro (cells)Mechanism
In human endometrial stromal cells, kisspeptin10 increased Notch1 expression on immunofluorescence, in line with enhanced decidualization.
In plain wordsIn cells from the uterine lining, kisspeptin10 raised the level of the signalling protein Notch1.
Peptide
Kisspeptin-10
Outcome
IncreaseNotch1 expression by immunofluorescence after kisspeptin10
Study
humann: not reported in source
Human endometrial stromal cells (hESC)
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Concurrently, the expression of Notch1 increased, suggesting enhanced decidualization upon the administration of kisspeptin10
1 context sentence(design, population, supporting numbers)
Summary · context
Human endometrial stromal cells (hESC) were given targeted interventions, including treatment with siRNA to disrupt KISS1 or exposure to kisspeptin10 (the bioactive fragment of kisspeptin), and were subsequently designated as the siKP group or the KP10 group, respectively.
Report a problemFND-3894828704

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

06HumanEndogenous levelObservational studyOther
In decidua, kisspeptin expression was significantly lower in women with recurrent spontaneous abortion than in women with normal pregnancy.
In plain wordsWomen with recurrent miscarriage had lower levels of the body's own kisspeptin in the uterine lining than women with normal pregnancy.
Peptide
Kisspeptin-10
Outcome
DecreaseDecidual kisspeptin expression in recurrent spontaneous abortion
Study
n = 95
Comparator
Women with normal pregnancy
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
The analysis revealed that the expression levels of kisspeptin, IGFBP1, Notch1, Akt, and Foxo1 were significantly lower in patients diagnosed with RSA compared to those in women with NP
2 context sentences(design, population, supporting numbers)
Summary · context
(PP<0.05 for IGFBP1, Notch1, Akt, and Foxo1).
Summary · context
We enrolled a cohort comprising 45 individuals diagnosed with RSA, who were admitted to the outpatient clinic of the Reproductive Center at the Second Affiliated Hospital of Soochow University between June 2020 and December 2020.
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3894828701

Studies that did not test the peptide alone3

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

07AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Efficacy outcome
In mice with normal pregnancy, the kisspeptin blocker kisspeptin234 increased fetal absorption rates compared with saline.
In plain wordsIn mice with normal pregnancy, a drug that blocks kisspeptin caused more embryo loss than saline.
Peptide
Kisspeptin-10
Outcome
IncreaseFetal absorption rate after kisspeptin234 blocker
Study
mousen = 6
Normal pregnancy (CBA/J x BALB/c) mice
Comparator
Normal saline
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
In comparison to the NS group, NP mice administered with kisspeptin234 exhibited increased fetal absorption rates (P<0.001)
1 context sentence(design, population, supporting numbers)
Summary · context
The experimental groups received intraperitoneal injections of kisspeptin10 and kisspeptin234 (acting as a blocker) and were designated as RSA-KP10 and NP-KP234 groups.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-3894828706
08AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Mechanism
In mice with normal pregnancy, the kisspeptin blocker kisspeptin234 decreased the expression of IGFBP1, Notch1, Akt and Foxo1 compared with saline.
In plain wordsIn mice with normal pregnancy, a drug that blocks kisspeptin lowered the levels of four proteins compared with saline.
Peptide
Kisspeptin-10
Outcome
DecreaseIGFBP1, Notch1, Akt and Foxo1 expression after kisspeptin234 blocker
Study
mousen = 6
Normal pregnancy (CBA/J x BALB/c) mice
Comparator
Normal saline
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
In comparison to the NS group, NP mice administered with kisspeptin234 exhibited increased fetal absorption rates (PP<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
The experimental groups received intraperitoneal injections of kisspeptin10 and kisspeptin234 (acting as a blocker) and were designated as RSA-KP10 and NP-KP234 groups.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-3894828707
09LabNot a test of Kisspeptin-10 aloneIn vitro (cells)Mechanism
In human endometrial stromal cells, siRNA interference with KISS1 decreased the expression of Notch1, Akt and Foxo1.
In plain wordsIn cells from the uterine lining, switching off the kisspeptin gene lowered the levels of three signalling proteins.
Peptide
Kisspeptin-10
Outcome
DecreaseNotch1, Akt and Foxo1 expression after KISS1 interference
Study
humann: not reported in source
Human endometrial stromal cells (hESC)
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
but they decreased after interference with KISS1.
1 context sentence(design, population, supporting numbers)
Summary · context
Human endometrial stromal cells (hESC) were given targeted interventions, including treatment with siRNA to disrupt KISS1 or exposure to kisspeptin10 (the bioactive fragment of kisspeptin), and were subsequently designated as the siKP group or the KP10 group, respectively.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-3894828705

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 17:28 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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