Identification of adrenergic presynaptic and postsynaptic protein locations at neuromuscular junctions, their decrease during aging, and recovery by nicotinamide mononucleotide administration.

Takeno K, Watanabe N, Morifuji M, Hotta H, Nishimune H

Neuroreport27 Jun 2024Cited by 3 (Europe PMC)

PMID38935067DOI10.1097/wnr.0000000000002070PepBankPUB-38935067

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In aged mice, NMN restored neuromuscular junction vesicular monoamine transporter 2 signal intensity to adult levels.
In plain wordsIn mice, NMN restored an age-reduced presynaptic protein signal to adult levels.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseVesicular monoamine transporter 2 signal
Study
mousen: not reported in source
aged mice
Comparator
adult mice and aged mice without NMN
Outcome group
Receptor activity and mechanism · Musculoskeletal
Studied dose
Dose not stated · oral in drinking water · 1 monthAs given in this study (mouse).
Source sentences
Summary
Interestingly, both age-related declines reverted to the adult level after 1 month of oral administration of NMN by drinking water.
2 context sentences(design, population, supporting numbers)
Summary · context
However, the signal intensity of vesicular monoamine transporter 2 and β2-adrenergic receptors showed age-related decline at neuromuscular junctions.
Summary · context
Sympathetic nerves, presynaptic, and postsynaptic proteins of sympathetic nerves at neuromuscular junctions were visualized using immunohistochemistry, and aging-related changes were compared between adult-, aged-, and nicotinamide mononucleotide (NMN) administered aged mice.
Report a problemFND-3893506701
02AnimalAnimal study (in vivo)Mechanism
In aged mice, NMN restored neuromuscular junction β2-adrenergic receptor signal intensity to adult levels.
In plain wordsIn mice, NMN restored an age-reduced adrenergic receptor signal to adult levels.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
Increaseβ2-adrenergic receptor signal
Study
mousen: not reported in source
aged mice
Comparator
adult mice and aged mice without NMN
Outcome group
Receptor activity and mechanism · Musculoskeletal
Studied dose
Dose not stated · oral in drinking water · 1 monthAs given in this study (mouse).
Source sentences
Summary
Interestingly, both age-related declines reverted to the adult level after 1 month of oral administration of NMN by drinking water.
2 context sentences(design, population, supporting numbers)
Summary · context
However, the signal intensity of vesicular monoamine transporter 2 and β2-adrenergic receptors showed age-related decline at neuromuscular junctions.
Summary · context
Sympathetic nerves, presynaptic, and postsynaptic proteins of sympathetic nerves at neuromuscular junctions were visualized using immunohistochemistry, and aging-related changes were compared between adult-, aged-, and nicotinamide mononucleotide (NMN) administered aged mice.
Report a problemFND-3893506702
03AnimalAnimal study (in vivo)Mechanism
In aged mice, NMN did not alter tyrosine hydroxylase expression at neuromuscular junctions.
In plain wordsIn mice, NMN did not change tyrosine hydroxylase expression at nerve-muscle junctions.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
No significant changeTyrosine hydroxylase expression
Study
mousen: not reported in source
aged mice
Outcome group
Receptor activity and mechanism · Musculoskeletal
Studied dose
Dose not stated · oral in drinking water · 1 monthAs given in this study (mouse).
Source sentences
Summary
In contrast, NMN administration did not alter the expression level of sympathetic marker tyrosine hydroxylase at neuromuscular junctions.
1 context sentence(design, population, supporting numbers)
Summary · context
Sympathetic nerves, presynaptic, and postsynaptic proteins of sympathetic nerves at neuromuscular junctions were visualized using immunohistochemistry, and aging-related changes were compared between adult-, aged-, and nicotinamide mononucleotide (NMN) administered aged mice.
Report a problemFND-3893506703

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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