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Study · Systematic review · n = 2,463 · 2024

7 results

Liraglutide's Effect on Weight Management in Subjects With Pre-diabetes: A Systematic Review & Meta-Analysis.

Alsanea S, Alkofide H, Almadi B, Almohammed O, Alwhaibi A, Alrabiah Z, Kalagi N

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists21 May 2024Cited by 3 (Europe PMC)

PMID38782201 (opens in a new tab)DOI10.1016/j.eprac.2024.05.009 (opens in a new tab)PepBankPUB-38782201
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

  1. 01HumanSystematic reviewEfficacy outcome

    In people with prediabetes, pooled liraglutide trials showed a mean body weight difference of -4.95 kg versus control.

    In plain wordsIn people with prediabetes, liraglutide led to lower body weight than control across pooled trials.

    Peptide
    Liraglutide
    Outcome
    DecreaseBody weight
    Study

    n = 2,463

    Comparator
    Control arm
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Measurements

    Mean difference
    −4.95 kg
    body weight

    Source sentences

    Summary
    Participants exposed to liraglutide showed a decrease in body weight (mean difference [MD] = -4.95 kg; 95% CI -5.16, -4.73; I2 = 93%)
    2 context sentences
    Summary · context
    A systematic literature search was conducted across MEDLINE, Embase, ClinicalTrials.gov, and the reference list of retrieved studies to identify eligible English language randomized controlled trials evaluating liraglutide's effect on weight in individuals with pre-diabetes.
    Summary · context
    Five eligible studies were included, with a total of 1604 subjects in the liraglutide arm and 859 subjects in the control arm.
  2. 02HumanSystematic reviewEfficacy outcome

    In people with prediabetes, pooled liraglutide trials showed a mean BMI difference of -2.06 kg/m2 versus control.

    In plain wordsIn people with prediabetes, liraglutide led to lower BMI than control across pooled trials.

    Peptide
    Liraglutide
    Outcome
    DecreaseBody mass index
    Study

    n = 2,463

    Comparator
    Control arm
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Measurements

    Mean difference
    −2.06 kg/m<sup>2</sup>
    BMI

    Source sentences

    Summary
    BMI (MD = -2.06 kg/m2; 95%CI -2.22, -1.89; I2 = 97%)
    2 context sentences
    Summary · context
    A systematic literature search was conducted across MEDLINE, Embase, ClinicalTrials.gov, and the reference list of retrieved studies to identify eligible English language randomized controlled trials evaluating liraglutide's effect on weight in individuals with pre-diabetes.
    Summary · context
    Five eligible studies were included, with a total of 1604 subjects in the liraglutide arm and 859 subjects in the control arm.
  3. 03HumanSystematic reviewEfficacy outcome

    In people with prediabetes, pooled liraglutide trials showed a mean waist circumference difference of -4.61 cm versus control.

    In plain wordsIn people with prediabetes, liraglutide led to a smaller waist than control across pooled trials.

    Peptide
    Liraglutide
    Outcome
    DecreaseWaist circumference
    Study

    n = 2,463

    Comparator
    Control arm
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Measurements

    Mean difference
    −4.61 cm
    waist circumference

    Source sentences

    Summary
    waist circumference (MD = -4.61 cm; 95% CI -4.79, -4.43; I2 = 82%)
    2 context sentences
    Summary · context
    A systematic literature search was conducted across MEDLINE, Embase, ClinicalTrials.gov, and the reference list of retrieved studies to identify eligible English language randomized controlled trials evaluating liraglutide's effect on weight in individuals with pre-diabetes.
    Summary · context
    Five eligible studies were included, with a total of 1604 subjects in the liraglutide arm and 859 subjects in the control arm.
  4. 04HumanSystematic reviewEfficacy outcome

    In people with prediabetes, pooled liraglutide trials showed a mean HbA1c difference of -0.33% versus control.

    In plain wordsIn people with prediabetes, liraglutide led to lower HbA1c than control across pooled trials.

    Peptide
    Liraglutide
    Outcome
    DecreaseHbA1c
    Study

    n = 2,463

    Comparator
    Control arm
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Measurements

    Mean difference
    −0.33%
    HbA1c

    Source sentences

    Summary
    HbA1c (MD = -0.33%; 95%CI -0.34, -0.31; I2 = 100%)
    2 context sentences
    Summary · context
    A systematic literature search was conducted across MEDLINE, Embase, ClinicalTrials.gov, and the reference list of retrieved studies to identify eligible English language randomized controlled trials evaluating liraglutide's effect on weight in individuals with pre-diabetes.
    Summary · context
    Five eligible studies were included, with a total of 1604 subjects in the liraglutide arm and 859 subjects in the control arm.
  5. 05HumanSystematic reviewEfficacy outcome

    In people with prediabetes, pooled liraglutide trials showed a mean LDL cholesterol difference of -0.36 mmol/L versus control.

    In plain wordsIn people with prediabetes, liraglutide led to lower LDL cholesterol than control across pooled trials.

    Peptide
    Liraglutide
    Outcome
    DecreaseLDL cholesterol
    Study

    n = 2,463

    Comparator
    Control arm
    Outcome group
    Lipids · Cardiovascular
    Studied dose
    Dose not stated

    Measurements

    Mean difference
    −0.36 mmol/L
    LDL cholesterol

    Source sentences

    Summary
    low-density lipoprotein cholesterol levels (MD = -0.36 mmol/L; 95% CI -0.39, -0.33; I2 = 99%)
    2 context sentences
    Summary · context
    A systematic literature search was conducted across MEDLINE, Embase, ClinicalTrials.gov, and the reference list of retrieved studies to identify eligible English language randomized controlled trials evaluating liraglutide's effect on weight in individuals with pre-diabetes.
    Summary · context
    Five eligible studies were included, with a total of 1604 subjects in the liraglutide arm and 859 subjects in the control arm.
  6. 06HumanSystematic reviewSafety outcome

    In people with prediabetes, the rate of adverse events was higher with liraglutide than with control in the pooled trials.

    In plain wordsIn people with prediabetes, side effects were more common with liraglutide than with control.

    Peptide
    Liraglutide
    Outcome
    IncreaseAdverse event rate
    Study

    n = 2,463

    Comparator
    Control arm
    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    the rate of adverse events was higher with liraglutide when compared to the control
    2 context sentences
    Summary · context
    A systematic literature search was conducted across MEDLINE, Embase, ClinicalTrials.gov, and the reference list of retrieved studies to identify eligible English language randomized controlled trials evaluating liraglutide's effect on weight in individuals with pre-diabetes.
    Summary · context
    Five eligible studies were included, with a total of 1604 subjects in the liraglutide arm and 859 subjects in the control arm.
  7. 07HumanSystematic reviewSafety outcome

    In people with prediabetes, dropout rates were relatively lower in the liraglutide arm than in the control arm.

    In plain wordsIn people with prediabetes, fewer people dropped out of the liraglutide arm than the control arm.

    Peptide
    Liraglutide
    Outcome
    DecreaseDropout rate
    Study

    n = 2,463

    Comparator
    Control arm
    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    the dropout rates were relatively lower in the former arm.
    2 context sentences
    Summary · context
    A systematic literature search was conducted across MEDLINE, Embase, ClinicalTrials.gov, and the reference list of retrieved studies to identify eligible English language randomized controlled trials evaluating liraglutide's effect on weight in individuals with pre-diabetes.
    Summary · context
    Five eligible studies were included, with a total of 1604 subjects in the liraglutide arm and 859 subjects in the control arm.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 11:11 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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