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Study · Measured the body's own peptide · 2024

2 results

The subcommissural organ regulates brain development via secreted peptides.

Zhang T, Ai D, Wei P, Xu Y, Bi Z, Ma F, Li F, Chen XJ, Zhang Z, Zou X, Guo Z, Zhao Y and 20 more

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Li JL, Ye M, Feng Z, Zhang X, Zheng L, Yu J, Li C, Tu T, Zeng H, Lei J, Zhang H, Hong T, Zhang L, Luo B, Li Z, Xing C, Jia C, Li L, Sun W, Ge WP

Nature neuroscience13 May 2024Cited by 11 (Europe PMC)

PMID38741020 (opens in a new tab)DOI10.1038/s41593-024-01639-x (opens in a new tab)PepBankPUB-38741020
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In mice, peptidomic analysis found the body's own thymosin beta‑4 enriched among subcommissural organ-derived peptides.

    In plain wordsIn mice, the body's own thymosin beta‑4 was enriched in a brain gland called the subcommissural organ.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseEnrichment of Tβ4 in SCO peptidome
    Study

    mousen: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Unbiased peptidomic analysis revealed enrichment of three SCO-derived peptides, namely, thymosin beta 4, thymosin beta 10 and NP24
    1 context sentence
    Summary · context
    Mouse strains expressing Cre recombinase from endogenous promoter/enhancer elements of these genes were used to genetically ablate SCO cells during embryonic development, resulting in severe hydrocephalus and defects in neuronal migration and development of neuronal axons and dendrites.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone1

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 02AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In SCO-ablated mouse brain ventricles, reintroduction of a mix of thymosin beta‑4, thymosin beta 10 and NP24 substantially rescued developmental defects.

    In plain wordsIn mice, putting back a mix of three peptides, including thymosin beta‑4, largely rescued brain development defects.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseRescue of developmental defects by reintroduced SCO peptides
    Study

    mousen: not reported in source

    SCO-ablated mouse embryonic brain
    Comparator
    SCO-ablated brains without peptides
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    namely, thymosin beta 4, thymosin beta 10 and NP24, and their reintroduction into SCO-ablated brain ventricles substantially rescued developmental defects
    1 context sentence
    Summary · context
    Mouse strains expressing Cre recombinase from endogenous promoter/enhancer elements of these genes were used to genetically ablate SCO cells during embryonic development, resulting in severe hydrocephalus and defects in neuronal migration and development of neuronal axons and dendrites.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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