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Study · Ex vivo tissue · mouse · 2023

2 results

Thymosin beta-4 - A potential tool in healing middle ear lesions in adult mammals.

Bako P, Lippai B, Nagy J, Kramer S, Kaszas B, Tornoczki T, Bock-Marquette I

International immunopharmacology14 Feb 2023Cited by 1 (Europe PMC)

PMID38706788 (opens in a new tab)PMCIDPMC11068331 (opens in a new tab)DOI10.1016/j.intimp.2023.109830 (opens in a new tab)PepBankPUB-38706788
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In mouse tympanic membrane tissue, TB4 affected the behavior of epidermal and epithelial cells in vitro, with migration and proliferation measured against PBS.

    In plain wordsIn lab tests on mouse eardrum tissue, TB4 changed how eardrum skin cells behaved. The abstract does not state the direction.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Direction not reportedTympanic membrane cell migration and proliferation
    Study

    mousen: not reported in source

    Adult mouse tympanic membrane explants and collagen gel cultures
    Comparator
    PBS
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We discovered the peptide affects the behavior of epidermal and epithelial cells of the tympanic membrane in vitro.
    1 context sentence
    Summary · context
    We harvested tympanic membranes from adult mice and treated these with TB4 or PBS on both collagen gel matrixes and in the form of floating, ex vivo explants.
  2. 02LabEx vivo tissueMechanism

    In mouse tympanic membrane tissue, initial results imply that local epidermal progenitor cells, not differentiated cells, are the primary targets of TB4.

    In plain wordsIn lab tests on mouse eardrum tissue, early results suggest TB4 acts mainly on local progenitor cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableTarget cells of TB4
    Study

    mousen: not reported in source

    Adult mouse tympanic membrane explants and collagen gel cultures
    Comparator
    PBS
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, as our initial results imply, it is not the differentiated, yet most likely the local epidermal progenitor cells which are the primary targets of the molecule.
    1 context sentence
    Summary · context
    We harvested tympanic membranes from adult mice and treated these with TB4 or PBS on both collagen gel matrixes and in the form of floating, ex vivo explants.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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