Mitochondrial dysfunction is associated with cognitive impairment in adults with OSA without dementia.

Li M, Shen T, Yao R, Sun H, Liu X, Li Z, Zhang J

Sleep medicine25 Apr 2024Cited by 5 (Europe PMC)

PMID38704871DOI10.1016/j.sleep.2024.04.035PepBankPUB-38704871

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study14

No result from this study comes from a test of the peptide.

Natural levels measured14

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyOther
Impaired cognitive performance was associated with higher neuron-derived exosome humanin levels.
In plain wordsWorse thinking test performance was linked to higher natural humanin levels in brain-cell exosomes.
Peptide
Humanin
Outcome
IncreaseAssociation of exosome humanin with impaired cognitive performance
Study
n = 268
Outcome group
Endogenous peptide levels · Nervous system and cognition
Measurements
Beta
0.505
humanin
Source sentences
Summary
The impaired cognitive performance was associated with higher NDE levels of humanin (β: 0.505, SE: 0.048, P < 0.001
2 context sentences(design, population, supporting numbers)
Summary · context
Analyses were conducted in 268 study participants with complete polysomnography data, cognitive tests, and important clinical data available.
Summary · context
NDEs were isolated immunochemically for enzyme-linked immunosorbent assay quantification of mitochondrial proteins, i.e., humanin and mitochondrial open reading frame of the 12S rRNA-c (MOTS-c), and synaptic protein, i.e., neurogranin (NRGN).
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3870487111
02HumanEndogenous levelObservational studyMechanism
The relationship between sleep parameters and MoCA scores was mediated by exosome levels of humanin, MOTS-c and NRGN, with 35.33 % to 149.07 % mediation across the three.
In plain wordsThe body's own humanin in brain-cell exosomes, with two other markers, partly explained the link between low oxygen in sleep and worse thinking test scores.
Peptide
Humanin
Outcome
Not applicableMediation of sleep parameters and MoCA by exosome humanin
Study
n = 268
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
The relationship between sleep parameters (mean SaO₂ and T90) and MoCA scores was mediated by the NDE levels of humanin, MOTS-c, and NRGN with the proportion of mediation varying from 35.33 % to 149.07 %.
2 context sentences(design, population, supporting numbers)
Summary · context
Analyses were conducted in 268 study participants with complete polysomnography data, cognitive tests, and important clinical data available.
Summary · context
NDEs were isolated immunochemically for enzyme-linked immunosorbent assay quantification of mitochondrial proteins, i.e., humanin and mitochondrial open reading frame of the 12S rRNA-c (MOTS-c), and synaptic protein, i.e., neurogranin (NRGN).
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3870487112
03HumanEndogenous levelObservational studyOther
In patients with moderate to severe OSA, neuron-derived exosome MOTS‑c levels decreased after one year of CPAP treatment.
In plain wordsIn people with sleep apnea, the body's own MOTS‑c in brain-derived particles fell after one year of CPAP treatment.
Peptide
MOTS-c
Outcome
DecreaseNDE MOTS-c after CPAP treatment
Study
n = 22
Comparator
Baseline
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
Increased humanin, MOTS-c, and NRGN levels significantly decreased after CPAP treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
Twenty-two patients with moderate to severe OSA who received CPAP therapy were followed up, and humanin, MOTS-c and NRGN levels were reassessed after 1 year of treatment.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3870487107
04HumanEndogenous levelObservational studyOther
In patients with moderate to severe OSA, increased exosome humanin levels fell significantly after 1 year of CPAP treatment.
In plain wordsIn sleep apnea patients, raised natural humanin levels in brain-cell exosomes fell after CPAP treatment.
Peptide
Humanin
Outcome
DecreaseExosome humanin after CPAP treatment
Study
n = 22
Comparator
Baseline before CPAP
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
Increased humanin, MOTS-c, and NRGN levels significantly decreased after CPAP treatment.
3 context sentences(design, population, supporting numbers)
Summary · context
Twenty-two patients with moderate to severe OSA who received CPAP therapy were followed up, and humanin, MOTS-c and NRGN levels were reassessed after 1 year of treatment.
Summary · context
Analyses were conducted in 268 study participants with complete polysomnography data, cognitive tests, and important clinical data available.
Summary · context
NDEs were isolated immunochemically for enzyme-linked immunosorbent assay quantification of mitochondrial proteins, i.e., humanin and mitochondrial open reading frame of the 12S rRNA-c (MOTS-c), and synaptic protein, i.e., neurogranin (NRGN).
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3870487114
05HumanEndogenous levelObservational studyOther
In adults with obstructive sleep apnea and mild cognitive impairment, neuron-derived exosome MOTS‑c levels were higher than in the OSA without MCI and control groups.
In plain wordsIn people with sleep apnea and mild cognitive impairment, the body's own MOTS‑c in brain-derived particles was higher than in the comparison groups.
Peptide
MOTS-c
Outcome
IncreaseNDE MOTS-c in OSA with MCI vs OSA without MCI and controls
Study
n: not reported in source
Comparator
OSA without MCI and control groups
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
The mean CD63-normalized NDE levels of humanin, MOTS-c, and NRGN in the OSA + MCI group were higher than those in the OSA-MCI and control groups.
2 context sentences(design, population, supporting numbers)
Summary · context
Analyses were conducted in 268 study participants with complete polysomnography data, cognitive tests, and important clinical data available.
Summary · context
NDEs were isolated immunochemically for enzyme-linked immunosorbent assay quantification of mitochondrial proteins, i.e., humanin and mitochondrial open reading frame of the 12S rRNA-c (MOTS-c), and synaptic protein, i.e., neurogranin (NRGN).
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3870487101
06HumanEndogenous levelObservational studyOther
In adults with mild cognitive impairment without sleep apnea, neuron-derived exosome MOTS‑c levels were lower than in controls.
In plain wordsIn people with mild cognitive impairment but no sleep apnea, the body's own MOTS‑c in brain-derived particles was lower than in controls.
Peptide
MOTS-c
Outcome
DecreaseNDE MOTS-c in MCI without OSA
Study
n: not reported in source
Comparator
Controls
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
The NDE levels of humanin, MOTS-c, and NRGN in the MCI group were lower than those in controls.
2 context sentences(design, population, supporting numbers)
Summary · context
Analyses were conducted in 268 study participants with complete polysomnography data, cognitive tests, and important clinical data available.
Summary · context
NDEs were isolated immunochemically for enzyme-linked immunosorbent assay quantification of mitochondrial proteins, i.e., humanin and mitochondrial open reading frame of the 12S rRNA-c (MOTS-c), and synaptic protein, i.e., neurogranin (NRGN).
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3870487102
07HumanEndogenous levelObservational studyOther
In adults with obstructive sleep apnea, higher neuron-derived exosome MOTS‑c levels were linked to higher odds of cognitive impairment.
In plain wordsIn people with sleep apnea, higher levels of the body's own MOTS‑c in brain-derived particles were linked to cognitive impairment.
Peptide
MOTS-c
Outcome
IncreaseOdds of cognitive impairment per NDE MOTS-c in OSA
Study
n: not reported in source
Outcome group
Cognition and memory · Nervous system and cognition
Measurements
OR
5.453 ratio
OSA cognitive impairment
Source sentences
Summary
The odds of cognitive impairment in patients with OSA were higher with higher NDE levels of humanin, MOTS-c, and NRGN (odds ratio (OR): 2.100, 95 % confidence interval (CI): 1.646-2.679, P < 0.001; OR: 5.453, 95 % CI: 3.112-9.556, P < 0.001; OR: 3.115, 95 % CI: 2.163-4.484, P < 0.001).
2 context sentences(design, population, supporting numbers)
Summary · context
Analyses were conducted in 268 study participants with complete polysomnography data, cognitive tests, and important clinical data available.
Summary · context
NDEs were isolated immunochemically for enzyme-linked immunosorbent assay quantification of mitochondrial proteins, i.e., humanin and mitochondrial open reading frame of the 12S rRNA-c (MOTS-c), and synaptic protein, i.e., neurogranin (NRGN).
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3870487103
08HumanEndogenous levelObservational studyOther
Impaired cognitive performance was associated with higher neuron-derived exosome MOTS‑c levels.
In plain wordsWorse thinking test results were linked to higher levels of the body's own MOTS‑c in brain-derived particles.
Peptide
MOTS-c
Outcome
IncreaseCognitive performance association with NDE MOTS-c
Study
n: not reported in source
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
The impaired cognitive performance was associated with higher NDE levels of humanin (β: 0.505, SE: 0.048, P < 0.001), MOTS-c (β: 0.580, SE: 0.001, P < 0.001), and NRGN (β: 0.585, SE: 0.553, P < 0.001).
2 context sentences(design, population, supporting numbers)
Summary · context
Analyses were conducted in 268 study participants with complete polysomnography data, cognitive tests, and important clinical data available.
Summary · context
NDEs were isolated immunochemically for enzyme-linked immunosorbent assay quantification of mitochondrial proteins, i.e., humanin and mitochondrial open reading frame of the 12S rRNA-c (MOTS-c), and synaptic protein, i.e., neurogranin (NRGN).
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3870487104
09HumanEndogenous levelObservational studyOther
Neuron-derived exosome MOTS‑c levels, with humanin and neurogranin, mediated the relationship between sleep parameters and MoCA scores.
In plain wordsThe body's own MOTS‑c in brain-derived particles, with two other markers, helped explain the link between low oxygen during sleep and cognition scores.
Peptide
MOTS-c
Outcome
Not applicableMediation of sleep parameters and MoCA by NDE MOTS-c
Study
n: not reported in source
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
The relationship between sleep parameters (mean SaO₂ and T90) and MoCA scores was mediated by the NDE levels of humanin, MOTS-c, and NRGN with the proportion of mediation varying from 35.33 % to 149.07 %.
2 context sentences(design, population, supporting numbers)
Summary · context
Analyses were conducted in 268 study participants with complete polysomnography data, cognitive tests, and important clinical data available.
Summary · context
NDEs were isolated immunochemically for enzyme-linked immunosorbent assay quantification of mitochondrial proteins, i.e., humanin and mitochondrial open reading frame of the 12S rRNA-c (MOTS-c), and synaptic protein, i.e., neurogranin (NRGN).
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3870487105
10HumanEndogenous levelObservational studyOther
Neuron-derived exosome MOTS‑c predicted mild cognitive impairment in OSA patients without dementia with an area under the curve of 0.873.
In plain wordsThe body's own MOTS‑c in brain-derived particles was a fairly good marker of mild cognitive impairment in sleep apnea.
Peptide
MOTS-c
Outcome
Not applicableNDE MOTS-c AUC for MCI in OSA
Study
n: not reported in source
Outcome group
Cognition and memory · Nervous system and cognition
Measurements
AUC
0.873 NA
MCI in OSA
Source sentences
Summary
Receiver operating characteristic curve revealed an area under the curve of 0.905 for humanin, 0.873 for MOTS-c, and 0.934 for NRGN to predict MCI in OSA patients without dementia.
2 context sentences(design, population, supporting numbers)
Summary · context
Analyses were conducted in 268 study participants with complete polysomnography data, cognitive tests, and important clinical data available.
Summary · context
NDEs were isolated immunochemically for enzyme-linked immunosorbent assay quantification of mitochondrial proteins, i.e., humanin and mitochondrial open reading frame of the 12S rRNA-c (MOTS-c), and synaptic protein, i.e., neurogranin (NRGN).
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3870487106
11HumanEndogenous levelObservational studyOther
In adults with OSA and mild cognitive impairment, humanin in neuron-derived exosomes was higher than in OSA without MCI and in controls.
In plain wordsIn adults with sleep apnea and mild cognitive impairment, the body's own humanin in brain-cell exosomes was higher than in comparison groups.
Peptide
Humanin
Outcome
IncreaseNeuron-derived exosome humanin, OSA+MCI versus OSA-MCI and controls
Study
n: not reported in source
Comparator
OSA-MCI and control groups
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
The mean CD63-normalized NDE levels of humanin, MOTS-c, and NRGN in the OSA + MCI group were higher than those in the OSA-MCI and control groups.
2 context sentences(design, population, supporting numbers)
Summary · context
Analyses were conducted in 268 study participants with complete polysomnography data, cognitive tests, and important clinical data available.
Summary · context
NDEs were isolated immunochemically for enzyme-linked immunosorbent assay quantification of mitochondrial proteins, i.e., humanin and mitochondrial open reading frame of the 12S rRNA-c (MOTS-c), and synaptic protein, i.e., neurogranin (NRGN).
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3870487108
12HumanEndogenous levelObservational studyOther
In adults with MCI without OSA, humanin in neuron-derived exosomes was lower than in controls.
In plain wordsIn adults with mild cognitive impairment but no sleep apnea, the body's own humanin in brain-cell exosomes was lower than in controls.
Peptide
Humanin
Outcome
DecreaseNeuron-derived exosome humanin, MCI without OSA versus controls
Study
n: not reported in source
Comparator
Controls
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
The NDE levels of humanin, MOTS-c, and NRGN in the MCI group were lower than those in controls.
2 context sentences(design, population, supporting numbers)
Summary · context
Analyses were conducted in 268 study participants with complete polysomnography data, cognitive tests, and important clinical data available.
Summary · context
NDEs were isolated immunochemically for enzyme-linked immunosorbent assay quantification of mitochondrial proteins, i.e., humanin and mitochondrial open reading frame of the 12S rRNA-c (MOTS-c), and synaptic protein, i.e., neurogranin (NRGN).
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3870487109
13HumanEndogenous levelObservational studyOther
In adults with OSA, higher neuron-derived exosome humanin was linked to higher odds of cognitive impairment.
In plain wordsIn adults with sleep apnea, higher natural humanin in brain-cell exosomes was linked to higher odds of cognitive impairment.
Peptide
Humanin
Outcome
IncreaseOdds of cognitive impairment with higher exosome humanin in OSA
Study
n: not reported in source
Outcome group
Endogenous peptide levels · Nervous system and cognition
Measurements
Odds ratio
2.1
humanin
Source sentences
Summary
The odds of cognitive impairment in patients with OSA were higher with higher NDE levels of humanin, MOTS-c, and NRGN (odds ratio (OR): 2.100, 95 % confidence interval (CI): 1.646-2.679, P < 0.001
2 context sentences(design, population, supporting numbers)
Summary · context
Analyses were conducted in 268 study participants with complete polysomnography data, cognitive tests, and important clinical data available.
Summary · context
NDEs were isolated immunochemically for enzyme-linked immunosorbent assay quantification of mitochondrial proteins, i.e., humanin and mitochondrial open reading frame of the 12S rRNA-c (MOTS-c), and synaptic protein, i.e., neurogranin (NRGN).
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3870487110
14HumanEndogenous levelObservational studyOther
Neuron-derived exosome humanin predicted MCI in OSA patients without dementia with an area under the curve of 0.905.
In plain wordsNatural humanin in brain-cell exosomes predicted mild cognitive impairment in sleep apnea patients with an AUC of 0.905.
Peptide
Humanin
Outcome
Not applicableExosome humanin as predictor of MCI in OSA (ROC)
Study
n: not reported in source
Outcome group
Endogenous peptide levels · Nervous system and cognition
Measurements
AUC
0.905
humanin
Source sentences
Summary
Receiver operating characteristic curve revealed an area under the curve of 0.905 for humanin
2 context sentences(design, population, supporting numbers)
Summary · context
Analyses were conducted in 268 study participants with complete polysomnography data, cognitive tests, and important clinical data available.
Summary · context
NDEs were isolated immunochemically for enzyme-linked immunosorbent assay quantification of mitochondrial proteins, i.e., humanin and mitochondrial open reading frame of the 12S rRNA-c (MOTS-c), and synaptic protein, i.e., neurogranin (NRGN).
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3870487113

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Versions 4 to 18Current
28 Oct 2026, 02:02 UTC
The same notice was added 15 times, first on 13 Oct 2026, 21:44 UTC. The status did not change between them.
Study results updated
Version 3
13 Oct 2026, 16:31 UTC
Study data updated · source update from Europe PMC
Version 2
10 Oct 2026, 08:19 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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Journal Article

MeSH terms

Keywords

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