Nasal application of kisspeptin-54 mitigates motor deficits by reducing nigrostriatal dopamine loss in hemiparkinsonian rats.

Sinen O, Sinen AG, Derin N, Aslan MA

Behavioural brain research3 May 2024Cited by 10 (Europe PMC)

PMID38703793DOI10.1016/j.bbr.2024.115035PepBankPUB-38703793

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In 6-OHDA-lesioned rats, chronic nasal KP-54 at 3 nmol/kg significantly protected against 6-OHDA-induced motor deficits.
In plain wordsIn rats with a Parkinson-like lesion, nasal kisspeptin‑54 reduced the movement problems caused by the lesion.
Peptide
Kisspeptin-54 (metastin)
Outcome
DecreaseMotor deficits (open field and catalepsy tests)
Study
ratn: not reported in source
6-OHDA-lesioned hemiparkinsonian Sprague Dawley rats
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
3 nmol/kg · nasal · 7 daysAs given in this study (rat).
Source sentences
Summary
Chronic administration of KP-54 (3nmol/kg, nasally) significantly protected 6-OHDA-induced motor deficits.
2 context sentences(design, population, supporting numbers)
Summary · context
Male adult Sprague Dawley rats underwent stereotaxic injection of 6-OHDA into the right medial forebrain bundle to induce hemiparkinsonism.
Summary · context
Following surgery, rats received chronic central treatments of nasal or intracerebroventricular KP-54 (logarithmically increasing doses) for seven consecutive days.
Report a problemFND-3870379301
02AnimalAnimal study (in vivo)Efficacy outcome
In 6-OHDA-lesioned rats, nasal KP-54 attenuated the loss of nigrostriatal dopaminergic neurons induced by 6-OHDA.
In plain wordsIn rats with a Parkinson-like lesion, nasal kisspeptin‑54 reduced the loss of dopamine-producing neurons.
Peptide
Kisspeptin-54 (metastin)
Outcome
DecreaseLoss of nigrostriatal dopaminergic neurons
Study
ratn: not reported in source
6-OHDA-lesioned hemiparkinsonian Sprague Dawley rats
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
3 nmol/kg · nasal · 7 daysAs given in this study (rat).
Source sentences
Summary
Nasal KP-54 attenuated the loss of nigrostriatal dopaminergic neurons induced by 6-OHDA.
2 context sentences(design, population, supporting numbers)
Summary · context
Male adult Sprague Dawley rats underwent stereotaxic injection of 6-OHDA into the right medial forebrain bundle to induce hemiparkinsonism.
Summary · context
Following surgery, rats received chronic central treatments of nasal or intracerebroventricular KP-54 (logarithmically increasing doses) for seven consecutive days.
Report a problemFND-3870379302
03AnimalAnimal study (in vivo)Activity measurement
In 6-OHDA-lesioned rats, the dose-response curve gave a median effective dose of about 3 nmol/kg for both central routes of KP-54.
In plain wordsIn rats with a Parkinson-like lesion, about 3 nmol/kg of kisspeptin‑54 was the median effective dose by both central routes.
Peptide
Kisspeptin-54 (metastin)
Outcome
Not applicableMedian effective dose of central KP-54 on motor performance
Study
ratn: not reported in source
6-OHDA-lesioned hemiparkinsonian Sprague Dawley rats
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
logarithmically increasing doses · nasal and intracerebroventricular · 7 daysAs given in this study (rat).
Measurements
median effective dose
≈ 3 nmol/kg
nasal and intracerebroventricular KP-54
Source sentences
Summary
The dose-response curve revealed a median effective dose value of ≈3 nmol/kg for both central injections.
2 context sentences(design, population, supporting numbers)
Summary · context
Male adult Sprague Dawley rats underwent stereotaxic injection of 6-OHDA into the right medial forebrain bundle to induce hemiparkinsonism.
Summary · context
Following surgery, rats received chronic central treatments of nasal or intracerebroventricular KP-54 (logarithmically increasing doses) for seven consecutive days.
Report a problemFND-3870379303
04AnimalAnimal study (in vivo)Mechanism
In 6-OHDA-lesioned rats given KP-54, motor performance correlated significantly with nigrostriatal dopamine levels.
In plain wordsIn rats with a Parkinson-like lesion, better movement went with higher dopamine levels in the brain.
Peptide
Kisspeptin-54 (metastin)
Outcome
Not applicableCorrelation of motor performance with striatal dopamine
Study
ratn: not reported in source
6-OHDA-lesioned hemiparkinsonian Sprague Dawley rats
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
3 nmol/kg · nasal · 7 daysAs given in this study (rat).
Source sentences
Summary
Additionally, significant correlations were observed between motor performance and nigrostriatal dopamine levels.
2 context sentences(design, population, supporting numbers)
Summary · context
Male adult Sprague Dawley rats underwent stereotaxic injection of 6-OHDA into the right medial forebrain bundle to induce hemiparkinsonism.
Summary · context
Following surgery, rats received chronic central treatments of nasal or intracerebroventricular KP-54 (logarithmically increasing doses) for seven consecutive days.
Report a problemFND-3870379304

Studies that did not test the peptide alone1

In this study, Kisspeptin-54 (metastin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-54 (metastin).

05AnimalNot a test of Kisspeptin-54 (metastin) aloneAnimal study (in vivo)Mechanism
In 6-OHDA-lesioned rats, immunohistochemistry located the GPR54 receptor within tyrosine hydroxylase-positive nigral cells.
In plain wordsIn rats, the kisspeptin receptor GPR54 was found inside dopamine-producing cells of the substantia nigra.
Peptide
Kisspeptin-54 (metastin)
Outcome
Not applicableGPR54 localization in nigral cells
Study
ratn: not reported in source
6-OHDA-lesioned hemiparkinsonian Sprague Dawley rats
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Immunohistochemical analysis demonstrated the localization of the GPR54 within TH-positive nigral cells.
2 context sentences(design, population, supporting numbers)
Summary · context
Male adult Sprague Dawley rats underwent stereotaxic injection of 6-OHDA into the right medial forebrain bundle to induce hemiparkinsonism.
Summary · context
Following surgery, rats received chronic central treatments of nasal or intracerebroventricular KP-54 (logarithmically increasing doses) for seven consecutive days.
In this study, Kisspeptin-54 (metastin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-54 (metastin).
Report a problemFND-3870379305

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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