Expression features of T-lymphocytes, B-lymphocytes and macrophages in the post-traumatic regenerate of the mandible rats under conditions of filling a bone defect with hydroxyapatite-containing osteotropic material and thymalin injecting the surrounding soft tissues.

Boiko AA, Malanchuk VA, Myroshnychenko MS, Markovska OV, Shapkin AS, Marakushyn DI

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego1 Jan 2024Cited by 1 (Europe PMC)

PMID38642352DOI10.36740/merkur202402105PepBankPUB-38642352

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymalin.

01AnimalNot a test of Thymalin aloneAnimal study (in vivo)Mechanism
In rats, thymalin with Biomin GT increased T-lymphocyte numbers in mandibular regenerate from the 3rd through the 28th day.
In plain wordsIn rats, thymalin with Biomin GT increased T-cell numbers in repaired jaw tissue.
Peptide
Thymalin
Outcome
IncreaseT-lymphocyte number
Study
ratn: not reported in source
Mandibular bone defect
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
by an increase in the number T-lymphocytes on the 3rd day of the experiment and their increase up to the 28th day
1 context sentence(design, population, supporting numbers)
Summary · context
Group 4 included 12 rats with a simulated holey defect in the lower jaw followed by its closure with hydroxyapatite-containing osteotropic material (bone graft "Biomin GT") and injecting the surrounding soft tissues with thymalin.
In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.
Report a problemFND-3864235201
02AnimalNot a test of Thymalin aloneAnimal study (in vivo)Mechanism
In rats, thymalin with Biomin GT increased B-lymphocyte numbers on the 14th day, with further increases through the 28th day.
In plain wordsIn rats, thymalin with Biomin GT increased B-cell numbers in repaired jaw tissue.
Peptide
Thymalin
Outcome
IncreaseB-lymphocyte number
Study
ratn: not reported in source
Mandibular bone defect
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
by increasing the number of B-lymphocytes on the 14th day of the experiment with their further increase up to the 28th day
1 context sentence(design, population, supporting numbers)
Summary · context
Group 4 included 12 rats with a simulated holey defect in the lower jaw followed by its closure with hydroxyapatite-containing osteotropic material (bone graft "Biomin GT") and injecting the surrounding soft tissues with thymalin.
In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.
Report a problemFND-3864235202
03AnimalNot a test of Thymalin aloneAnimal study (in vivo)Mechanism
In rats, thymalin with Biomin GT increased macrophage numbers from the 3rd through the 28th day in mandibular regenerate.
In plain wordsIn rats, thymalin with Biomin GT increased macrophage numbers in repaired jaw tissue.
Peptide
Thymalin
Outcome
IncreaseMacrophage number
Study
ratn: not reported in source
Mandibular bone defect
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
by increasing the number of macrophages on the 3rd day of the experiment and their growth up to the 28th day
1 context sentence(design, population, supporting numbers)
Summary · context
Group 4 included 12 rats with a simulated holey defect in the lower jaw followed by its closure with hydroxyapatite-containing osteotropic material (bone graft "Biomin GT") and injecting the surrounding soft tissues with thymalin.
In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.
Report a problemFND-3864235203
04AnimalNot a test of Thymalin aloneAnimal study (in vivo)Mechanism
In rats, thymalin with Biomin GT decreased M1-macrophage numbers in mandibular regenerate.
In plain wordsIn rats, thymalin with Biomin GT reduced M1-macrophage numbers in repaired jaw tissue.
Peptide
Thymalin
Outcome
DecreaseM1-macrophage number
Study
ratn: not reported in source
Mandibular bone defect
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
fourth, changes in macrophages phenotypes (decrease in the number of M1-macrophages and increase in the number of M2-macrophages).
1 context sentence(design, population, supporting numbers)
Summary · context
Group 4 included 12 rats with a simulated holey defect in the lower jaw followed by its closure with hydroxyapatite-containing osteotropic material (bone graft "Biomin GT") and injecting the surrounding soft tissues with thymalin.
In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.
Report a problemFND-3864235204
05AnimalNot a test of Thymalin aloneAnimal study (in vivo)Mechanism
In rats, thymalin with Biomin GT increased M2-macrophage numbers in mandibular regenerate.
In plain wordsIn rats, thymalin with Biomin GT increased M2-macrophage numbers in repaired jaw tissue.
Peptide
Thymalin
Outcome
IncreaseM2-macrophage number
Study
ratn: not reported in source
Mandibular bone defect
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
fourth, changes in macrophages phenotypes (decrease in the number of M1-macrophages and increase in the number of M2-macrophages).
1 context sentence(design, population, supporting numbers)
Summary · context
Group 4 included 12 rats with a simulated holey defect in the lower jaw followed by its closure with hydroxyapatite-containing osteotropic material (bone graft "Biomin GT") and injecting the surrounding soft tissues with thymalin.
In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.
Report a problemFND-3864235205

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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