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Study · Not a test of the peptide alone · 2024

4 results

Mated-Atom Nanozymes with Efficient Assisted NAD+ Replenishment for Skin Regeneration.

Liu X, Wan Z, Chen K, Yan Y, Li X, Wang Y, Wang M, Zhao R, Pei J, Zhang L, Sun S, Li J and 8 more

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Chen X, Xin Q, Zhang S, Liu S, Wang H, Liu C, Mu X, Zhang XD

Nano letters15 Apr 2024Cited by 9 (Europe PMC)

PMID38619329 (opens in a new tab)DOI10.1021/acs.nanolett.4c00546 (opens in a new tab)PepBankPUB-38619329
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking NAD+ (nicotinamide adenine dinucleotide).

  1. 01LabNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneIn vitro (cells)Mechanism

    In macrophages, NAD-regenerating RhCo nanozymes promoted polarization toward the M2 phenotype.

    In plain wordsIn cells, NAD-regenerating RhCo nanozymes promoted macrophage polarization toward the M2 type.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseM2 polarization
    Study

    n: not reported in source

    Macrophage polarization model
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Thus, RhCo MAN can significantly promote the regeneration of NAD+ and regulate macrophage polarization toward the M2 phenotype through down-regulation of TLR4 expression, which may help to recover skin regeneration.

    In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).

  2. 02LabNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneIn vitro (cells)Mechanism

    In macrophages, NAD-regenerating RhCo nanozymes regulated polarization through reduced TLR4 expression.

    In plain wordsIn cells, NAD-regenerating RhCo nanozymes reduced TLR4 expression during macrophage polarization.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseTLR4 expression
    Study

    n: not reported in source

    Macrophage polarization model
    Outcome group
    Receptor activity and mechanism · Immune and inflammation

    Source sentences

    Summary
    Thus, RhCo MAN can significantly promote the regeneration of NAD+ and regulate macrophage polarization toward the M2 phenotype through down-regulation of TLR4 expression, which may help to recover skin regeneration.

    In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).

  3. 03LabNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneIn vitro (cell-free)Activity measurement

    In cell-free tests, RhCo nanozymes that regenerate NAD had a lower NADH Km than previously reported NOX mimics.

    In plain wordsIn lab tests, NAD-regenerating RhCo nanozymes had a lower NADH Km than previously reported NOX mimics.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseNADH oxidation affinity
    Study

    n: not reported in source

    RhCo mated-atom nanozyme NADH oxidation
    Comparator
    Previously reported NOX mimics
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Measurements

    Km-NADH
    16.11 μM
    RhCo MAN

    Source sentences

    Summary
    Excitingly, RhCo MAN possesses excellent and sustainable NOX-like activity, with Km-NADH (16.11 μM) being lower than that of NOX-mimics reported so far.

    In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).

  4. 04LabNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneIn vitro (cell-free)Mechanism

    In lab tests, RhCo nanozymes promoted NAD regeneration.

    In plain wordsIn lab tests, RhCo nanozymes promoted NAD regeneration.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseNAD regeneration
    Study

    n: not reported in source

    RhCo mated-atom nanozyme NADH oxidation
    Outcome group
    Mitochondrial function · Immune and inflammation

    Source sentences

    Summary
    Thus, RhCo MAN can significantly promote the regeneration of NAD+ and regulate macrophage polarization toward the M2 phenotype through down-regulation of TLR4 expression, which may help to recover skin regeneration.

    In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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