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Study · Animal study (in vivo) · mouse · 2024

13 results

Nicotinamide adenine dinucleotide treatment confers resistance to neonatal ischemia and hypoxia: effects on neurobehavioral phenotypes.

Xu X, Wang X, Zhang L, Jin Y, Li L, Jin M, Li L, Ni H

Neural regeneration research1 Mar 2024Cited by 6 (Europe PMC)

PMID38595293 (opens in a new tab)PMCIDPMC11168517 (opens in a new tab)DOI10.4103/nrr.nrr-d-23-01490 (opens in a new tab)PepBankPUB-38595293
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study13

13 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In neonatal hypoxic-ischemic injury mice, NAD treatment improved body weight.

    In plain wordsIn mice with neonatal hypoxic-ischemic brain injury, NAD improved body weight.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    Direction not reportedBody weight
    Study

    mousen: not reported in source

    Neonatal hypoxic-ischemic brain injury mice
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    5 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    The results showed that nicotinamide adenine dinucleotide treatment improved body weight, brain structure, adenosine triphosphate levels, oxidative damage, neurobehavioral test outcomes, and seizure threshold in experimental mice.
    2 context sentences
    Summary · context
    Here, we investigated the neuroprotective and molecular mechanisms of exogenous nicotinamide adenine dinucleotide, which can protect against hypoxic injury in adulthood, in a mouse model of neonatal hypoxic-ischemic brain injury.
    Summary · context
    In this study, nicotinamide adenine dinucleotide (5 mg/kg) was intraperitoneally administered 30 minutes before surgery and every 24 hours thereafter.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In neonatal hypoxic-ischemic injury mice, NAD treatment improved brain structure.

    In plain wordsIn mice with neonatal hypoxic-ischemic brain injury, NAD improved brain structure.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    Direction not reportedBrain structure
    Study

    mousen: not reported in source

    Neonatal hypoxic-ischemic brain injury mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    5 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    The results showed that nicotinamide adenine dinucleotide treatment improved body weight, brain structure, adenosine triphosphate levels, oxidative damage, neurobehavioral test outcomes, and seizure threshold in experimental mice.
    2 context sentences
    Summary · context
    Here, we investigated the neuroprotective and molecular mechanisms of exogenous nicotinamide adenine dinucleotide, which can protect against hypoxic injury in adulthood, in a mouse model of neonatal hypoxic-ischemic brain injury.
    Summary · context
    In this study, nicotinamide adenine dinucleotide (5 mg/kg) was intraperitoneally administered 30 minutes before surgery and every 24 hours thereafter.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In neonatal hypoxic-ischemic injury mice, NAD treatment improved adenosine triphosphate levels without a stated direction.

    In plain wordsIn mice with neonatal hypoxic-ischemic brain injury, NAD improved ATP levels, but the abstract did not state their direction.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    Direction not reportedATP levels
    Study

    mousen: not reported in source

    Neonatal hypoxic-ischemic brain injury mice
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    5 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    The results showed that nicotinamide adenine dinucleotide treatment improved body weight, brain structure, adenosine triphosphate levels, oxidative damage, neurobehavioral test outcomes, and seizure threshold in experimental mice.
    2 context sentences
    Summary · context
    Here, we investigated the neuroprotective and molecular mechanisms of exogenous nicotinamide adenine dinucleotide, which can protect against hypoxic injury in adulthood, in a mouse model of neonatal hypoxic-ischemic brain injury.
    Summary · context
    In this study, nicotinamide adenine dinucleotide (5 mg/kg) was intraperitoneally administered 30 minutes before surgery and every 24 hours thereafter.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In neonatal hypoxic-ischemic injury mice, NAD treatment improved oxidative damage.

    In plain wordsIn mice with neonatal hypoxic-ischemic brain injury, NAD reduced oxidative damage.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseOxidative damage
    Study

    mousen: not reported in source

    Neonatal hypoxic-ischemic brain injury mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    5 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    The results showed that nicotinamide adenine dinucleotide treatment improved body weight, brain structure, adenosine triphosphate levels, oxidative damage, neurobehavioral test outcomes, and seizure threshold in experimental mice.
    2 context sentences
    Summary · context
    Here, we investigated the neuroprotective and molecular mechanisms of exogenous nicotinamide adenine dinucleotide, which can protect against hypoxic injury in adulthood, in a mouse model of neonatal hypoxic-ischemic brain injury.
    Summary · context
    In this study, nicotinamide adenine dinucleotide (5 mg/kg) was intraperitoneally administered 30 minutes before surgery and every 24 hours thereafter.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In neonatal hypoxic-ischemic injury mice, NAD treatment improved neurobehavioral test outcomes.

    In plain wordsIn mice with neonatal hypoxic-ischemic brain injury, NAD improved neurobehavioral test results.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    Direction not reportedNeurobehavioral test outcomes
    Study

    mousen: not reported in source

    Neonatal hypoxic-ischemic brain injury mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    5 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    The results showed that nicotinamide adenine dinucleotide treatment improved body weight, brain structure, adenosine triphosphate levels, oxidative damage, neurobehavioral test outcomes, and seizure threshold in experimental mice.
    2 context sentences
    Summary · context
    Here, we investigated the neuroprotective and molecular mechanisms of exogenous nicotinamide adenine dinucleotide, which can protect against hypoxic injury in adulthood, in a mouse model of neonatal hypoxic-ischemic brain injury.
    Summary · context
    In this study, nicotinamide adenine dinucleotide (5 mg/kg) was intraperitoneally administered 30 minutes before surgery and every 24 hours thereafter.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In neonatal hypoxic-ischemic injury mice, NAD treatment improved seizure threshold without a stated direction.

    In plain wordsIn mice with neonatal hypoxic-ischemic brain injury, NAD improved seizure threshold, but the abstract did not state its direction.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    Direction not reportedSeizure threshold
    Study

    mousen: not reported in source

    Neonatal hypoxic-ischemic brain injury mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    5 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    The results showed that nicotinamide adenine dinucleotide treatment improved body weight, brain structure, adenosine triphosphate levels, oxidative damage, neurobehavioral test outcomes, and seizure threshold in experimental mice.
    2 context sentences
    Summary · context
    Here, we investigated the neuroprotective and molecular mechanisms of exogenous nicotinamide adenine dinucleotide, which can protect against hypoxic injury in adulthood, in a mouse model of neonatal hypoxic-ischemic brain injury.
    Summary · context
    In this study, nicotinamide adenine dinucleotide (5 mg/kg) was intraperitoneally administered 30 minutes before surgery and every 24 hours thereafter.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In hypoxic-ischemic injury mice, NAD treatment altered numerous proteins in tandem mass tag proteomics.

    In plain wordsIn mice with hypoxic-ischemic brain injury, NAD changed numerous proteins.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    Direction not reportedProteomic changes
    Study

    mousen: not reported in source

    Neonatal hypoxic-ischemic brain injury mice
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    5 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Tandem mass tag proteomics revealed that numerous proteins were altered after nicotinamide adenine dinucleotide treatment in hypoxic-ischemic brain injury mice.
    2 context sentences
    Summary · context
    Here, we investigated the neuroprotective and molecular mechanisms of exogenous nicotinamide adenine dinucleotide, which can protect against hypoxic injury in adulthood, in a mouse model of neonatal hypoxic-ischemic brain injury.
    Summary · context
    In this study, nicotinamide adenine dinucleotide (5 mg/kg) was intraperitoneally administered 30 minutes before surgery and every 24 hours thereafter.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In hypoxic-ischemic injury mice, NAD treatment changed serine or cysteine peptidase inhibitor, clade A, member 3N expression.

    In plain wordsIn mice with hypoxic-ischemic brain injury, NAD changed serine or cysteine peptidase inhibitor, clade A, member 3N expression.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    Direction not reportedSerine or cysteine peptidase inhibitor clade A member 3N expression
    Study

    mousen: not reported in source

    Neonatal hypoxic-ischemic brain injury mice
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    5 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Parallel reaction monitoring and western blotting confirmed changes in the expression levels of proteins including serine (or cysteine) peptidase inhibitor, clade A, member 3N, fibronectin 1, 5'-nucleotidase, cytosolic IA, microtubule associated protein 2, and complexin 2.
    2 context sentences
    Summary · context
    Here, we investigated the neuroprotective and molecular mechanisms of exogenous nicotinamide adenine dinucleotide, which can protect against hypoxic injury in adulthood, in a mouse model of neonatal hypoxic-ischemic brain injury.
    Summary · context
    In this study, nicotinamide adenine dinucleotide (5 mg/kg) was intraperitoneally administered 30 minutes before surgery and every 24 hours thereafter.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In hypoxic-ischemic injury mice, NAD treatment changed fibronectin 1 expression.

    In plain wordsIn mice with hypoxic-ischemic brain injury, NAD changed fibronectin 1 expression.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    Direction not reportedFibronectin 1 expression
    Study

    mousen: not reported in source

    Neonatal hypoxic-ischemic brain injury mice
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    5 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Parallel reaction monitoring and western blotting confirmed changes in the expression levels of proteins including serine (or cysteine) peptidase inhibitor, clade A, member 3N, fibronectin 1, 5'-nucleotidase, cytosolic IA, microtubule associated protein 2, and complexin 2.
    2 context sentences
    Summary · context
    Here, we investigated the neuroprotective and molecular mechanisms of exogenous nicotinamide adenine dinucleotide, which can protect against hypoxic injury in adulthood, in a mouse model of neonatal hypoxic-ischemic brain injury.
    Summary · context
    In this study, nicotinamide adenine dinucleotide (5 mg/kg) was intraperitoneally administered 30 minutes before surgery and every 24 hours thereafter.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In hypoxic-ischemic injury mice, NAD treatment changed cytosolic 5'-nucleotidase IA expression.

    In plain wordsIn mice with hypoxic-ischemic brain injury, NAD changed cytosolic 5'-nucleotidase IA expression.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    Direction not reportedCytosolic 5'-nucleotidase IA expression
    Study

    mousen: not reported in source

    Neonatal hypoxic-ischemic brain injury mice
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    5 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Parallel reaction monitoring and western blotting confirmed changes in the expression levels of proteins including serine (or cysteine) peptidase inhibitor, clade A, member 3N, fibronectin 1, 5'-nucleotidase, cytosolic IA, microtubule associated protein 2, and complexin 2.
    2 context sentences
    Summary · context
    Here, we investigated the neuroprotective and molecular mechanisms of exogenous nicotinamide adenine dinucleotide, which can protect against hypoxic injury in adulthood, in a mouse model of neonatal hypoxic-ischemic brain injury.
    Summary · context
    In this study, nicotinamide adenine dinucleotide (5 mg/kg) was intraperitoneally administered 30 minutes before surgery and every 24 hours thereafter.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In hypoxic-ischemic injury mice, NAD treatment changed microtubule associated protein 2 expression.

    In plain wordsIn mice with hypoxic-ischemic brain injury, NAD changed microtubule associated protein 2 expression.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    Direction not reportedMicrotubule associated protein 2 expression
    Study

    mousen: not reported in source

    Neonatal hypoxic-ischemic brain injury mice
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    5 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Parallel reaction monitoring and western blotting confirmed changes in the expression levels of proteins including serine (or cysteine) peptidase inhibitor, clade A, member 3N, fibronectin 1, 5'-nucleotidase, cytosolic IA, microtubule associated protein 2, and complexin 2.
    2 context sentences
    Summary · context
    Here, we investigated the neuroprotective and molecular mechanisms of exogenous nicotinamide adenine dinucleotide, which can protect against hypoxic injury in adulthood, in a mouse model of neonatal hypoxic-ischemic brain injury.
    Summary · context
    In this study, nicotinamide adenine dinucleotide (5 mg/kg) was intraperitoneally administered 30 minutes before surgery and every 24 hours thereafter.
  12. 12AnimalAnimal study (in vivo)Mechanism

    In hypoxic-ischemic injury mice, NAD treatment changed complexin 2 expression.

    In plain wordsIn mice with hypoxic-ischemic brain injury, NAD changed complexin 2 expression.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    Direction not reportedComplexin 2 expression
    Study

    mousen: not reported in source

    Neonatal hypoxic-ischemic brain injury mice
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    5 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Parallel reaction monitoring and western blotting confirmed changes in the expression levels of proteins including serine (or cysteine) peptidase inhibitor, clade A, member 3N, fibronectin 1, 5'-nucleotidase, cytosolic IA, microtubule associated protein 2, and complexin 2.
    2 context sentences
    Summary · context
    Here, we investigated the neuroprotective and molecular mechanisms of exogenous nicotinamide adenine dinucleotide, which can protect against hypoxic injury in adulthood, in a mouse model of neonatal hypoxic-ischemic brain injury.
    Summary · context
    In this study, nicotinamide adenine dinucleotide (5 mg/kg) was intraperitoneally administered 30 minutes before surgery and every 24 hours thereafter.
  13. 13AnimalAnimal study (in vivo)Mechanism

    In hypoxic-ischemic injury mice, proteomics implicated inflammation-related signaling pathways in NAD-mediated injury amelioration.

    In plain wordsIn mice with hypoxic-ischemic brain injury, protein analyses linked NAD protection to inflammation-related signaling pathways.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    Not applicableInflammation-related signaling
    Study

    mousen: not reported in source

    Neonatal hypoxic-ischemic brain injury mice
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    5 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Proteomics analyses showed that nicotinamide adenine dinucleotide ameliorated hypoxic-ischemic injury through inflammation-related signaling pathways (e.g., nuclear factor-kappa B, mitogen-activated protein kinase, and phosphatidylinositol 3 kinase/protein kinase B).
    2 context sentences
    Summary · context
    Here, we investigated the neuroprotective and molecular mechanisms of exogenous nicotinamide adenine dinucleotide, which can protect against hypoxic injury in adulthood, in a mouse model of neonatal hypoxic-ischemic brain injury.
    Summary · context
    In this study, nicotinamide adenine dinucleotide (5 mg/kg) was intraperitoneally administered 30 minutes before surgery and every 24 hours thereafter.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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