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Study · Animal study (in vivo) · mouse · 2024

3 results

Humanin inhibits lymphatic endothelial cells dysfunction to alleviate myocardial infarction-reperfusion injury via BNIP3-mediated mitophagy.

Chen L, Yang X, Wang K, Guo L, Zou C

Free radical research27 Mar 2024Cited by 4 (Europe PMC)

PMID38535980 (opens in a new tab)DOI10.1080/10715762.2024.2333074 (opens in a new tab)PepBankPUB-38535980
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with myocardial infarction-reperfusion injury, humanin reduced the injury.

    In plain wordsIn mice with heart attack reperfusion injury, humanin reduced the injury.

    Peptide
    Humanin
    Outcome
    DecreaseMyocardial infarction-reperfusion injury
    Study

    mousen: not reported in source

    Myocardial infarction-reperfusion injury model
    Outcome group
    Cardiovascular events · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HN effectively reduces such injury in vivo
    1 context sentence
    Summary · context
    For in vivo experiments, the left coronary arteries of C57/BL6 mice were clamped for 45 min followed by 24 h reperfusion to develop MI-reperfusion injury.
  2. 02LabIn vitro (cells)Efficacy outcome

    In primary lymphatic endothelial cells under hypoxia, humanin inhibited cell dysfunction.

    In plain wordsIn lab-grown lymphatic cells under low oxygen, humanin reduced cell dysfunction.

    Peptide
    Humanin
    Outcome
    DecreaseLymphatic endothelial cell dysfunction
    Study

    n: not reported in source

    Primary lymphatic endothelial cells under hypoxia
    Outcome group
    Lung injury and fibrosis · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    also inhibits dysfunction in lymphatic endothelial cells in vitro.
    2 context sentences
    Summary · context
    In this study, primary lymphatic endothelial cells were selected as the experimental model.
    Summary · context
    Cells were maintained under 1% O2 to induce a hypoxic phenotype.
  3. 03LabIn vitro (cells)Mechanism

    In primary lymphatic endothelial cells under hypoxia, the inhibitory effect of humanin on cell dysfunction was mediated through BNIP3-associated mitophagy.

    In plain wordsIn lab-grown lymphatic cells under low oxygen, humanin's protective effect worked through a process that clears damaged mitochondria.

    Peptide
    Humanin
    Outcome
    Not applicableBNIP3-associated mitophagy as mediator
    Study

    n: not reported in source

    Primary lymphatic endothelial cells under hypoxia
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Importantly, this inhibitory effect is mediated through BNIP3-associated mitophagy.
    2 context sentences
    Summary · context
    In this study, primary lymphatic endothelial cells were selected as the experimental model.
    Summary · context
    Cells were maintained under 1% O2 to induce a hypoxic phenotype.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

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