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Study · Animal study (in vivo) · rat (wistar) · 2024

7 results

Mitochondria-targeting peptide SS-31 attenuates ferroptosis via inhibition of the p38 MAPK signaling pathway in the hippocampus of epileptic rats.

Liu X, Wang FY, Chi S, Liu T, Yang HL, Zhong RJ, Li XY, Gao J

Brain research21 Mar 2024Cited by 15 (Europe PMC)

PMID38521160 (opens in a new tab)DOI10.1016/j.brainres.2024.148882 (opens in a new tab)PepBankPUB-38521160
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with pilocarpine-induced epilepsy, SS‑31 (and the p38 MAPK inhibitor) reduced the severity of epileptic seizures compared with the epilepsy group.

    In plain wordsIn rats with induced epilepsy, SS‑31 reduced the severity of seizures compared with untreated epileptic rats.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseSeverity of epileptic seizures
    Study

    rat (Wistar)n: not reported in source

    Pilocarpine-induced epilepsy
    Comparator
    Epilepsy group (EP)
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    reducing the severity of epileptic seizures
    1 context sentence
    Summary · context
    Collectively, our present study was to decipher whether SS-31 inhibits ferroptosis via the p38 MAPK signaling pathway in the rat epilepsy model induced by pilocarpine (PILO).Adult male Wistar rats were randomly divided into four groups: control group (CON group), epilepsy group (EP group), SS-31 tre…
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats with pilocarpine-induced epilepsy, SS‑31 (and the p38 MAPK inhibitor) reversed the epilepsy-related loss of Gpx4 in the hippocampus.

    In plain wordsIn rats with induced epilepsy, SS‑31 restored levels of an anti-ferroptosis protein (Gpx4) in the brain.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseHippocampal Gpx4 expression
    Study

    rat (Wistar)n: not reported in source

    Pilocarpine-induced epilepsy
    Comparator
    Epilepsy group (EP)
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    reversing the expression of Gpx4, P-p38
    1 context sentence
    Summary · context
    Collectively, our present study was to decipher whether SS-31 inhibits ferroptosis via the p38 MAPK signaling pathway in the rat epilepsy model induced by pilocarpine (PILO).Adult male Wistar rats were randomly divided into four groups: control group (CON group), epilepsy group (EP group), SS-31 tre…
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats with pilocarpine-induced epilepsy, SS‑31 (and the p38 MAPK inhibitor) reversed the epilepsy-related rise of P-p38 in the hippocampus.

    In plain wordsIn rats with induced epilepsy, SS‑31 lowered an activated stress-signal protein (P-p38) in the brain.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseHippocampal phosphorylated p38 MAPK (P-p38)
    Study

    rat (Wistar)n: not reported in source

    Pilocarpine-induced epilepsy
    Comparator
    Epilepsy group (EP)
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    reversing the expression of Gpx4, P-p38
    1 context sentence
    Summary · context
    Collectively, our present study was to decipher whether SS-31 inhibits ferroptosis via the p38 MAPK signaling pathway in the rat epilepsy model induced by pilocarpine (PILO).Adult male Wistar rats were randomly divided into four groups: control group (CON group), epilepsy group (EP group), SS-31 tre…
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats with pilocarpine-induced epilepsy, SS‑31 (and the p38 MAPK inhibitor) decreased iron levels in the hippocampus.

    In plain wordsIn rats with induced epilepsy, SS‑31 lowered iron levels in the brain.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseHippocampal iron level
    Study

    rat (Wistar)n: not reported in source

    Pilocarpine-induced epilepsy
    Comparator
    Epilepsy group (EP)
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    decreasing the levels of iron and MDA, as well as increasing the activity of GSH and Nrf2.
    1 context sentence
    Summary · context
    Collectively, our present study was to decipher whether SS-31 inhibits ferroptosis via the p38 MAPK signaling pathway in the rat epilepsy model induced by pilocarpine (PILO).Adult male Wistar rats were randomly divided into four groups: control group (CON group), epilepsy group (EP group), SS-31 tre…
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats with pilocarpine-induced epilepsy, SS‑31 (and the p38 MAPK inhibitor) decreased MDA levels in the hippocampus.

    In plain wordsIn rats with induced epilepsy, SS‑31 lowered a marker of fat damage (MDA) in the brain.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseHippocampal malondialdehyde (MDA) level
    Study

    rat (Wistar)n: not reported in source

    Pilocarpine-induced epilepsy
    Comparator
    Epilepsy group (EP)
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    decreasing the levels of iron and MDA, as well as increasing the activity of GSH and Nrf2.
    1 context sentence
    Summary · context
    Collectively, our present study was to decipher whether SS-31 inhibits ferroptosis via the p38 MAPK signaling pathway in the rat epilepsy model induced by pilocarpine (PILO).Adult male Wistar rats were randomly divided into four groups: control group (CON group), epilepsy group (EP group), SS-31 tre…
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats with pilocarpine-induced epilepsy, SS‑31 (and the p38 MAPK inhibitor) increased GSH activity in the hippocampus.

    In plain wordsIn rats with induced epilepsy, SS‑31 raised the activity of a protective molecule (GSH) in the brain.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseHippocampal glutathione (GSH) activity
    Study

    rat (Wistar)n: not reported in source

    Pilocarpine-induced epilepsy
    Comparator
    Epilepsy group (EP)
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    increasing the activity of GSH and Nrf2.
    1 context sentence
    Summary · context
    Collectively, our present study was to decipher whether SS-31 inhibits ferroptosis via the p38 MAPK signaling pathway in the rat epilepsy model induced by pilocarpine (PILO).Adult male Wistar rats were randomly divided into four groups: control group (CON group), epilepsy group (EP group), SS-31 tre…
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rats with pilocarpine-induced epilepsy, SS‑31 (and the p38 MAPK inhibitor) increased Nrf2 levels in the hippocampus.

    In plain wordsIn rats with induced epilepsy, SS‑31 raised levels of a protective protein (Nrf2) in the brain.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseHippocampal Nrf2 level
    Study

    rat (Wistar)n: not reported in source

    Pilocarpine-induced epilepsy
    Comparator
    Epilepsy group (EP)
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    increasing the activity of GSH and Nrf2.
    1 context sentence
    Summary · context
    Collectively, our present study was to decipher whether SS-31 inhibits ferroptosis via the p38 MAPK signaling pathway in the rat epilepsy model induced by pilocarpine (PILO).Adult male Wistar rats were randomly divided into four groups: control group (CON group), epilepsy group (EP group), SS-31 tre…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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